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Protein
Submitted name:

Cysteine-rich with EGF-like domain protein 2

Gene

CRELD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine-rich with EGF-like domain protein 2Imported
Gene namesi
Name:CRELD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184164.14
HGNCiHGNC:28150 CRELD2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184164

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500270094425 – 229Sequence analysisAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi168 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiA6PWM2
PeptideAtlasiA6PWM2
PRIDEiA6PWM2

Expressioni

Gene expression databases

BgeeiENSG00000184164 Expressed in 219 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiA6PWM2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA6PWM2
SMRiA6PWM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 178EGF-likeInterPro annotationAdd BLAST43

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344

Family and domain databases

CDDicd00064 FU, 1 hit
InterProiView protein in InterPro
IPR021852 DUF3456
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS01248 EGF_LAM_1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6PWM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPRRAALG LLPLLLLLPP APEAAKKPTP CHRCRGLVDK FNQGMVDTAK
60 70 80 90 100
KNFGGGNTAW EEKTLSKYES SEIRLLEILE GLCESSDFEC NQMLEAQEEH
110 120 130 140 150
LEAWWLQLKS EYPDLFEWFC VKTLKVCCSP GTYGPDCLAC QGGSQRPCSG
160 170 180 190 200
NGHCSGDGSR QGDGSCRCHM GYQGPLCTDC MDGYFSSLRN ETHSICTACD
210 220
ESCKTCSGLT NRDCGECEVG WVLDEGACV
Length:229
Mass (Da):25,129
Last modified:August 21, 2007 - v1
Checksum:iD1DE55F1E95286C1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6UXH1CREL2_HUMAN
Cysteine-rich with EGF-like domain ...
CRELD2 UNQ185/PRO211
353Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei229Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671710 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000450207; ENSP00000387769; ENSG00000184164
UCSCiuc062fil.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671710 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA6PWM2
SMRiA6PWM2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA6PWM2
PeptideAtlasiA6PWM2
PRIDEiA6PWM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450207; ENSP00000387769; ENSG00000184164
UCSCiuc062fil.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000184164.14
HGNCiHGNC:28150 CRELD2
OpenTargetsiENSG00000184164
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344

Miscellaneous databases

ChiTaRSiCRELD2 human

Gene expression databases

BgeeiENSG00000184164 Expressed in 219 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiA6PWM2 baseline and differential

Family and domain databases

CDDicd00064 FU, 1 hit
InterProiView protein in InterPro
IPR021852 DUF3456
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS01248 EGF_LAM_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA6PWM2_HUMAN
AccessioniPrimary (citable) accession number: A6PWM2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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