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Entry version 79 (13 Feb 2019)
Sequence version 1 (21 Aug 2007)
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Protein

Protein FAM177B

Gene

FAM177B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM177B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM177B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197520.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34395 FAM177B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6PVY3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197520

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387394

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM177B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003259151 – 158Protein FAM177BAdd BLAST158

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6PVY3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6PVY3

PRoteomics IDEntifications database

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PRIDEi
A6PVY3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1727
1728 [A6PVY3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6PVY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6PVY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197520 Expressed in 83 organ(s), highest expression level in small intestine Peyer's patch

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6PVY3 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063059

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A6PVY3, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6PVY3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 49Poly-Glu10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM177 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IXRC Eukaryota
ENOG410YRX6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016736

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112452

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6PVY3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSTCEFL

Database of Orthologous Groups

More...
OrthoDBi
1572938at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6PVY3

TreeFam database of animal gene trees

More...
TreeFami
TF326916

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028260 FAM177

The PANTHER Classification System

More...
PANTHERi
PTHR31206 PTHR31206, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14774 FAM177, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6PVY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIDGFQQLD LEKSVPSKKT TPKRIIHFVD GDIMEEYSTE EEEEEEKEEQ
60 70 80 90 100
STNSTLDPSK LSWGPYLRFW AGRIASTSFS TCEFLGGRFA VFFGLTQPKY
110 120 130 140 150
QYVLNEFYRI QNKKSDNKSE RRGSKAQAAE VPNEKCHLEA GVQEYGTIQQ

DVTEAIPQ
Length:158
Mass (Da):18,145
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89E4532266015349
GO
Isoform 2 (identifier: A6PVY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-120: TCEFLGGRFA...QNKKSDNKSE → MLSLQATLLL...FLMWVLVTLD
     121-158: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,796
Checksum:i713555BAF230910D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVY2A6PVY2_HUMAN
Protein FAM177B
FAM177B
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVY1A6PVY1_HUMAN
Protein FAM177B
FAM177B
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0399533I → S. Corresponds to variant dbSNP:rs2378607Ensembl.1
Natural variantiVAR_054090143Q → R. Corresponds to variant dbSNP:rs6683071Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03247681 – 120TCEFL…DNKSE → MLSLQATLLLKAEKEGLKQL LRSLSGCMEEFLMWVLVTLD in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_032477121 – 158Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK125494 mRNA Translation: BAC86182.1
AL392172 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1535.2 [A6PVY3-1]

NCBI Reference Sequences

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RefSeqi
NP_001311009.1, NM_001324080.1 [A6PVY3-1]
NP_997351.2, NM_207468.2 [A6PVY3-1]
XP_016856768.1, XM_017001279.1 [A6PVY3-1]
XP_016856769.1, XM_017001280.1 [A6PVY3-1]
XP_016856770.1, XM_017001281.1 [A6PVY3-1]
XP_016856771.1, XM_017001282.1 [A6PVY3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.697608

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360827; ENSP00000354070; ENSG00000197520 [A6PVY3-1]
ENST00000391880; ENSP00000375752; ENSG00000197520 [A6PVY3-2]
ENST00000445590; ENSP00000414451; ENSG00000197520 [A6PVY3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
400823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:400823

UCSC genome browser

More...
UCSCi
uc009xeb.4 human [A6PVY3-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125494 mRNA Translation: BAC86182.1
AL392172 Genomic DNA No translation available.
CCDSiCCDS1535.2 [A6PVY3-1]
RefSeqiNP_001311009.1, NM_001324080.1 [A6PVY3-1]
NP_997351.2, NM_207468.2 [A6PVY3-1]
XP_016856768.1, XM_017001279.1 [A6PVY3-1]
XP_016856769.1, XM_017001280.1 [A6PVY3-1]
XP_016856770.1, XM_017001281.1 [A6PVY3-1]
XP_016856771.1, XM_017001282.1 [A6PVY3-1]
UniGeneiHs.697608

3D structure databases

ProteinModelPortaliA6PVY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6PVY3, 2 interactors

PTM databases

iPTMnetiA6PVY3
PhosphoSitePlusiA6PVY3

Polymorphism and mutation databases

BioMutaiFAM177B

Proteomic databases

jPOSTiA6PVY3
PaxDbiA6PVY3
PRIDEiA6PVY3
ProteomicsDBi1727
1728 [A6PVY3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360827; ENSP00000354070; ENSG00000197520 [A6PVY3-1]
ENST00000391880; ENSP00000375752; ENSG00000197520 [A6PVY3-2]
ENST00000445590; ENSP00000414451; ENSG00000197520 [A6PVY3-1]
GeneIDi400823
KEGGihsa:400823
UCSCiuc009xeb.4 human [A6PVY3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
400823
EuPathDBiHostDB:ENSG00000197520.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM177B
HGNCiHGNC:34395 FAM177B
HPAiHPA063059
neXtProtiNX_A6PVY3
OpenTargetsiENSG00000197520
PharmGKBiPA162387394

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXRC Eukaryota
ENOG410YRX6 LUCA
GeneTreeiENSGT00390000016736
HOGENOMiHOG000112452
InParanoidiA6PVY3
OMAiFSTCEFL
OrthoDBi1572938at2759
PhylomeDBiA6PVY3
TreeFamiTF326916

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM177B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
400823

Protein Ontology

More...
PROi
PR:A6PVY3

Gene expression databases

BgeeiENSG00000197520 Expressed in 83 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiA6PVY3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028260 FAM177
PANTHERiPTHR31206 PTHR31206, 1 hit
PfamiView protein in Pfam
PF14774 FAM177, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF177B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6PVY3
Secondary accession number(s): Q6ZUN8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: February 13, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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