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Entry version 94 (07 Oct 2020)
Sequence version 1 (21 Aug 2007)
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Protein
Submitted name:

SIPA1 protein

Gene

SIPA1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-392517, Rap1 signalling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SIPA1 proteinImported
Submitted name:
Signal-induced proliferation-associated 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIPA1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 29

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34627, SIPA1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A6QPH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000013884, Expressed in spleen and 17 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6QPH2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000018435

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6QPH2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini320 – 538Rap-GAPInterPro annotationAdd BLAST219
Domaini686 – 762PDZInterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 107DisorderedSequence analysisAdd BLAST107
Regioni126 – 152DisorderedSequence analysisAdd BLAST27
Regioni829 – 894DisorderedSequence analysisAdd BLAST66
Regioni945 – 981DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi831 – 859PolarSequence analysisAdd BLAST29
Compositional biasi960 – 981PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160644

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002127_1_1_1

KEGG Orthology (KO)

More...
KOi
K08013

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGFLMNE

Database of Orthologous Groups

More...
OrthoDBi
28453at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6QPH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWAGGGVGSP RRGPAPAPTD DLFARKLRQP ARPPLTPHTF EPRPTRGPLV
60 70 80 90 100
RSGSDAGEAR PPTPASPRAR AHSHEEASRP AAPPARFFSD PLALLGLPAE
110 120 130 140 150
EPEPEFPPVP EPRCFAHYDV QSLLFDWSPR PRGPGAQAEA SSGTPAAAQD
160 170 180 190 200
QTASSDLLLE APGFVSELGG EGELGLGGPV SPPVPPSLPN AAVSVLEEPQ
210 220 230 240 250
NRTSAYSLEH ADLGAGYYRK YFYGKEHQNF FGLDEALGPV AVSLRREEKD
260 270 280 290 300
SSGGGTLHSY RIIVRTTQLR TLRGTISEDA LPPGPPRGLS PRKLLEHVAP
310 320 330 340 350
RLSPTCLRLG SASPKVPRTL LTLDEQVLSF QRKVGILYCR AGQGSEEEMY
360 370 380 390 400
NNQEAGPAFM QFLTLLGDVV RLKGFESYRA QLDTKTDSTG THSLYTTYQD
410 420 430 440 450
HEIMFHVSTM LPYTPNNQQQ LLRKRHIGND IVTIVFQEPG SKPFCPTTIR
460 470 480 490 500
SHFQHIFLVV RAEAPCTPHT SYRVAVSRTQ DTPAFGPALP PGGGPFAANA
510 520 530 540 550
DFRALLLAKA LNGEQAAGHA RQFHAMATRT RQQYLQDLAT NEVTTTSLDS
560 570 580 590 600
ASRFGLPSLG GRRRAAPRGP GAELQAAGAL VWGVRAAPGA RGAAGAEAGS
610 620 630 640 650
SDGAEVPCLL GISAEALVLV APRDGRVVFN CSCRDVLAWT FSEQRLDLYY
660 670 680 690 700
GRGEAITLRF DGPPGQAVGE VVARLQLVSR GCETRELALP RDGQGRLGFE
710 720 730 740 750
VDAAGFITHV ERFTFAETTG LRPGARLLRV CGQTVPSLGP EAAAQLLRSA
760 770 780 790 800
PKVCVTVLPP DDSGRPRRSF SELYTLSLQE PSRRGAAEPV QDEAPAEALL
810 820 830 840 850
PDTKQLLQVC LNDSGGPPGP GDLVEERTEF LHSQNPPSPS SSLSDEAPVL
860 870 880 890 900
PNTTPDLLLA TTAKPAAPSE GRETPLTQDG PGSPGGFEDK DEPAPELRAS
910 920 930 940 950
FLPRTLSLRN SISKIMSEAG SETLEDEWQS ISEIASTCNT ILESLSREGQ
960 970 980 990 1000
PILESGDAKG TPKSDAEPEP SSLSEKVSHL ESMLRKLQDD LQKEKADRAA
1010 1020 1030 1040
LEEEVRSLRH NNRRLQAESE SAATRLLLAS KQLGSLATDL A
Length:1,041
Mass (Da):111,699
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1DE79F99951CE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MI55A0A3Q1MI55_BOVIN
Signal-induced proliferation-associ...
SIPA1
1,146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC149322 mRNA Translation: AAI49323.1

NCBI Reference Sequences

More...
RefSeqi
NP_001095365.1, NM_001101895.2
XP_005227087.1, XM_005227030.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000018435; ENSBTAP00000018435; ENSBTAG00000013884

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
508234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:508234

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149322 mRNA Translation: AAI49323.1
RefSeqiNP_001095365.1, NM_001101895.2
XP_005227087.1, XM_005227030.3

3D structure databases

SMRiA6QPH2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018435

Proteomic databases

PRIDEiA6QPH2

Genome annotation databases

EnsembliENSBTAT00000018435; ENSBTAP00000018435; ENSBTAG00000013884
GeneIDi508234
KEGGibta:508234

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6494
VGNCiVGNC:34627, SIPA1

Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00940000160644
HOGENOMiCLU_002127_1_1_1
KOiK08013
OMAiPGFLMNE
OrthoDBi28453at2759
TreeFamiTF318626

Enzyme and pathway databases

ReactomeiR-BTA-392517, Rap1 signalling

Gene expression databases

BgeeiENSBTAG00000013884, Expressed in spleen and 17 other tissues
ExpressionAtlasiA6QPH2, baseline and differential

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6QPH2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6QPH2
Secondary accession number(s): F1MI57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 7, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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