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Entry version 75 (13 Feb 2019)
Sequence version 2 (29 Apr 2008)
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Protein

Uncharacterized protein C15orf61

Gene

C15orf61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C15orf61
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000189227.5

Human Gene Nomenclature Database

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HGNCi
HGNC:34453 C15orf61

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NNL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000189227

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162378286

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C15orf61

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033274027 – 157Uncharacterized protein C15orf61Add BLAST131

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NNL5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NNL5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NNL5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NNL5

PRoteomics IDEntifications database

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PRIDEi
A6NNL5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1617

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NNL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NNL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189227 Expressed in 211 organ(s), highest expression level in deltoid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NNL5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NNL5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062820

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126948, 4 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A6NNL5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NNL5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IXFI Eukaryota
ENOG4111KDN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247035

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG091232

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NNL5

Identification of Orthologs from Complete Genome Data

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OMAi
GPITIYF

Database of Orthologous Groups

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OrthoDBi
1465932at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NNL5

TreeFam database of animal gene trees

More...
TreeFami
TF332748

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029245 DUF4528

The PANTHER Classification System

More...
PANTHERi
PTHR34651 PTHR34651, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15031 DUF4528, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6NNL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEALRRAHEV ALRLLLCRPW ASRAAARPKP SASEVLTRHL LQRRLPHWTS
60 70 80 90 100
FCVPYSAVRN DQFGLSHFNW PVQGANYHVL RTGCFPFIKY HCSKAPWQDL
110 120 130 140 150
ARQNRFFTAL KVVNLGIPTL LYGLGSWLFA RVTETVHTSY GPITVYFLNK

EDEGAMY
Length:157
Mass (Da):18,091
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12E035D8F2FA5A90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN13H0YN13_HUMAN
Uncharacterized protein C15orf61
C15orf61
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK294012 mRNA Translation: BAG57373.1
AC016355 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77798.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45289.1

NCBI Reference Sequences

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RefSeqi
NP_001137408.1, NM_001143936.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.438385

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342683; ENSP00000342254; ENSG00000189227

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
145853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:145853

UCSC genome browser

More...
UCSCi
uc002aqs.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294012 mRNA Translation: BAG57373.1
AC016355 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77798.1
CCDSiCCDS45289.1
RefSeqiNP_001137408.1, NM_001143936.1
UniGeneiHs.438385

3D structure databases

ProteinModelPortaliA6NNL5
SMRiA6NNL5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126948, 4 interactors

PTM databases

iPTMnetiA6NNL5
PhosphoSitePlusiA6NNL5

Polymorphism and mutation databases

BioMutaiC15orf61

Proteomic databases

EPDiA6NNL5
jPOSTiA6NNL5
MaxQBiA6NNL5
PaxDbiA6NNL5
PRIDEiA6NNL5
ProteomicsDBi1617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342683; ENSP00000342254; ENSG00000189227
GeneIDi145853
KEGGihsa:145853
UCSCiuc002aqs.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
145853
EuPathDBiHostDB:ENSG00000189227.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C15orf61
HGNCiHGNC:34453 C15orf61
HPAiHPA062820
neXtProtiNX_A6NNL5
OpenTargetsiENSG00000189227
PharmGKBiPA162378286

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXFI Eukaryota
ENOG4111KDN LUCA
GeneTreeiENSGT00390000015942
HOGENOMiHOG000247035
HOVERGENiHBG091232
InParanoidiA6NNL5
OMAiGPITIYF
OrthoDBi1465932at2759
PhylomeDBiA6NNL5
TreeFamiTF332748

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
145853

Protein Ontology

More...
PROi
PR:A6NNL5

Gene expression databases

BgeeiENSG00000189227 Expressed in 211 organ(s), highest expression level in deltoid
ExpressionAtlasiA6NNL5 baseline and differential
GenevisibleiA6NNL5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029245 DUF4528
PANTHERiPTHR34651 PTHR34651, 1 hit
PfamiView protein in Pfam
PF15031 DUF4528, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO061_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NNL5
Secondary accession number(s): B4DFB2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 13, 2019
This is version 75 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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