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UniProtKB - A6NNT2 (CP096_HUMAN)

Entry version 80 (02 Dec 2020)
Sequence version 3 (19 Oct 2011)
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Protein

Uncharacterized protein C16orf96

Gene

C16orf96

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A6NNT2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C16orf96Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C16orf96Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000205832.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:40031, C16orf96

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NNT2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		342346

Open Targets

More...OpenTargetsi		ENSG00000205832

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NNT2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C16orf96

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003456281 – 1141Uncharacterized protein C16orf96Add BLAST1141

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A6NNT2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NNT2

PeptideAtlas

More...PeptideAtlasi		A6NNT2

PRoteomics IDEntifications database

More...PRIDEi		A6NNT2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1635

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NNT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NNT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000205832, Expressed in testis and 46 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000205832, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131169, 2 interactors

Protein interaction database and analysis system

More...IntActi		A6NNT2, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000415027

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NNT2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A6NNT2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 101Sequence analysisAdd BLAST28
Coiled coili145 – 176Sequence analysisAdd BLAST32
Coiled coili757 – 810Sequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi306 – 440Pro-richAdd BLAST135
Compositional biasi568 – 614Ala-richAdd BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RC3N, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_283220_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NNT2

Identification of Orthologs from Complete Genome Data

More...OMAi		VNTKLVH

Database of Orthologous Groups

More...OrthoDBi		430976at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NNT2

TreeFam database of animal gene trees

More...TreeFami		TF339506

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032013, DUF4795

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16043, DUF4795, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NNT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFSLTFTEL ANIAIPQCGV LNFKALHLLL HGILEHIHMA ELKKVLSGDE 
        60         70         80         90        100
DFLQTSQVVI MPREGDAQPI LNPMKRLSNV FDHVVSRLDK LENQLALLQD 
       110        120        130        140        150
LPSTAQLLEA SQGTARPVQD LWHLIKLRKM VEGHDEVMAK SMQTLQDLLT 
       160        170        180        190        200
DLHALQVTIT ALRKEVDMLK NMLDKVHPER MDIFAEDFKI QNWKMVALQR 
       210        220        230        240        250
EVASLQNKFK TIPKTEDMVL WSGLHDAMFT SEIGSSPLDL WQSVEQLPEA 
       260        270        280        290        300
ALAQTTKYLE ATRAIQVSEP VQNPQLLQTV WHYEVPELLP EGSSAQAVSL 
       310        320        330        340        350
SRAQEPAQPP ALTPESAPGC TTEFAPGPAP GTEPVPGLEL GLELEPVPAL 
       360        370        380        390        400
GPVPGPSVTP GSLPAPWPVL GPVPAPGAQP PPLGDWPALP RRWPLPQGWP 
       410        420        430        440        450
RVGSWPLWDL GVLRPTQPQP SRAPPPATEF GSLWPRPLQP YQSRQGEALQ 
       460        470        480        490        500
LAAVQVKGEE NDVPSLRGLR ERARKDGAPK DRTRKDGVPK DRGGKDVDPK 
       510        520        530        540        550
DRAHKDDVPK DRGGKDVDPK DRAHKDDVPK DRGGKDGDPK DRVGKDGAPK 
       560        570        580        590        600
EAQPKAPQSA LHRLKTTAAI AAAAAAAYAA ATSSAAQAAK VAAKFVKDAP 
       610        620        630        640        650
ATKMAAIATD TAAAGPLGVF ADVLGAGPSR GATESQILGD DSEIYEILSP 
       660        670        680        690        700
SYSAASIGPD PALSQAMVAT KQAMSPEDKK RAVKYSMSHI AQIPVKHDSL 
       710        720        730        740        750
KEEFAQLSCN LNQRLSYLAN MGGPSSLGTT VDILQKKIGS LQKSRLKEEE 
       760        770        780        790        800
LERIWGNQIE MMKDRYITLD KAVENLQIRM DEFKTLQAQI KRLEMNKVNK 
       810        820        830        840        850
STMEEELREK ADRSALAGKA SRVDLETVAL ELNEMIQGIL FKVTIHEDSW 
       860        870        880        890        900
KKAMEELSKD VNTKLVHSDL DPLKKEMEEV WKIVRKLLIE GLRLDPDSAA 
       910        920        930        940        950
GFRRKLFKRV KCISCDRPVE MMTGPQLITI RKAHLLSRLR PASANSCEYL 
       960        970        980        990       1000
QRQQMREQQW LQLQDLGIQE DCQQDWGDGP QNATSLKCKS CNLLTLYPYG 
      1010       1020       1030       1040       1050
DPHVIDYDSA EVDILGVDGI LYKGRVNSQR GAQPLAVAKE LAAVKAPSPP 
      1060       1070       1080       1090       1100
SQSLYDRVHS SALFGAICPP LCPRSSACSA ASGPHLTMPA RPPSLPPLLL 
      1110       1120       1130       1140 
LPPLIPSLRD PQQAPGSTRL SRAPHIESRV GRKPPEEPAN P
Length:1,141
Mass (Da):125,041
Last modified:October 19, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EC01FC5481CC306
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC023830 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53986.1

NCBI Reference Sequences

More...RefSeqi		NP_001138483.1, NM_001145011.1
XP_011520777.1, XM_011522475.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000444310; ENSP00000415027; ENSG00000205832

Database of genes from NCBI RefSeq genomes

More...GeneIDi		342346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:342346

UCSC genome browser

More...UCSCi		uc010uxn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023830 Genomic DNA No translation available.
CCDSiCCDS53986.1
RefSeqiNP_001138483.1, NM_001145011.1
XP_011520777.1, XM_011522475.2

3D structure databases

SMRiA6NNT2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131169, 2 interactors
IntActiA6NNT2, 1 interactor
STRINGi9606.ENSP00000415027

PTM databases

iPTMnetiA6NNT2
PhosphoSitePlusiA6NNT2

Polymorphism and mutation databases

BioMutaiC16orf96

Proteomic databases

MassIVEiA6NNT2
PaxDbiA6NNT2
PeptideAtlasiA6NNT2
PRIDEiA6NNT2
ProteomicsDBi1635

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51179, 8 antibodies

Genome annotation databases

EnsembliENST00000444310; ENSP00000415027; ENSG00000205832
GeneIDi342346
KEGGihsa:342346
UCSCiuc010uxn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		342346
DisGeNETi342346
EuPathDBiHostDB:ENSG00000205832.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		C16orf96
HGNCiHGNC:40031, C16orf96
HPAiENSG00000205832, Tissue enriched (testis)
neXtProtiNX_A6NNT2
OpenTargetsiENSG00000205832

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RC3N, Eukaryota
GeneTreeiENSGT00940000162979
HOGENOMiCLU_283220_0_0_1
InParanoidiA6NNT2
OMAiVNTKLVH
OrthoDBi430976at2759
PhylomeDBiA6NNT2
TreeFamiTF339506

Enzyme and pathway databases

PathwayCommonsiA6NNT2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		342346, 6 hits in 831 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C16orf96, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		342346
PharosiA6NNT2, Tdark

Protein Ontology

More...PROi		PR:A6NNT2
RNActiA6NNT2, protein

Gene expression databases

BgeeiENSG00000205832, Expressed in testis and 46 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR032013, DUF4795
PfamiView protein in Pfam
PF16043, DUF4795, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP096_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NNT2
Secondary accession number(s): C9JH24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 19, 2011
Last modified: December 2, 2020
This is version 80 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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