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Protein

WD repeat-containing protein 76

Gene

Wdr76

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.1 Publication

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • enzyme binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 76
Gene namesi
Name:Wdr76
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926186 Wdr76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003510921 – 622WD repeat-containing protein 76Add BLAST622

Proteomic databases

MaxQBiA6PWY4
PaxDbiA6PWY4
PeptideAtlasiA6PWY4
PRIDEiA6PWY4

PTM databases

iPTMnetiA6PWY4
PhosphoSitePlusiA6PWY4

Expressioni

Gene expression databases

BgeeiENSMUSG00000027242 Expressed in 145 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiA6PWY4 baseline and differential
GenevisibleiA6PWY4 MM

Interactioni

Subunit structurei

Interacts with CUL4A and/or CUL4B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232333, 1 interactor
DIPiDIP-59892N
IntActiA6PWY4, 2 interactors
STRINGi10090.ENSMUSP00000028676

Structurei

3D structure databases

ProteinModelPortaliA6PWY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati310 – 351WD 1Add BLAST42
Repeati356 – 398WD 2Add BLAST43
Repeati400 – 438WD 3Add BLAST39
Repeati443 – 482WD 4Add BLAST40
Repeati490 – 530WD 5Add BLAST41
Repeati540 – 584WD 6Add BLAST45
Repeati587 – 622WD 7Add BLAST36

Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4328 Eukaryota
ENOG410XRID LUCA
GeneTreeiENSGT00510000048144
HOGENOMiHOG000081507
HOVERGENiHBG079574
InParanoidiA6PWY4
OMAiILKPQWQ
OrthoDBiEOG091G07AQ
TreeFamiTF314788

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033052 Cmr1/WDR76
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14773:SF0 PTHR14773:SF0, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6PWY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSKAESEE KAGSKQCPLV QVNEYKENEH IAYTSLRPIQ ITTLRKTAKV
60 70 80 90 100
YLYPFSLSNS KLGLLKLSKS PVVNNSSKSV VHKKKDRKKT RRKVLTSKMK
110 120 130 140 150
ALSSKADSLL LKSSVDAYTE STRLGPKRTS DSATLSVDAE SSDEDSAPGL
160 170 180 190 200
DDFSGLSPYE RKRLRNIREN ANFFASLQLA ESAARLRGMI KKRESPESKR
210 220 230 240 250
KRPKKKENEI GCRRSMRLLK VDPLGVSLPA SPTQPTLVEE EENPLLPPGP
260 270 280 290 300
LEMIPENQDD SSELLKASLK TWAEMSQTSN EKTKKGLSSI KSYKANLSGM
310 320 330 340 350
VISEATVRKV TKGAISSVAL HPSEVRTLVA AGAKSGQIGL WDLTQQSEDA
360 370 380 390 400
MYVFYAHSRY VSCLSFSPTN PAHLLSLSYD GTLRCGDFSS AVFEEVYRNE
410 420 430 440 450
GNSPSSFDFL NDSSSLLVGH WDGHLSLVDR RTPGTSYEKF FNSSLEKIRT
460 470 480 490 500
VHVHPLSRQY FVTAGLRDVH VYDARFLKSR GSQPLISLTE HSKSIASAYF
510 520 530 540 550
SPVTGNRVVT TCADCKLRVF DSSSISSQLP LLSTIRHNTV TGRWLTRFQA
560 570 580 590 600
VWDPKQEDCF IVGSMDHPRR VEVFHESGKN VHSLWGECLV SVCSLSAVHP
610 620
TRYILAGGNS SGKLHVFMHQ ET
Note: No experimental confirmation available.
Length:622
Mass (Da):69,007
Last modified:August 21, 2007 - v1
Checksum:iC6F28ED51BAC60AD
GO
Isoform 2 (identifier: A6PWY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):57,960
Checksum:i1C5A98B1597F3A36
GO
Isoform 3 (identifier: A6PWY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-181: E → ETLVSLLVGVACCPSLN
     397-402: YRNEGN → GSDQEA
     403-622: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):45,787
Checksum:i910D88B0C5E2E74A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YK23Z4YK23_MOUSE
WD repeat-containing protein 76
Wdr76
320Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335S → Y in BAB31961 (PubMed:16141072).Curated1
Sequence conflicti535I → V in AAI17823 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0354631 – 98Missing in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_035464181E → ETLVSLLVGVACCPSLN in isoform 3. 1 Publication1
Alternative sequenceiVSP_035465397 – 402YRNEGN → GSDQEA in isoform 3. 1 Publication6
Alternative sequenceiVSP_035466403 – 622Missing in isoform 3. 1 PublicationAdd BLAST220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020004 mRNA Translation: BAB31961.2
AL928678 Genomic DNA No translation available.
BC094676 mRNA Translation: AAH94676.1
BC117822 mRNA Translation: AAI17823.1
CCDSiCCDS38218.1 [A6PWY4-2]
RefSeqiNP_001277915.1, NM_001290986.1 [A6PWY4-2]
NP_001277916.1, NM_001290987.1
NP_084510.2, NM_030234.2 [A6PWY4-2]
XP_006499556.1, XM_006499493.3 [A6PWY4-1]
UniGeneiMm.293284

Genome annotation databases

EnsembliENSMUST00000028676; ENSMUSP00000028676; ENSMUSG00000027242 [A6PWY4-2]
ENSMUST00000110602; ENSMUSP00000106232; ENSMUSG00000027242 [A6PWY4-2]
ENSMUST00000110603; ENSMUSP00000106234; ENSMUSG00000027242 [A6PWY4-1]
GeneIDi241627
KEGGimmu:241627
UCSCiuc008lzi.1 mouse [A6PWY4-2]
uc008lzj.1 mouse [A6PWY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020004 mRNA Translation: BAB31961.2
AL928678 Genomic DNA No translation available.
BC094676 mRNA Translation: AAH94676.1
BC117822 mRNA Translation: AAI17823.1
CCDSiCCDS38218.1 [A6PWY4-2]
RefSeqiNP_001277915.1, NM_001290986.1 [A6PWY4-2]
NP_001277916.1, NM_001290987.1
NP_084510.2, NM_030234.2 [A6PWY4-2]
XP_006499556.1, XM_006499493.3 [A6PWY4-1]
UniGeneiMm.293284

3D structure databases

ProteinModelPortaliA6PWY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232333, 1 interactor
DIPiDIP-59892N
IntActiA6PWY4, 2 interactors
STRINGi10090.ENSMUSP00000028676

PTM databases

iPTMnetiA6PWY4
PhosphoSitePlusiA6PWY4

Proteomic databases

MaxQBiA6PWY4
PaxDbiA6PWY4
PeptideAtlasiA6PWY4
PRIDEiA6PWY4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028676; ENSMUSP00000028676; ENSMUSG00000027242 [A6PWY4-2]
ENSMUST00000110602; ENSMUSP00000106232; ENSMUSG00000027242 [A6PWY4-2]
ENSMUST00000110603; ENSMUSP00000106234; ENSMUSG00000027242 [A6PWY4-1]
GeneIDi241627
KEGGimmu:241627
UCSCiuc008lzi.1 mouse [A6PWY4-2]
uc008lzj.1 mouse [A6PWY4-1]

Organism-specific databases

CTDi79968
MGIiMGI:1926186 Wdr76

Phylogenomic databases

eggNOGiKOG4328 Eukaryota
ENOG410XRID LUCA
GeneTreeiENSGT00510000048144
HOGENOMiHOG000081507
HOVERGENiHBG079574
InParanoidiA6PWY4
OMAiILKPQWQ
OrthoDBiEOG091G07AQ
TreeFamiTF314788

Miscellaneous databases

PROiPR:A6PWY4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027242 Expressed in 145 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiA6PWY4 baseline and differential
GenevisibleiA6PWY4 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033052 Cmr1/WDR76
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14773:SF0 PTHR14773:SF0, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR76_MOUSE
AccessioniPrimary (citable) accession number: A6PWY4
Secondary accession number(s): A2ASQ8
, A4FUV0, Q504Z3, Q9CTV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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