Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative gap junction epsilon-1 protein

Gene

GJE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions.By similarity

Caution

Could be the product of a pseudogene. There is no mRNA or EST support for this sequence, and GJE1 is a pseudogene in most other primate species.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative gap junction epsilon-1 proteinCurated
Alternative name(s):
Connexin-23
Short name:
Cx23
Gene namesi
Name:GJE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000203733.5
HGNCiHGNC:33251 GJE1
neXtProtiNX_A6NN92

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 76ExtracellularSequence analysisAdd BLAST32
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 112CytoplasmicSequence analysisAdd BLAST15
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 170ExtracellularSequence analysisAdd BLAST37
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 205CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100126572
OpenTargetsiENSG00000203733

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176111 – 205Putative gap junction epsilon-1 proteinAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 161By similarity
Disulfide bondi64 ↔ 148By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6NN92
PRIDEiA6NN92
ProteomicsDBi1590

Expressioni

Tissue specificityi

Not detected in lens or retina.1 Publication

Organism-specific databases

HPAiHPA014916

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000455469

Structurei

3D structure databases

ProteinModelPortaliA6NN92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEBX Eukaryota
ENOG410Y93T LUCA
GeneTreeiENSGT00390000010547
HOVERGENiHBG094838
InParanoidiA6NN92
OMAiYAACKSI
OrthoDBiEOG091G0JO4
PhylomeDBiA6NN92

Family and domain databases

Gene3Di1.20.1440.80, 2 hits
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 2 hits
SMARTiView protein in SMART
SM01089 Connexin_CCC, 1 hit

Sequencei

Sequence statusi: Complete.

A6NN92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNYIKNFY EGCVKPPTVI GQFHTLFFGS IRIFFLGVLG FAVYGNEALH
60 70 80 90 100
FICDPDKREV NLFCYNQFRP ITPQVSFSAL QLVIVLVPGA LFHLYAACKS
110 120 130 140 150
INQECILQKP IYTIIYILSV LLRISLAAIA FWLQIYLFGF QVKSLYLCDA
160 170 180 190 200
RSLGENMIIR CMVPEHFEKT IFLIAINTFT TITILLFVAE IFEIIFRRLY

FPFRQ
Length:205
Mass (Da):23,755
Last modified:July 24, 2007 - v1
Checksum:i494389B01BCB07D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL033522 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000450456; ENSP00000455469; ENSG00000203733
UCSCiuc063rxt.1 human

Similar proteinsi

Entry informationi

Entry nameiCXE1_HUMAN
AccessioniPrimary (citable) accession number: A6NN92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health