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Protein

Poly(U)-specific endoribonuclease

Gene

ENDOU

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.By similarity

Cofactori

Mn2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(U)-specific endoribonuclease (EC:3.1.-.-)
Alternative name(s):
Protein endoU
Uridylate-specific endoribonuclease
Gene namesi
Name:ENDOU
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000039422119 – 413Poly(U)-specific endoribonucleaseAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 40AlternatePROSITE-ProRule annotation
Disulfide bondi24 ↔ 28AlternatePROSITE-ProRule annotation
Disulfide bondi28 ↔ 58AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 51AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 40AlternatePROSITE-ProRule annotation
Disulfide bondi44 ↔ 50PROSITE-ProRule annotation
Disulfide bondi51 ↔ 58AlternatePROSITE-ProRule annotation
Disulfide bondi92 ↔ 108AlternatePROSITE-ProRule annotation
Disulfide bondi92 ↔ 96AlternatePROSITE-ProRule annotation
Disulfide bondi96 ↔ 126AlternatePROSITE-ProRule annotation
Disulfide bondi106 ↔ 119AlternatePROSITE-ProRule annotation
Disulfide bondi106 ↔ 108AlternatePROSITE-ProRule annotation
Disulfide bondi112 ↔ 118PROSITE-ProRule annotation
Disulfide bondi119 ↔ 126AlternatePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6QLQ8

Expressioni

Gene expression databases

BgeeiENSBTAG00000012275 Expressed in 7 organ(s), highest expression level in colon

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043168

Structurei

3D structure databases

ProteinModelPortaliA6QLQ8
SMRiA6QLQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 63SMB 1PROSITE-ProRule annotationAdd BLAST44
Domaini88 – 130SMB 2PROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the ENDOU family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2849 Eukaryota
ENOG410XX8E LUCA
GeneTreeiENSGT00530000063825
HOGENOMiHOG000247015
HOVERGENiHBG008236
InParanoidiA6QLQ8
KOiK14648
OMAiRCQEFGN
OrthoDBiEOG091G0D8U
TreeFamiTF319848

Family and domain databases

InterProiView protein in InterPro
IPR018998 EndoU
IPR037227 EndoU-like
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF01033 Somatomedin_B, 2 hits
PF09412 XendoU, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00201 SO, 2 hits
SUPFAMiSSF142877 SSF142877, 1 hit
SSF90188 SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRACVPLTVA ILCGLAWAGK RESCASRCNE RFDRDAVCQC DRRCPQHGDC
60 70 80 90 100
CEDYEQLCTA EENPKEPELF LELEEETEGA PASSLYLAPN SCQGRCLEAF
110 120 130 140 150
DKHHSCHCNA RCPEFGNCCE DFESLCGHEG FSHSSDAITK EELQSVSEKI
160 170 180 190 200
YRADTNKARK EDIVLNSQNC ISPSETRDQV DRCPEPLFTY VNEKLFSKPT
210 220 230 240 250
YSAFLNLLNN YQRATGRGEH FTAQELAEQD TFLREIMKTA VMKELYGFLH
260 270 280 290 300
QQNRYSSEQE FVSDLKNMWF GLYSRSKEER DSSGFEHVFS GEVKKGKVTG
310 320 330 340 350
FHNWIRFYMQ EKEGLVDYYS HIYDGPWDSY PDVLAMQFNW DGYYKEVGSA
360 370 380 390 400
FIGSSPEFEF ALYSLCFIAR PGKVCQLSLG GHPLAIQTYT WNKSTYGNGK
410
KYIATAYVVS STH
Length:413
Mass (Da):47,188
Last modified:August 21, 2007 - v1
Checksum:iECBC928F474B51FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148052 mRNA Translation: AAI48053.1
RefSeqiNP_001095560.1, NM_001102090.1
UniGeneiBt.61409

Genome annotation databases

EnsembliENSBTAT00000045807; ENSBTAP00000043168; ENSBTAG00000012275
GeneIDi525399
KEGGibta:525399

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148052 mRNA Translation: AAI48053.1
RefSeqiNP_001095560.1, NM_001102090.1
UniGeneiBt.61409

3D structure databases

ProteinModelPortaliA6QLQ8
SMRiA6QLQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043168

Proteomic databases

PaxDbiA6QLQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000045807; ENSBTAP00000043168; ENSBTAG00000012275
GeneIDi525399
KEGGibta:525399

Organism-specific databases

CTDi8909

Phylogenomic databases

eggNOGiKOG2849 Eukaryota
ENOG410XX8E LUCA
GeneTreeiENSGT00530000063825
HOGENOMiHOG000247015
HOVERGENiHBG008236
InParanoidiA6QLQ8
KOiK14648
OMAiRCQEFGN
OrthoDBiEOG091G0D8U
TreeFamiTF319848

Gene expression databases

BgeeiENSBTAG00000012275 Expressed in 7 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR018998 EndoU
IPR037227 EndoU-like
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF01033 Somatomedin_B, 2 hits
PF09412 XendoU, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00201 SO, 2 hits
SUPFAMiSSF142877 SSF142877, 1 hit
SSF90188 SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiENDOU_BOVIN
AccessioniPrimary (citable) accession number: A6QLQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: August 21, 2007
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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