Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 716

Gene

ZNF716

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 207C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 290C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 716
Gene namesi
Name:ZNF716
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000182111.8
HGNCiHGNC:32458 ZNF716
neXtProtiNX_A6NP11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182111

Polymorphism and mutation databases

BioMutaiZNF716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188551 – 495Zinc finger protein 716Add BLAST495

Proteomic databases

EPDiA6NP11
MaxQBiA6NP11
PaxDbiA6NP11
PRIDEiA6NP11
ProteomicsDBi1652

PTM databases

iPTMnetiA6NP11
PhosphoSitePlusiA6NP11

Expressioni

Gene expression databases

BgeeiENSG00000182111 Expressed in 1 organ(s), highest expression level in testis
CleanExiHS_ZNF716

Interactioni

Protein-protein interaction databases

BioGridi137285, 1 interactor
STRINGi9606.ENSP00000394248

Structurei

3D structure databases

ProteinModelPortaliA6NP11
SMRiA6NP11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 207C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 290C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA6NP11
KOiK09228
OMAiVKKCCKS
OrthoDBiEOG091G02KC
PhylomeDBiA6NP11
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

A6NP11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKEPQNIKRN EMVAKHPVTC SHFTQDLQSE
110 120 130 140 150
QGIKDSLQKV ILRRYGKCGQ EDLQVKKCCK SVGECEVHKG GYNYVNQCLS
160 170 180 190 200
ATQNKTFQTH KCVKVFGKFS NSNRHKTRHT GKKHFKCKND GKSFCMLSRL
210 220 230 240 250
NQHQIIHTRE KSYKCEECGK SFNCSSTLTR HKRIHTGEKP YRCEECGKAF
260 270 280 290 300
SWSASLTKHK RIHTGEKPYT CEERGKVFSR STLTNYKRIH TGEKPYTCEE
310 320 330 340 350
CGKAFSRSST LTNHKRIHTG ERPYKCEECG KAFSLSSTLK KHKIVHTGEK
360 370 380 390 400
LYTCEECGKA FTFSSTLNTH KRIHTGEKPY TCEECGKAFS LPSTFTYHKR
410 420 430 440 450
THTGEKPYKC EECGKAFNCS STLKKHKIIH TGEKLYKCKE CGKAFTFSST
460 470 480 490
LNTHKRIHTG EKPYKCEECD QTFKWHSSLA NHKNMHTGEK PYKYE
Length:495
Mass (Da):57,006
Last modified:March 21, 2012 - v4
Checksum:i0EDE6E44362C630A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131575 mRNA No translation available.
AC092175 Genomic DNA No translation available.
CCDSiCCDS55112.1
RefSeqiNP_001152751.1, NM_001159279.1
UniGeneiHs.533121

Genome annotation databases

EnsembliENST00000420713; ENSP00000394248; ENSG00000182111
GeneIDi441234
KEGGihsa:441234
UCSCiuc011kdi.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131575 mRNA No translation available.
AC092175 Genomic DNA No translation available.
CCDSiCCDS55112.1
RefSeqiNP_001152751.1, NM_001159279.1
UniGeneiHs.533121

3D structure databases

ProteinModelPortaliA6NP11
SMRiA6NP11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137285, 1 interactor
STRINGi9606.ENSP00000394248

PTM databases

iPTMnetiA6NP11
PhosphoSitePlusiA6NP11

Polymorphism and mutation databases

BioMutaiZNF716

Proteomic databases

EPDiA6NP11
MaxQBiA6NP11
PaxDbiA6NP11
PRIDEiA6NP11
ProteomicsDBi1652

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420713; ENSP00000394248; ENSG00000182111
GeneIDi441234
KEGGihsa:441234
UCSCiuc011kdi.2 human

Organism-specific databases

CTDi441234
EuPathDBiHostDB:ENSG00000182111.8
GeneCardsiZNF716
HGNCiHGNC:32458 ZNF716
neXtProtiNX_A6NP11
OpenTargetsiENSG00000182111
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA6NP11
KOiK09228
OMAiVKKCCKS
OrthoDBiEOG091G02KC
PhylomeDBiA6NP11
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF716 human
GenomeRNAii441234
PROiPR:A6NP11

Gene expression databases

BgeeiENSG00000182111 Expressed in 1 organ(s), highest expression level in testis
CleanExiHS_ZNF716

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN716_HUMAN
AccessioniPrimary (citable) accession number: A6NP11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 21, 2012
Last modified: November 7, 2018
This is version 94 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again