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UniProtKB - A6NP61 (ZAR1L_HUMAN)

Entry version 96 (07 Apr 2021)
Sequence version 2 (15 Jan 2008)
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Protein

ZAR1-like protein

Gene

ZAR1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A6NP61

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ZAR1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZAR1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:37116, ZAR1L

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NP61

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000189167.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		646799

Open Targets

More...OpenTargetsi		ENSG00000189167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165505636

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NP61, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZAR1L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322271 – 321ZAR1-like proteinAdd BLAST321

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NP61

PeptideAtlas

More...PeptideAtlasi		A6NP61

PRoteomics IDEntifications database

More...PRIDEi		A6NP61

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1661

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NP61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NP61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000189167, Expressed in thoracic aorta and 18 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000189167, Tissue enhanced (brain, gallbladder, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		571620, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000437289

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NP61, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZAR1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWC9, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012305

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053350_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NP61

Identification of Orthologs from Complete Genome Data

More...OMAi		GCSQTCC

Database of Orthologous Groups

More...OrthoDBi		822936at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NP61

TreeFam database of animal gene trees

More...TreeFami		TF331383

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026775, Zar1
IPR027377, Znf-3CxxC

The PANTHER Classification System

More...PANTHERi		PTHR31054, PTHR31054, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13695, zf-3CxxC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01328, zf-3CxxC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NP61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERFVRVPYG LYQGYGSTVP LGQPGLSGHK QPDWRQNMGP PTFLARPGLL 
        60         70         80         90        100
VPANAPDYCI DPYKRAQLKA ILSQMNPSLS PRLCKPNTKE VGVQVSPRVD 
       110        120        130        140        150
KAVQCSLGPR TLSSCSPWDG RDPQEPLPAC GVTSPATGRR GLIRLRRDGD 
       160        170        180        190        200
EAESKALPGP AEASQPQPPS RRSGADRQEE PGQLEESGEK DAPCPQETKS 
       210        220        230        240        250
KQVPGDAASE PLRRPNFQFL EPKYGYFHCK DCKTRWESAY VWCISGTNKV 
       260        270        280        290        300
YFKQLCCKCQ KSFNPYRVEA IQCQTCSKSH CSCPQKKRHI DLRRPHRQEL 
       310        320 
CGRCKDKRFS CGNIYSFKYV M
Length:321
Mass (Da):36,010
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5229FDB8FD581BC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL445212 Genomic DNA No translation available.
BC146956 mRNA Translation: AAI46957.1
BC146965 mRNA Translation: AAI46966.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45023.1

NCBI Reference Sequences

More...RefSeqi		NP_001130043.1, NM_001136571.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000345108; ENSP00000344616; ENSG00000189167
ENST00000533490; ENSP00000437289; ENSG00000189167

Database of genes from NCBI RefSeq genomes

More...GeneIDi		646799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:646799

UCSC genome browser

More...UCSCi		uc010abc.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445212 Genomic DNA No translation available.
BC146956 mRNA Translation: AAI46957.1
BC146965 mRNA Translation: AAI46966.1
CCDSiCCDS45023.1
RefSeqiNP_001130043.1, NM_001136571.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi571620, 17 interactors
STRINGi9606.ENSP00000437289

PTM databases

iPTMnetiA6NP61
PhosphoSitePlusiA6NP61

Genetic variation databases

BioMutaiZAR1L

Proteomic databases

PaxDbiA6NP61
PeptideAtlasiA6NP61
PRIDEiA6NP61
ProteomicsDBi1661

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49134, 41 antibodies

Genome annotation databases

EnsembliENST00000345108; ENSP00000344616; ENSG00000189167
ENST00000533490; ENSP00000437289; ENSG00000189167
GeneIDi646799
KEGGihsa:646799
UCSCiuc010abc.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		646799
DisGeNETi646799

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZAR1L
HGNCiHGNC:37116, ZAR1L
HPAiENSG00000189167, Tissue enhanced (brain, gallbladder, testis)
neXtProtiNX_A6NP61
OpenTargetsiENSG00000189167
PharmGKBiPA165505636
VEuPathDBiHostDB:ENSG00000189167.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWC9, Eukaryota
GeneTreeiENSGT00390000012305
HOGENOMiCLU_053350_1_0_1
InParanoidiA6NP61
OMAiGCSQTCC
OrthoDBi822936at2759
PhylomeDBiA6NP61
TreeFamiTF331383

Enzyme and pathway databases

PathwayCommonsiA6NP61

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		646799, 9 hits in 978 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZAR1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		646799
PharosiA6NP61, Tdark

Protein Ontology

More...PROi		PR:A6NP61
RNActiA6NP61, protein

Gene expression databases

BgeeiENSG00000189167, Expressed in thoracic aorta and 18 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026775, Zar1
IPR027377, Znf-3CxxC
PANTHERiPTHR31054, PTHR31054, 1 hit
PfamiView protein in Pfam
PF13695, zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328, zf-3CxxC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZAR1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NP61
Secondary accession number(s): B2RV03, B7ZBU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 15, 2008
Last modified: April 7, 2021
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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