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Protein

Nuclear receptor coactivator

Gene

Ncoa2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, ReceptorImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivatorUniRule annotation
Gene namesi
Name:Ncoa2Imported
Synonyms:GRIP1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1276533 Ncoa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiA6P3E3

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ELMiA6P3E3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 83BHLHInterPro annotationAdd BLAST58
Domaini119 – 183PASInterPro annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 100Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000230947
HOVERGENiHBG052583

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 2 hits
PTHR10684:SF2 PTHR10684:SF2, 2 hits
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 2 hits
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

A6P3E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA
60 70 80 90 100
DLIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS
110 120 130 140 150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGSVVFVS ENVTQYLRYN
160 170 180 190 200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWSGEP PRRTSHTFNC
210 220 230 240 250
RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE EGEDLQSCLI
260 270 280 290 300
CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV
310 320 330 340 350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ
360 370 380 390 400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS
410 420 430 440 450
SSPAHQALCS GNPGQDMTLG SNINFPMNGP KEQMGMPMGR FGGSGGMNHV
460 470 480 490 500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QASSVLSPRQ RMSPGVAGSP
510 520 530 540 550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS
560 570 580 590 600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA
610 620 630 640 650
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD
660 670 680 690 700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP
710 720 730 740 750
VDLAKLTAEA TGKELSQESS STAPGSEVTV KQEPASPKKK ENALLRYLLD
760 770 780 790 800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG
810 820 830 840 850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS
860 870 880 890 900
SPVPPAGAQK AALRMSQSRM IGSSTSRPSM PSGEWAPQSP AVRVTCAATT
910 920 930 940 950
GAMNRPVQGG MIRNPTASIP MRANSQPGQR QMLQSQVMNI GPSELEMNMG
960 970 980 990 1000
GPQYNQQQAP PNQTAPWPES ILPIDQASFA SQNRQPFGSS PDDLLCPHPA
1010 1020 1030 1040 1050
AESPSDEGAL LDQLYLALRN FDGLEEIDRA LGIPELVSQS QAVDAEQFSS
1060 1070 1080 1090 1100
QESSIMLEQK PPVFPQQYAS QAQMAQGGYN PMQDPNFHTM GQRPNYTTLR
1110 1120 1130 1140 1150
MQPRPGLRPT GIVQNQPNQL RLQLQHRLQA QQNRQPLMNQ ISSVSNVNLT
1160 1170 1180 1190 1200
LRPGVPTQAP INAQMLAQRQ REILNQHLRQ RQMQQQVQQR TLMMRGQGLN
1210 1220 1230 1240 1250
VTPSMVAPAG LPAAMSNPRI PQANAQQFPF PPNYGISQQP DPGFTGATTP
1260 1270 1280 1290 1300
QSPLMSPRMA HTQSPMMQQS QANPAYQPTS DMNGWAQGSM GGNSMFSQQS
1310 1320 1330 1340 1350
PPHFGQQANT SMYSNNMNIS VSMATNTGGL SSMNQMTCQM SMTSVTSVPT
1360 1370 1380 1390
SGLPSMGPEQ VNDPALRGGN LFPNQLPGMD MIKQEGDASR KYC
Length:1,393
Mass (Da):151,400
Last modified:August 21, 2007 - v1
Checksum:iFE37BDD284461E53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219976 mRNA Translation: BAF69036.1
UniGeneiMm.2537

Similar proteinsi

Entry informationi

Entry nameiA6P3E3_MOUSE
AccessioniPrimary (citable) accession number: A6P3E3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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