UniProtKB - A6NNA5 (DRGX_HUMAN)
Protein
Dorsal root ganglia homeobox protein
Gene
DRGX
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 33 – 92 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- axon guidance Source: Ensembl
- detection of chemical stimulus Source: Ensembl
- detection of temperature stimulus Source: Ensembl
- dorsal spinal cord development Source: Ensembl
- neuron migration Source: Ensembl
- sensory perception of mechanical stimulus Source: Ensembl
- trigeminal nerve development Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Dorsal root ganglia homeobox proteinAlternative name(s): Paired-related homeobox protein-like 1 |
Gene namesi | Name:DRGX Synonyms:PRRXL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165606.8 |
HGNCi | HGNC:21536 DRGX |
MIMi | 606701 gene |
neXtProti | NX_A6NNA5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000165606 |
Polymorphism and mutation databases
BioMutai | DRGX |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000300814 | 1 – 263 | Dorsal root ganglia homeobox proteinAdd BLAST | 263 |
Proteomic databases
EPDi | A6NNA5 |
jPOSTi | A6NNA5 |
PaxDbi | A6NNA5 |
PRIDEi | A6NNA5 |
ProteomicsDBi | 1595 |
PTM databases
iPTMneti | A6NNA5 |
PhosphoSitePlusi | A6NNA5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165606 Expressed in 27 organ(s), highest expression level in C1 segment of cervical spinal cord |
Organism-specific databases
HPAi | HPA043978 |
Interactioni
Subunit structurei
Interacts with RGMB.By similarity
Protein-protein interaction databases
STRINGi | 9606.ENSP00000401653 |
Structurei
3D structure databases
ProteinModelPortali | A6NNA5 |
SMRi | A6NNA5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 204 – 217 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490 Eukaryota ENOG410YIJ3 LUCA |
GeneTreei | ENSGT00940000159008 |
HOGENOMi | HOG000231518 |
HOVERGENi | HBG106743 |
InParanoidi | A6NNA5 |
OMAi | KGSPLCS |
OrthoDBi | 1097815at2759 |
PhylomeDBi | A6NNA5 |
Family and domain databases
CDDi | cd00086 homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom |
Pfami | View protein in Pfam PF00046 Homeodomain, 1 hit PF03826 OAR, 1 hit |
SMARTi | View protein in SMART SM00389 HOX, 1 hit |
SUPFAMi | SSF46689 SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
A6NNA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFYFHCPPQL EGTATFGNHS SGDFDDGFLR RKQRRNRTTF TLQQLEALEA
60 70 80 90 100
VFAQTHYPDV FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP
110 120 130 140 150
GAKEPMAEVT PPPVRNINSP PPGDQARSKK EALEAQQSLG RTVGPAGPFF
160 170 180 190 200
PSCLPGTLLN TATYAQALSH VASLKGGPLC SCCVPDPMGL SFLPTYGCQS
210 220 230 240 250
NRTASVATLR MKAREHSEAV LQSANLLPST SSSPGPVAKP APPDGSQEKT
260
SPTKEQSEAE KSV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC027674 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93100.1 |
CCDSi | CCDS44388.2 |
RefSeqi | NP_001263380.1, NM_001276451.1 |
UniGenei | Hs.534530 |
Genome annotation databases
Ensembli | ENST00000374139; ENSP00000363254; ENSG00000165606 ENST00000434016; ENSP00000401653; ENSG00000165606 |
GeneIDi | 644168 |
KEGGi | hsa:644168 |
UCSCi | uc021pqd.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC027674 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93100.1 |
CCDSi | CCDS44388.2 |
RefSeqi | NP_001263380.1, NM_001276451.1 |
UniGenei | Hs.534530 |
3D structure databases
ProteinModelPortali | A6NNA5 |
SMRi | A6NNA5 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000401653 |
PTM databases
iPTMneti | A6NNA5 |
PhosphoSitePlusi | A6NNA5 |
Polymorphism and mutation databases
BioMutai | DRGX |
Proteomic databases
EPDi | A6NNA5 |
jPOSTi | A6NNA5 |
PaxDbi | A6NNA5 |
PRIDEi | A6NNA5 |
ProteomicsDBi | 1595 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000374139; ENSP00000363254; ENSG00000165606 ENST00000434016; ENSP00000401653; ENSG00000165606 |
GeneIDi | 644168 |
KEGGi | hsa:644168 |
UCSCi | uc021pqd.2 human |
Organism-specific databases
CTDi | 644168 |
EuPathDBi | HostDB:ENSG00000165606.8 |
GeneCardsi | DRGX |
HGNCi | HGNC:21536 DRGX |
HPAi | HPA043978 |
MIMi | 606701 gene |
neXtProti | NX_A6NNA5 |
OpenTargetsi | ENSG00000165606 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490 Eukaryota ENOG410YIJ3 LUCA |
GeneTreei | ENSGT00940000159008 |
HOGENOMi | HOG000231518 |
HOVERGENi | HBG106743 |
InParanoidi | A6NNA5 |
OMAi | KGSPLCS |
OrthoDBi | 1097815at2759 |
PhylomeDBi | A6NNA5 |
Miscellaneous databases
GenomeRNAii | 644168 |
PROi | PR:A6NNA5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165606 Expressed in 27 organ(s), highest expression level in C1 segment of cervical spinal cord |
Family and domain databases
CDDi | cd00086 homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom |
Pfami | View protein in Pfam PF00046 Homeodomain, 1 hit PF03826 OAR, 1 hit |
SMARTi | View protein in SMART SM00389 HOX, 1 hit |
SUPFAMi | SSF46689 SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | DRGX_HUMAN | |
Accessioni | A6NNA5Primary (citable) accession number: A6NNA5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 13, 2019 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot