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Entry version 100 (02 Jun 2021)
Sequence version 1 (21 Aug 2007)
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Protein
Submitted name:

ZNF423 protein

Gene

ZNF423

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ZNF423 proteinImported
Submitted name:
Zinc finger protein 423Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF423Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:37273, ZNF423

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000017397, Expressed in testis and 90 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000023130

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 173C2H2-typeInterPro annotationAdd BLAST28
Domaini174 – 201C2H2-typeInterPro annotationAdd BLAST28
Domaini202 – 229C2H2-typeInterPro annotationAdd BLAST28
Domaini230 – 257C2H2-typeInterPro annotationAdd BLAST28
Domaini271 – 299C2H2-typeInterPro annotationAdd BLAST29
Domaini303 – 331C2H2-typeInterPro annotationAdd BLAST29
Domaini488 – 516C2H2-typeInterPro annotationAdd BLAST29
Domaini525 – 548C2H2-typeInterPro annotationAdd BLAST24
Domaini640 – 662C2H2-typeInterPro annotationAdd BLAST23
Domaini670 – 692C2H2-typeInterPro annotationAdd BLAST23
Domaini700 – 724C2H2-typeInterPro annotationAdd BLAST25
Domaini728 – 756C2H2-typeInterPro annotationAdd BLAST29
Domaini758 – 786C2H2-typeInterPro annotationAdd BLAST29
Domaini789 – 816C2H2-typeInterPro annotationAdd BLAST28
Domaini815 – 838C2H2-typeInterPro annotationAdd BLAST24
Domaini894 – 921C2H2-typeInterPro annotationAdd BLAST28
Domaini938 – 965C2H2-typeInterPro annotationAdd BLAST28
Domaini967 – 994C2H2-typeInterPro annotationAdd BLAST28
Domaini1128 – 1156C2H2-typeInterPro annotationAdd BLAST29
Domaini1176 – 1203C2H2-typeInterPro annotationAdd BLAST28
Domaini1206 – 1233C2H2-typeInterPro annotationAdd BLAST28
Domaini1237 – 1265C2H2-typeInterPro annotationAdd BLAST29
Domaini1267 – 1292C2H2-typeInterPro annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 70DisorderedSequence analysisAdd BLAST70
Regioni95 – 125DisorderedSequence analysisAdd BLAST31
Regioni354 – 407DisorderedSequence analysisAdd BLAST54
Regioni598 – 632DisorderedSequence analysisAdd BLAST35
Regioni1144 – 1171DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 60Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi109 – 123Polar residuesSequence analysisAdd BLAST15
Compositional biasi357 – 397Polar residuesSequence analysisAdd BLAST41
Compositional biasi608 – 632Polar residuesSequence analysisAdd BLAST25
Compositional biasi1144 – 1158Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004018_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLPEGNH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331504

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 24 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6QNQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQAKPR SVKVEEGEAS DFSLAWDSSV TASGGLEGEP ECDRKTSRVL
60 70 80 90 100
EDRNSVTSQE ERNEDDEDVE DESIYTCDHC QQDFESLAEL TDHRAHRCPG
110 120 130 140 150
DGDDDPQLSW VASSPSSKDV ASPTQMIGDG CDLGLGEEEG GTGLPYPCQF
160 170 180 190 200
CDKSFIRLSY LKRHEQIHSD KLPFKCTYCS RLFKHKRSRD RHIKLHTGDK
210 220 230 240 250
KYHCHECEAA FSRSDHLKIH LKTHSSSKPF KCTVCKRGFS STSSLQSHMQ
260 270 280 290 300
AHKKNKEHLA KSEKEAKKDD FMCDYCEDTF SQTEELEKHV LTRHPQLSEK
310 320 330 340 350
ADLQCIHCPE VFVDENALLA HIHQAHANQK HKCPMCPEQF SSVEGVYCHL
360 370 380 390 400
DSHRQPDSSN HSVSPDPVLG SVASMSSATP DSSASVERGS TPDSTLKPLR
410 420 430 440 450
GQKKMRDDGQ GWSKVVYSCP YCSKRDFNSL AVLEIHLKTI HADKPQQSHT
460 470 480 490 500
CQICLDSMPT LYNLNEHVRK LHKNHAYPVM QFGSISAFHC NYCPEMFADI
510 520 530 540 550
NSLQEHIRVS HCGPNANPPD GNNAFFCNQC SMGFLTESSL TEHIQQAHCS
560 570 580 590 600
VGSAKLESPV VQPTQSFMEV YSCPYCTNSP IFGSILKLTK HIKENHKNIP
610 620 630 640 650
LAHSKKSKAE QSPVSSDVEV SSPKRQRLSA SANSISNGEY PCNQCDLKFS
660 670 680 690 700
NFESFQTHLK LHLELLLRKQ ACPQCKEDFD SQESLLQHLT VHYMTTSTHY
710 720 730 740 750
VCESCDKQFS SVDDLQKHLL DMHTFVLYHC TLCQEVFDSK VSIQVHLAVK
760 770 780 790 800
HSNEKKMFRC TACNWDFRKE ADLQVHVKHS HLGNPARAHK CIFCGETFST
810 820 830 840 850
EVELQCHITT HSKKYNCKFC SKAFHAIILL EKHLREKHCV FDAAAENGTA
860 870 880 890 900
NGVPPAAAKK AEPADLPGVL LKNPEAPNSH EASEDDVDAS EPMYGCDICG
910 920 930 940 950
AAYTMEVLLQ NHRLRDHNIR PGEDDGSRKK AEFIKGSHKC NVCSRTFFSE
960 970 980 990 1000
NGLREHLQTH RGPAKHYMCP ICGERFPSLL TLTEHKVTHS KSLDTGTCRI
1010 1020 1030 1040 1050
CKMPLQSEEE FIEHCQMHPD LRNSLTGFRC VVCMQTVTST LELKIHGTFH
1060 1070 1080 1090 1100
MQKLAGSSAA SSPNGQGLQK LYKCALCLKE FRSKQDLVKL DVNGLPYGLC
1110 1120 1130 1140 1150
AGCMARSANG QVGGLAPPEP ADRPCAGLRC PECSVKFESA EDLESHMQVD
1160 1170 1180 1190 1200
HRDLTPETSG PRKGAQTSPV PRKKTYQCIK CQMTFENERE IQIHVANHMI
1210 1220 1230 1240 1250
EEGINHECKL CNQMFDSPAK LLCHLIEHSF EGMGGTFKCP VCFTVFVQAN
1260 1270 1280 1290
KLQQHIFAVH GQEDKIYDCS QCPQKFFFQT ELQNHTMSQH AQ
Length:1,292
Mass (Da):145,270
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i685D25271D51F193
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1N776A0A3Q1N776_BOVIN
Zinc finger protein 423
ZNF423
1,167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1N123A0A3Q1N123_BOVIN
Zinc finger protein 423
ZNF423
1,277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC148946 mRNA Translation: AAI48947.1

NCBI Reference Sequences

More...
RefSeqi
NP_001095363.1, NM_001101893.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000023130; ENSBTAP00000023130; ENSBTAG00000017397

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
508025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:508025

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148946 mRNA Translation: AAI48947.1
RefSeqiNP_001095363.1, NM_001101893.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023130

Genome annotation databases

EnsembliENSBTAT00000023130; ENSBTAP00000023130; ENSBTAG00000017397
GeneIDi508025
KEGGibta:508025

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23090
VGNCiVGNC:37273, ZNF423

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158492
HOGENOMiCLU_004018_0_0_1
OMAiCLPEGNH
OrthoDBi1318335at2759
TreeFamiTF331504

Gene expression databases

BgeeiENSBTAG00000017397, Expressed in testis and 90 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 30 hits
SUPFAMiSSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 24 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6QNQ0_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6QNQ0
Secondary accession number(s): F1MZS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 2, 2021
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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