UniProtKB - A6QHK1 (GSA1_STAAE)
Protein
Glutamate-1-semialdehyde 2,1-aminomutase 1
Gene
hemL1
Organism
Staphylococcus aureus (strain Newman)
Status
Functioni
Catalytic activityi
- EC:5.4.3.8UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotation
: protoporphyrin-IX biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Glutamyl-tRNA reductase (hemA)
- Glutamate-1-semialdehyde 2,1-aminomutase 2 (hemL2), Glutamate-1-semialdehyde 2,1-aminomutase 1 (hemL1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.
GO - Molecular functioni
- glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-UniRule
- pyridoxal phosphate binding Source: InterPro
- transaminase activity Source: InterPro
GO - Biological processi
- protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Porphyrin biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00317 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation (EC:5.4.3.8UniRule annotation)Short name: GSA 1UniRule annotation Alternative name(s): Glutamate-1-semialdehyde aminotransferase 1UniRule annotation Short name: GSA-AT 1UniRule annotation |
Gene namesi | Name:hemL1UniRule annotation Ordered Locus Names:NWMN_1561 |
Organismi | Staphylococcus aureus (strain Newman) |
Taxonomic identifieri | 426430 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000382377 | 1 – 428 | Glutamate-1-semialdehyde 2,1-aminomutase 1Add BLAST | 428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 267 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_016922_1_5_9 |
OMAi | WGPLIFG |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_00375, HemL_aminotrans_3, 1 hit |
InterProi | View protein in InterPro IPR004639, 4pyrrol_synth_GluAld_NH2Trfase IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR00713, hemL, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A6QHK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRYTKSEEAM KVAETLMPGG VNSPVRAFKS VDTPAIFMDH GKGSKIYDID
60 70 80 90 100
GNEYIDYVLS WGPLILGHRD PQVISHLHEA IDKGTSFGAS TLLENKLAQL
110 120 130 140 150
VIDRVPSIEK VRMVSSGTEA TLDTLRLARG YTGRNKIVKF EGCYHGHSDS
160 170 180 190 200
LLIKAGSGVA TLGLPDSPGV PEGIAKNTIT VPYNDLDALK IAFEKFGNDI
210 220 230 240 250
AGVIVEPVAG NMGVVPPIEG FLQGLRDITT EYGALLIFDE VMTGFRVGYH
260 270 280 290 300
CAQGYFGVTP DLTCLGKVIG GGLPVGAFGG KKEIMDHIAP LGNIYQAGTL
310 320 330 340 350
SGNPLAMTSG YETLSQLTPE TYEYFNMLGD ILEDGLKRVF AKHNVPITVN
360 370 380 390 400
RAGSMIGYFL NEGPVTNFEQ ANKSDLKLFA EMYREMAKEG VFLPPSQFEG
410 420
TFLSTAHTKE DIEKTIQAFD TALSRIVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP009351 Genomic DNA Translation: BAF67833.1 |
RefSeqi | WP_001270868.1, NZ_CP023390.1 |
Genome annotation databases
EnsemblBacteriai | BAF67833; BAF67833; NWMN_1561 |
GeneIDi | 45574878 |
KEGGi | sae:NWMN_1561 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP009351 Genomic DNA Translation: BAF67833.1 |
RefSeqi | WP_001270868.1, NZ_CP023390.1 |
3D structure databases
SMRi | A6QHK1 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | BAF67833; BAF67833; NWMN_1561 |
GeneIDi | 45574878 |
KEGGi | sae:NWMN_1561 |
Phylogenomic databases
HOGENOMi | CLU_016922_1_5_9 |
OMAi | WGPLIFG |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00317 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_00375, HemL_aminotrans_3, 1 hit |
InterProi | View protein in InterPro IPR004639, 4pyrrol_synth_GluAld_NH2Trfase IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR00713, hemL, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GSA1_STAAE | |
Accessioni | A6QHK1Primary (citable) accession number: A6QHK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | August 21, 2007 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families