Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 100 (17 Jun 2020)
Sequence version 1 (21 Aug 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Ryanodine receptor 1b

Gene

ryr1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ryr1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070705-417 ryr1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4343 – 4366HelicalSequence analysisAdd BLAST24
Transmembranei4579 – 4599HelicalSequence analysisAdd BLAST21
Transmembranei4680 – 4702HelicalSequence analysisAdd BLAST23
Transmembranei4828 – 4856HelicalSequence analysisAdd BLAST29
Transmembranei4876 – 4898HelicalSequence analysisAdd BLAST23
Transmembranei4957 – 4980HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A6P4B8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 152MIRInterPro annotationAdd BLAST56
Domaini159 – 204MIRInterPro annotationAdd BLAST46
Domaini212 – 267MIRInterPro annotationAdd BLAST56
Domaini273 – 337MIRInterPro annotationAdd BLAST65
Domaini339 – 396MIRInterPro annotationAdd BLAST58
Domaini588 – 798B30.2/SPRYInterPro annotationAdd BLAST211
Domaini1014 – 1210B30.2/SPRYInterPro annotationAdd BLAST197
Domaini1344 – 1555B30.2/SPRYInterPro annotationAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1333 – 1371DisorderedSequence analysisAdd BLAST39
Regioni1847 – 1948DisorderedSequence analysisAdd BLAST102
Regioni3494 – 3520DisorderedSequence analysisAdd BLAST27
Regioni4270 – 4308DisorderedSequence analysisAdd BLAST39
Regioni4401 – 4545DisorderedSequence analysisAdd BLAST145

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 481Sequence analysisAdd BLAST21
Coiled coili2937 – 2957Sequence analysisAdd BLAST21
Coiled coili3685 – 3712Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1847 – 1867PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1868 – 1895AcidicSequence analysisAdd BLAST28
Compositional biasi1925 – 1945AcidicSequence analysisAdd BLAST21
Compositional biasi3497 – 3520PolyampholyteSequence analysisAdd BLAST24
Compositional biasi4270 – 4302AcidicSequence analysisAdd BLAST33
Compositional biasi4434 – 4450AcidicSequence analysisAdd BLAST17
Compositional biasi4506 – 4527PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

KEGG Orthology (KO)

More...
KOi
K04961

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6P4B8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR043136 B30.2/SPRY_sf
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6P4B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGEGGDEE IQFLRTEDQV VLQCTATVLK EQIKLCLSCE GFGNRLCFLE
60 70 80 90 100
TTSNAQNVPP DLAICSFVLE QSLSVRALQE MLANTVDMTE SSQGGGHRTL
110 120 130 140 150
LYGHAILLRH YHSSMYLSCL TTSRSLTDKL AFDVGLQLDA TGEACWWTIH
160 170 180 190 200
PASKQRSEGE KVRVGDDLIL VSVSSERYLH LSYASGDLMV DASFMQTLWN
210 220 230 240 250
MNPVCSGCEL AEGYLTGGHV LRLFHGHMDE CLAISTPDQG EEQRKIAQYE
260 270 280 290 300
GGAVCSQARS LWRLEPLRIG WSGSHMKWGQ AFRVRHITTG RYLCLDDEKG
310 320 330 340 350
LMVLDPEKAN TKQSAFSFRA SKEKVEGEKK KRDVEGMGIP EIKYGESMCF
360 370 380 390 400
MQHISTGLWL TYAALDAKAA RLGTMKRRVM LHQEGHMDDA LTCSRSQTEE
410 420 430 440 450
SQAARMIYST TGLFTQFIKG LDSLSGKNKS PGPVSLPLDG VILSLQDLIH
460 470 480 490 500
YFRPPEEELE HEEKQTKLRS LRNRQNLFQE EGMITIVLEC IDRLNVYNTA
510 520 530 540 550
AHFSEFAGEE AAESWKEIVN LLYELLASLI RGNRSNCALF CDNLDWLVSK
560 570 580 590 600
LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
610 620 630 640 650
DVLRSLCVCN GVAVRSNQNL ITENLLPGRD LLLQTNIVNY ASSVRPNIFL
660 670 680 690 700
GTCEGSTQYK KWYFEVMVDY VESFVTAQAT HLRVGWAMTE GFSPYPGGGE
710 720 730 740 750
GWGGNGVGDD LYSYGFDGLH LWSGHVSRQV ASPNQHALAA DDVVSCCLDL
760 770 780 790 800
SVPSISFRIN GHPVQGMFEN FNLDGLFFPA ISFSAGVKAR FLLGGRHGDF
810 820 830 840 850
KFLPPPGYAP CYEALLPKDR MRIEPIKEYK HDFEGVRNLL GPTQSLTHTS
860 870 880 890 900
FTPCPVDTAQ IVLPPHLERI REKLAENIHE LWAVTRIEQG WTYGVFRDDN
910 920 930 940 950
KKLHPCLVDF QSLPEPERNY NLQMSGETLK TLLALGCHVG MGDEKAEENL
960 970 980 990 1000
RKIKLPKTYV MSSGYKPAPL DLNHVKLTPN QNQLVEKLAE NGHNVWARDR
1010 1020 1030 1040 1050
VRQGWTYSIV QDIVNKRNPR LVPYNLLDER TKKTNRDSVN NAVRTLIGYG
1060 1070 1080 1090 1100
YNIEPPDQES SGHGVEDVHG DKVRIFRAEK QYGVTSGKWY FEFEAVTTGE
1110 1120 1130 1140 1150
MRVGWARPNV RSDVELGSDE LAYVFNGNRA QRWHIGNDPF GRQWQSGDVV
1160 1170 1180 1190 1200
GCMIDLIEMN IMFTLNGEML ISDSGSEMAF KDIEIGDGFI PVCTLGLSQV
1210 1220 1230 1240 1250
GRINLGQNVS SLRYFAICGL QEGFEPFAIN MKRDITMWFS KSLPQFVPVP
1260 1270 1280 1290 1300
TDHNHIEVSR VDGTVDSAPC IKITHKTFGS QNANTDMLFF RLSMPVEFHL
1310 1320 1330 1340 1350
TFKVPAGTTP LTRALTIPEE EVLEVDPDSD YEVLKKSASR KEQEEKEKEP
1360 1370 1380 1390 1400
SVPKDIPGVK ENDKDTASEK GKKKGFLFKA KKAAMITPPP PPPLMPRLIE
1410 1420 1430 1440 1450
DVVPDDRDDV DIILNTTTYY YSVRIFAGQE PSEVWVGWVT PDFHMYDLNF
1460 1470 1480 1490 1500
DLSKVRTVTV TVGDDKGNIH DSIKRSNCYM VWGGEFSSSQ QKFSQEDLVI
1510 1520 1530 1540 1550
GCLVDLATGL LNFTANGKEI NTFYQVEPNT KLFPAVFVLP SSQNMLQLEL
1560 1570 1580 1590 1600
GKLKNIMPLS AAMFRSERKN PVPQCPPRLD VQMLTPVIWS RMPNHFLNPV
1610 1620 1630 1640 1650
VGRVSERHGW MVECTEPLTM MALHIPEENR CIDILELSEQ HDLLQFHYHT
1660 1670 1680 1690 1700
LMLYCAVCAL GNNRVAHALC SHVDESQLFY AIENTYLPGP LRSGYYDLLI
1710 1720 1730 1740 1750
SIHLESAKRN RLGTNREFIV PMTSETLSIT LFPDAEAAHD LPGVGLTTCL
1760 1770 1780 1790 1800
RPKLHFSPIN FVGTDPDLYT LSPIIPLQNL KTQALSMLTE AVFDGSQAMR
1810 1820 1830 1840 1850
DPVGGSVEFH FVPILKLIST LLIMGIFNNE DVKHILKMID PSVFGKKEEA
1860 1870 1880 1890 1900
EEPAEEAAPK EEGEEVKEKE ETAEGEEEAV DEGVGEEEEE ELKELKKEEG
1910 1920 1930 1940 1950
EEGEEVEKAV EEEDGEKVDG EKAEEEKEAE EVGEEAKEEE EEAPEEGLLQ
1960 1970 1980 1990 2000
MKMPESVKLQ MCTLLQYFCD CELRHRVEAI MAYSDNFVGQ IQSNQRERYN
2010 2020 2030 2040 2050
ELMRAFTMSA AETARRTREF RSPPQEQIFL LTNFKHNPEE EDCPVPDEVR
2060 2070 2080 2090 2100
ETHNNFHNDL LNHCGVHIEE EVEEEEVDTS LRGRLLTLVD KVKSLKQKKE
2110 2120 2130 2140 2150
EEEPEPEEEP KPSTLQELIS HTMIHWAQEA FIQNPELVRL MFSLLHRQYD
2160 2170 2180 2190 2200
ALGELIRALP KAYAISAVSV QDTMEMLECL GQIRSLLIVQ MGPEEERLMI
2210 2220 2230 2240 2250
QSIGNIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGG DSKEIRFPQM
2260 2270 2280 2290 2300
VTNCCRFLCY FCRISRQNQR SMFDHLSYLL QNSGIGLGMR GSTPLDVAAA
2310 2320 2330 2340 2350
SCIDNNELAL ALQEQDLEMV VTYLAGCGLR MCPMLLSKGY PDIGWNPGGG
2360 2370 2380 2390 2400
ERYLDFLRFA VFVNGESVEE NANVVVRLLI RRPECFGPAL RGEGGAGLLA
2410 2420 2430 2440 2450
AIEEAIKISE DPARDGPTPK KDRRFMFGGE DQHEENRLHL GNAIMSFYSA
2460 2470 2480 2490 2500
LIDLLGRCAP EMHLIQAGKG EALRIRAILR SLVPIEDLVG VISLPVQIPT
2510 2520 2530 2540 2550
FGKDGQIVEP KMSASFVPDH KASMVLFLDR VYGIDNQDFL LHVLEVGFLP
2560 2570 2580 2590 2600
DMRASASLDT VAFSTTEMAL ALNRYLCSAV LPLLTKCAPL FAGTDHRAIM
2610 2620 2630 2640 2650
IDSMLHTIYR LSRGRALTKA QRDVIEDCLM SLVKYLRPSM LQHLLRRLVF
2660 2670 2680 2690 2700
DVPILNEYAK MPLKLLTNHY ERCWKYYCLP NGWANFGVTS EEELHLSRKL
2710 2720 2730 2740 2750
FWGIFESLAH KKFDAELFKI AMPCICAIAG AIPPDYVDAS YSSMTEKKAS
2760 2770 2780 2790 2800
VDAEGNFDPK PVETTNTIIP ERLDAFINKY AEHTHDKWAF EKIQNNWTYG
2810 2820 2830 2840 2850
EVLDENAKTH PMLRPYKTFS EKDKEIYRWP IKESIKAMLA WEWTLEKARD
2860 2870 2880 2890 2900
GETEVKTEVK ATRKISQTAQ ATYDPSQGYS PQPVDLIGMA LSRELQSMAE
2910 2920 2930 2940 2950
QLAENYHNTW GRKKKMELQA KGGGTHPLLV PYDTLTAKEK ARDREKAQDL
2960 2970 2980 2990 3000
LKFLQLNGYA VTRGLKDMEQ EISSIEKRFA YGFLQKLLKW MEIAQEFIAH
3010 3020 3030 3040 3050
LEAVVSSGRV EKSPHEQEIK FFAKILLPLI NQYFKNHCLY FLSTPAKVLG
3060 3070 3080 3090 3100
SGGHASNKEK EMIASIFCKL AGLVRHRVSL FGTDASAVVN CLHILSRSLD
3110 3120 3130 3140 3150
ARTVMKSGPE IVKAGLRSFF ESAADDIEKM VENLKLGKVS TKNQVKGVSQ
3160 3170 3180 3190 3200
NISYTTTALL PVLTSLFDHI AQHQFGDDVM LDDLQISCYR IMCSIYSLGT
3210 3220 3230 3240 3250
VKTPHAENQR PALGECLAHL AAAMPVAFLE PNLNEFNSYS VYTTKTPRER
3260 3270 3280 3290 3300
TILGLPSQVQ ELCLDIPELD VLMKEIGHLA ESGARYTEMP HVIEITLPML
3310 3320 3330 3340 3350
CNYLPRWWER GPENFPEQEG CLCTDVTSEQ LNQLLGSIMK IVVNNLGIDE
3360 3370 3380 3390 3400
ASWMKRLAVF AQPIVSRAKP EMLKSHFIPT MEKLKKRSGK VVAEEEQLRM
3410 3420 3430 3440 3450
EGKTEVDSEG GTIRDEFAVL CRDLYALYPL LIRYVDNNRA RWLTCPDPDA
3460 3470 3480 3490 3500
EDLFRMVGEV FIFWSKSHNF KREEQNFVVM NEINNMSFLT ADSKSKMSKA
3510 3520 3530 3540 3550
GDGEGGGSDD DRTKKKRRGD RYSVQTSLIV AALKKLLPIG LNMCSPADQE
3560 3570 3580 3590 3600
LINLAKIRYS LKDTDEEVRE FLQNNLHLQG KVEDPSMRWQ MALYKETSGK
3610 3620 3630 3640 3650
AEDADAPEKV VKRVQEVSAV LYHLELTEHP YKSKKMVWHK LLSKQRRRAV
3660 3670 3680 3690 3700
VACFRMTPLY NIPRHRASNM FLDGYKRNWL ENEGYSFEDK MIDDLSKALE
3710 3720 3730 3740 3750
QEEEEEEETE SKPDPLHQLI LHFSRTALTE KLKLEVDHLY MSYADIMAKS
3760 3770 3780 3790 3800
CHIGEEDEGG EEGGVEPSFE VRQTEMEKEM EKQRLLYQQS RLHDRGAAEM
3810 3820 3830 3840 3850
VLQMISACKG ETGVMVSSTL KLGISILNGG NSDVQQRMLD YLKDKKDVGF
3860 3870 3880 3890 3900
FLSLQALMQT CSVLDLNAFE RQNKAEGLGM VSEEGTKEKV MADDEFTCDL
3910 3920 3930 3940 3950
FRFLQLLCEG HNNDFQNYLR TQTGSTTTIN IIICTVDFLL RLQESISDFY
3960 3970 3980 3990 4000
WYYSGKDIID EPGKRNFSKA MTVAKQVFNS LTEYIQGPCT GNQQSLAHSR
4010 4020 4030 4040 4050
LWDAVVGFLH VFAHMMMKLA QDSSQIGLLK ELLDLQKDMV VMLLSLLEGN
4060 4070 4080 4090 4100
VVNGTIARQM VDMLVESSSN VEMILKFFDM FLKLKDIVAS DAFRDYVTDP
4110 4120 4130 4140 4150
RGLISKKDFS KAMDSQKQYT PSEIQFLLSC SEADENEMIN FEEFANRFQE
4160 4170 4180 4190 4200
PAKDIGFNIA VLLTNLSEHV PHDTRLQNFL EQAESVLNYF RPFLGRIEIM
4210 4220 4230 4240 4250
GASKRIERIY FEISEANRNQ WEMPQVRESK RQFIFDVVNE GGESEKMELF
4260 4270 4280 4290 4300
VNFCEDTIFE MNIASQISEQ EEEVIEDEDE EEEEESGGGG GGEGEGEEGN
4310 4320 4330 4340 4350
GEEAPPESSS AFADFIKSIV NFLSLFTFRN LRRRYRKIRK MTIKDMIVGL
4360 4370 4380 4390 4400
VMFLYTVLFG ILHFIYSVCK GFFLLIWNTL FGGGLVEGAK KMTLTEILTN
4410 4420 4430 4440 4450
MPDPTQDEVH GDLPPEPGAR KVQEAGGAGE GEEGAGGGEE EAEEGEEDED
4460 4470 4480 4490 4500
GRAGFGPHGG LGDMGETEPE EPPTPEGSPL LKRKLVSEEG GEGEVVVEEE
4510 4520 4530 4540 4550
KVEEEPAPEP EKADAENGEK EKEAEPETED KQEEEQAEIA KAKAKAKKGK
4560 4570 4580 4590 4600
KEEEVGFELW NELEIQRIKF MNYLSRNFYN LRFLALFIAF ALNFILLFYK
4610 4620 4630 4640 4650
VSDRLPGEEE EFEGSAMFEG SGAFEGSAVF EGSAVFEGSG VFEGSGEAEG
4660 4670 4680 4690 4700
SGMEENGEED EENGFVYYFL EESTGYMEPA MAFFSILHTI ISFLCIIGYN
4710 4720 4730 4740 4750
CLKVPLVIFK REKELARKLE FDGLYVTEQP EDDDIKGQWD RLVLNTPSFP
4760 4770 4780 4790 4800
NNYWDKFVKR KVLEKYGDIY GRERIAELLG MDLASLDVSA MTHEKKRQPD
4810 4820 4830 4840 4850
PSMFTWLTSI DIKYQIWKFG VVFTDNTFLY LVWYTVMSLL GHFNNFFFAC
4860 4870 4880 4890 4900
HLLDIAMGVK TLRTILSSVT HNGKQLLMTV GLLAVVVYLY TVVAFNFFRK
4910 4920 4930 4940 4950
FYNMSEDEDE PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI EDPAGDEYEL
4960 4970 4980 4990 5000
YRVVFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVR EDMETKCFIC
5010 5020 5030 5040 5050
GIGSDYFDST PHGFETHTME EHNLANYMFF LMYLINKDET EHTGQESYVW
5060 5070
KMYQERCWDF FPAGDCFRKQ YEDQLG
Length:5,076
Mass (Da):574,755
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD8F0A35ECB9EA92
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB247454 mRNA Translation: BAF73476.1

NCBI Reference Sequences

More...
RefSeqi
NP_001096041.1, NM_001102571.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
570245

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:570245

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB247454 mRNA Translation: BAF73476.1
RefSeqiNP_001096041.1, NM_001102571.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA6P4B8

Genome annotation databases

GeneIDi570245
KEGGidre:570245

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
570245
ZFINiZDB-GENE-070705-417 ryr1b

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
KOiK04961
OrthoDBi5161at2759
PhylomeDBiA6P4B8

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR043136 B30.2/SPRY_sf
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6P4B8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6P4B8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 17, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again