Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 105 (08 May 2019)
Sequence version 4 (14 May 2014)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Zinc finger protein 726

Gene

ZNF726

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 645C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri651 – 673C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 726
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF726
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32462 ZNF726

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NNF4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000213967

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF726

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003406821 – 738Zinc finger protein 726Add BLAST738

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NNF4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NNF4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NNF4

PRoteomics IDEntifications database

More...
PRIDEi
A6NNF4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1605
1606 [A6NNF4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NNF4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NNF4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213967 Expressed in 85 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NNF4 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PFDN2Q9UHV94EBI-18338284,EBI-359873

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
610475, 6 interactors

Protein interaction database and analysis system

More...
IntActi
A6NNF4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000471516

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NNF4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 645C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri651 – 673C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NNF4

KEGG Orthology (KO)

More...
KOi
K09228

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NNF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLTFRDVA IEFSLEEWQC LDTAQKNLYR NVMLENYRNL AFLGIAVSKP
60 70 80 90 100
DLIICLEKEK EPWNMKRDEM VDEPPGICPH FAQDIWPEQG VEDSFQKVIL
110 120 130 140 150
RRFEKCGHEN LQLRKGCKSV DECKVHKEGY NGLNQCFTTT QGKASQCGKY
160 170 180 190 200
LKVFYKFINL NRYKIRHTRK KPFKCKNCVK SFCMFSHKTQ HKSIYTTEKS
210 220 230 240 250
YKCKECGKTF NWSSTLTNHK KTHTEEKPYK CEEYGKAFNQ SSNYTTHKVT
260 270 280 290 300
HTGEKPYKCE ECGKAFSQSS TLTIHKRIHT GEKPCKCEEC GKAFSQPSAL
310 320 330 340 350
TIHKRMHIGE KPYKCEECGK AFVWSSTLTR HKRLHSGEKP YKCEECAKAF
360 370 380 390 400
SQFGHLTTHR IIHTGEKPYK CEECGKAFIW PSTLTKHKRI HTGEKPYKCE
410 420 430 440 450
ECGKAFHRSS NLTKHKIIHT GEKPYKCEEC GKAFIWSSNL TEHKKIHTRE
460 470 480 490 500
KPYKCEECSK AFSRSSALTT HKRMHTGEKP YKCEECGKAF SQSSTLTAHK
510 520 530 540 550
IIHTGEKPYK CEECGKAFIL SSTLSKHKRI HTGEKPYKCE ECGKTFNQSS
560 570 580 590 600
NLSTHKIIHT GEKPYKCEEC GKAFNRSSNL STHKIIHTGE KPYKCDECGK
610 620 630 640 650
SFIWSSTLFK HKRIHTGEKP YKCEECGKAF NHSQILLHIR HKRMHTGEKP
660 670 680 690 700
YKCEECGKSF NLSSTFIKHK VIHTGVKLYK CEECGKVFFW SSALTRHKKI
710 720 730
HAGQQPYKWE KIGKAFNQSS HLTTDKITHI GEKSYKCE
Length:738
Mass (Da):85,539
Last modified:May 14, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB6F0803DAC4FA22
GO
Isoform 2 (identifier: A6NNF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-77: I → R
     78-738: Missing.

Show »
Length:77
Mass (Da):9,077
Checksum:i2DDCCB4AFC94C2BA
GO
Isoform 3 (identifier: A6NNF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-738: Missing.

Show »
Length:616
Mass (Da):71,359
Checksum:iF93DB0E02A2C04DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR41A0A0A0MR41_HUMAN
Zinc finger protein 726
ZNF726
738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLI7E9PLI7_HUMAN
Zinc finger protein 726
ZNF726
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1T0F3F1T0F3_HUMAN
Zinc finger protein 726
ZNF726
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNQ9J3KNQ9_HUMAN
Zinc finger protein 726
ZNF726
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03421677I → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_03421778 – 738Missing in isoform 2. 1 PublicationAdd BLAST661
Alternative sequenceiVSP_054850617 – 738Missing in isoform 3. CuratedAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011503 Genomic DNA No translation available.
BC046415 mRNA Translation: AAH46415.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59372.1 [A6NNF4-3]
CCDS86739.1 [A6NNF4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001230967.1, NM_001244038.1 [A6NNF4-3]
NP_001335618.1, NM_001348689.1 [A6NNF4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000531821; ENSP00000432583; ENSG00000213967 [A6NNF4-2]
ENST00000594466; ENSP00000471516; ENSG00000213967 [A6NNF4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
730087

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:730087

UCSC genome browser

More...
UCSCi
uc021urw.2 human [A6NNF4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011503 Genomic DNA No translation available.
BC046415 mRNA Translation: AAH46415.2
CCDSiCCDS59372.1 [A6NNF4-3]
CCDS86739.1 [A6NNF4-2]
RefSeqiNP_001230967.1, NM_001244038.1 [A6NNF4-3]
NP_001335618.1, NM_001348689.1 [A6NNF4-2]

3D structure databases

SMRiA6NNF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi610475, 6 interactors
IntActiA6NNF4, 1 interactor
STRINGi9606.ENSP00000471516

PTM databases

iPTMnetiA6NNF4
PhosphoSitePlusiA6NNF4

Polymorphism and mutation databases

BioMutaiZNF726

Proteomic databases

EPDiA6NNF4
jPOSTiA6NNF4
PaxDbiA6NNF4
PRIDEiA6NNF4
ProteomicsDBi1605
1606 [A6NNF4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531821; ENSP00000432583; ENSG00000213967 [A6NNF4-2]
ENST00000594466; ENSP00000471516; ENSG00000213967 [A6NNF4-3]
GeneIDi730087
KEGGihsa:730087
UCSCiuc021urw.2 human [A6NNF4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
730087

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF726
HGNCiHGNC:32462 ZNF726
neXtProtiNX_A6NNF4
OpenTargetsiENSG00000213967

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153236
HOGENOMiHOG000234617
InParanoidiA6NNF4
KOiK09228
OrthoDBi1318335at2759

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
730087

Protein Ontology

More...
PROi
PR:A6NNF4

Gene expression databases

BgeeiENSG00000213967 Expressed in 85 organ(s), highest expression level in lung
ExpressionAtlasiA6NNF4 baseline and differential

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN726_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NNF4
Secondary accession number(s): M0R0X8, Q86Y87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 14, 2014
Last modified: May 8, 2019
This is version 105 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again