UniProtKB - A6QLU1 (GPDM_BOVIN)
Protein
Glycerol-3-phosphate dehydrogenase, mitochondrial
Gene
GPD2
Organism
Bos taurus (Bovine)
Status
Functioni
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.By similarity
Catalytic activityi
Cofactori
FADBy similarity
Activity regulationi
Calcium-binding enhance the activity of the enzyme.By similarity
: glycerol degradation via glycerol kinase pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (aerobic route).Proteins known to be involved in this subpathway in this organism are:
- Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (aerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 71 – 99 | FADSequence analysisAdd BLAST | 29 | |
Calcium bindingi | 672 – 683 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
GO - Biological processi
- glycerol-3-phosphate metabolic process Source: InterPro
- glycerol catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Calcium, FAD, Flavoprotein, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00674 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3By similarity)Short name: GPD-M Short name: GPDH-M |
Gene namesi | Name:GPD2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:29531, GPD2 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: GO_Central
Other locations
- glycerol-3-phosphate dehydrogenase complex Source: InterPro
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 42 | MitochondrionBy similarityAdd BLAST | 42 | |
ChainiPRO_0000355966 | 43 – 727 | Glycerol-3-phosphate dehydrogenase, mitochondrialAdd BLAST | 685 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 601 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | A6QLU1 |
PRIDEi | A6QLU1 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000009770, Expressed in conceptus and 19 other tissues |
ExpressionAtlasi | A6QLU1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 623 – 658 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 659 – 694 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.Curated
Keywords - Domaini
Repeat, Transit peptidePhylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_3_1_1 |
InParanoidi | A6QLU1 |
OMAi | AHGFSKT |
OrthoDBi | 669193at2759 |
TreeFami | TF300359 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit PF13499, EF-hand_7, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00977, FAD_G3PDH_1, 1 hit PS00978, FAD_G3PDH_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A6QLU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFQKAVKGT ILVGGGALAT VLGLSHFAHY KRKQVNLAFV EAADCISEPV
60 70 80 90 100
NREPPSREAQ ILTLKNTSEF DVLVIGGGAT GSGCALDAVT RGLKTALVER
110 120 130 140 150
DDFSSGTSSR STKLIHGGVR YLQKAIMKLD IEQYRMVKEA LHERANLLEI
160 170 180 190 200
APHLSAPLPI MLPIYKWWQL PYYWVGIKLY DLVAGSNCLK SSYVLSKSRA
210 220 230 240 250
LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYMEVM
260 270 280 290 300
SLLKKTDPQT GKERVSGARC KDVLTGEEFD VRAKCVINAT GPFTDTVRKM
310 320 330 340 350
DDKDTTAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT
360 370 380 390 400
IAGTTDTPTD VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG
410 420 430 440 450
IRPLVTDPKS ADTKSISRNH VVDISESGLI TIAGGKWTTY RSMAEDTINA
460 470 480 490 500
AVKAHNLKAG PSRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLAAT
510 520 530 540 550
YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG IKEYACTAVD
560 570 580 590 600
MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDSKKEE ELETARKFLY
610 620 630 640 650
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR
660 670 680 690 700
VLESIGVQMD ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR
710 720
LAILMKTAEE NLDRRVPIPV DRSCGGL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MTV4 | A0A3Q1MTV4_BOVIN | Glycerol-3-phosphate dehydrogenase | GPD2 | 727 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC148085 mRNA Translation: AAI48086.1 |
RefSeqi | NP_001093766.1, NM_001100296.1 XP_005202471.1, XM_005202414.3 |
Genome annotation databases
Ensembli | ENSBTAT00000012886; ENSBTAP00000012886; ENSBTAG00000009770 ENSBTAT00000067743; ENSBTAP00000064800; ENSBTAG00000009770 |
GeneIDi | 504948 |
KEGGi | bta:504948 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC148085 mRNA Translation: AAI48086.1 |
RefSeqi | NP_001093766.1, NM_001100296.1 XP_005202471.1, XM_005202414.3 |
3D structure databases
SMRi | A6QLU1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000012886 |
Proteomic databases
PaxDbi | A6QLU1 |
PRIDEi | A6QLU1 |
Genome annotation databases
Ensembli | ENSBTAT00000012886; ENSBTAP00000012886; ENSBTAG00000009770 ENSBTAT00000067743; ENSBTAP00000064800; ENSBTAG00000009770 |
GeneIDi | 504948 |
KEGGi | bta:504948 |
Organism-specific databases
CTDi | 2820 |
VGNCi | VGNC:29531, GPD2 |
Phylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_3_1_1 |
InParanoidi | A6QLU1 |
OMAi | AHGFSKT |
OrthoDBi | 669193at2759 |
TreeFami | TF300359 |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00674 |
Gene expression databases
Bgeei | ENSBTAG00000009770, Expressed in conceptus and 19 other tissues |
ExpressionAtlasi | A6QLU1, baseline and differential |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit PF13499, EF-hand_7, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00977, FAD_G3PDH_1, 1 hit PS00978, FAD_G3PDH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPDM_BOVIN | |
Accessioni | A6QLU1Primary (citable) accession number: A6QLU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 16, 2008 |
Last sequence update: | August 21, 2007 | |
Last modified: | April 7, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families