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Protein

Collagen alpha-6(VI) chain

Gene

COL6A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Collagen VI acts as a cell-binding protein.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8948216 Collagen chain trimerization

SIGNOR Signaling Network Open Resource

More...
SIGNORi
A6NMZ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-6(VI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL6A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000206384.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27023 COL6A6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616613 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NMZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000206384

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165697087

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL6A6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500026630620 – 2263Collagen alpha-6(VI) chainAdd BLAST2244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi198N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi288N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi930N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi988N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1290N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NMZ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NMZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NMZ7

PRoteomics IDEntifications database

More...
PRIDEi
A6NMZ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1573
1574 [A6NMZ7-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1140

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NMZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NMZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206384 Expressed in 97 organ(s), highest expression level in parietal pleura

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NMZ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NMZ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045239

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI).Curated

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NMZ7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NMZ7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 206VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini229 – 411VWFA 2PROSITE-ProRule annotationAdd BLAST183
Domaini436 – 606VWFA 3PROSITE-ProRule annotationAdd BLAST171
Domaini622 – 791VWFA 4PROSITE-ProRule annotationAdd BLAST170
Domaini809 – 982VWFA 5PROSITE-ProRule annotationAdd BLAST174
Domaini1000 – 1171VWFA 6PROSITE-ProRule annotationAdd BLAST172
Domaini1187 – 1371VWFA 7PROSITE-ProRule annotationAdd BLAST185
Domaini1757 – 1937VWFA 8PROSITE-ProRule annotationAdd BLAST181
Domaini1965 – 2166VWFA 9PROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 1391Nonhelical regionAdd BLAST1372
Regioni1392 – 1725Triple-helical regionAdd BLAST334
Regioni1726 – 2263Nonhelical regionAdd BLAST538

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1508 – 1510Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410Y0KT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111864

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107743

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A6NMZ7

KEGG Orthology (KO)

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KOi
K06238

Identification of Orthologs from Complete Genome Data

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OMAi
ATDFQEM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G006Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NMZ7

TreeFam database of animal gene trees

More...
TreeFami
TF318242

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 8 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 1 hit
PF00092 VWA, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327 VWA, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NMZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLLILFLVI ICSHISVNQD SGPEYADVVF LVDSSDRLGS KSFPFVKMFI
60 70 80 90 100
TKMISSLPIE ADKYRVALAQ YSDKLHSEFH LSTFKGRSPM LNHLRKNFGF
110 120 130 140 150
IGGSLQIGKA LQEAHRTYFS APANGRDKKQ FPPILVVLAS SESEDNVEEA
160 170 180 190 200
SKALRKDGVK IISVGVQKAS EENLKAMATS QFHFNLRTVR DLSMFSQNMT
210 220 230 240 250
HIIKDVIKYK EGAVDDIFVE ACQGPSMADV VFLLDMSING SEENFDYLKG
260 270 280 290 300
FLEESVSALD IKENCMRVGL VAYSNETKVI NSLSMGINKS EVLQHIQNLS
310 320 330 340 350
PRTGKAYTGA AIKKLRKEVF SARNGSRKNQ GVPQIAVLVT HRDSEDNVTK
360 370 380 390 400
AAVNLRREGV TIFTLGIEGA SDTQLEKIAS HPAEQYVSKL KTFADLAAHN
410 420 430 440 450
QTFLKKLRNQ ITHTVSVFSE RTETLKSGCV DTEEADIYLL IDGSGSTQAT
460 470 480 490 500
DFHEMKTFLS EVVGMFNIAP HKVRVGAVQY ADSWDLEFEI NKYSNKQDLG
510 520 530 540 550
KAIENIRQMG GNTNTGAALN FTLSLLQKAK KQRGNKVPCH LVVLTNGMSK
560 570 580 590 600
DSILEPANRL REEHIRVYAI GIKEANQTQL REIAGEEKRV YYVHDFDALK
610 620 630 640 650
DIRNQVVQEI CTEEACKEMK ADIMFLVDSS GSIGPENFSK MKTFMKNLVS
660 670 680 690 700
KSQIGPDRVQ IGVVQFSDIN KEEFQLNRFM SQSDISNAID QMAHIGQTTL
710 720 730 740 750
TGSALSFVSQ YFSPTKGARP NIRKFLILIT DGEAQDIVKE PAVVLRQEGV
760 770 780 790 800
IIYSVGVFGS NVTQLEEISG RPEMVFYVEN FDILQRIEDD LVFGICSPRE
810 820 830 840 850
ECKRIEVLDV VFVIDSSGSI DYDEYNIMKD FMIGLVKKAD VGKNQVRFGA
860 870 880 890 900
LKYADDPEVL FYLDDFGTKL EVISVLQNDQ AMGGSTYTAE ALGFSDHMFT
910 920 930 940 950
EARGSRLNKG VPQVLIVITD GESHDADKLN ATAKALRDKG ILVLAVGIDG
960 970 980 990 1000
ANPVELLAMA GSSDKYFFVE TFGGLKGIFS DVTASVCNSS KVDCEIDKVD
1010 1020 1030 1040 1050
LVFLMDGSTS IQPNDFKKMK EFLASVVQDF DVSLNRVRIG AAQFSDTYHP
1060 1070 1080 1090 1100
EFPLGTFIGE KEISFQIENI KQIFGNTHIG AALREVEHYF RPDMGSRINT
1110 1120 1130 1140 1150
GTPQVLLVLT DGQSQDEVAQ AAEALRHRGI DIYSVGIGDV DDQQLIQITG
1160 1170 1180 1190 1200
TAEKKLTVHN FDELKKVNKR IVRNICTTAG ESNCFVDVVV GFDVSTQEKG
1210 1220 1230 1240 1250
QTLLEGQPWM ETYLQDILRA ISSLNGVSCE VGTETQVSVA FQVTNAMEKY
1260 1270 1280 1290 1300
SPKFEIYSEN ILNSLKDITV KGPSLLNANL LDSLWDTFQN KSAARGKVVL
1310 1320 1330 1340 1350
LFSDGLDDDV EKLEQKSDEL RKEGLNALIT VALDGPADSS DLADLPYIEF
1360 1370 1380 1390 1400
GKGFEYRTQL SIGMRELGSR LSKQLVNVAE RTCCCLFCKC IGGDGTMGDP
1410 1420 1430 1440 1450
GPPGKRGPPG FKGSEGYLGE EGIAGERGAP GPVGEQGTKG CYGTKGPKGN
1460 1470 1480 1490 1500
RGLNGQEGEV GENGIDGLNG EQGDNGLPGR KGEKGDEGSQ GSPGKRGTPG
1510 1520 1530 1540 1550
DRGAKGLRGD PGAPGVDSSI EGPTGLKGER GRQGRRGWPG PPGTPGSRRK
1560 1570 1580 1590 1600
TAAHGRRGHT GPQGTAGIPG PDGLEGSLGL KGPQGPRGEA GVKGEKGGVG
1610 1620 1630 1640 1650
SKGPQGPPGP GGEAGNQGRL GSQGNKGEPG DLGEKGAVGF PGPRGLQGND
1660 1670 1680 1690 1700
GSPGYGSVGR KGAKGQEGFP GESGPKGEIG DPGGPGETGL KGARGKMISA
1710 1720 1730 1740 1750
GLPGEMGSPG EPGPPGRKGV KGAKGLASFS TCELIQYVRD RSPGRHGKPE
1760 1770 1780 1790 1800
CPVHPTELVF ALDHSRDVTE QEFERMKEMM AFLVRDIKVR ENSCPVGAHI
1810 1820 1830 1840 1850
AILSYNSHAR HLVRFSDAYK KSQLLREIET IPYERSSASR EIGRAMRFIS
1860 1870 1880 1890 1900
RNVFKRTLPG AHTRKIATFF SSGQSADAHS ITTAAMEFGA LEIIPVVITF
1910 1920 1930 1940 1950
SNVPSVRRAF AIDDTGTFQV IVVPSGADYI PALERLQRCT FCYDVCKPDA
1960 1970 1980 1990 2000
SCDQARPPPV QSYMDAAFLL DASRNMGSAE FEDIRAFLGA LLDHFEITPE
2010 2020 2030 2040 2050
PETSVTGDRV ALLSHAPPDF LPNTQKSPVR AEFNLTTYRS KRLMKRHVHE
2060 2070 2080 2090 2100
SVKQLNGDAF IGHALQWTLD NVFLSTPNLR RNKVIFVISA GETSHLDGEI
2110 2120 2130 2140 2150
LKKESLRAKC QGYALFVFSL GPIWDDKELE DLASHPLDHH LVQLGRIHKP
2160 2170 2180 2190 2200
DHSYGVKFVK SFINSIRRAI NKYPPINLKI KCNRLNSIDP KQPPRPFRSF
2210 2220 2230 2240 2250
VPGPLKATLK EDVLQKAKFF QDKKYLSRVA RSGRDDAIQN FMRSTSHTFK
2260
NGRMIESAPK QHD
Length:2,263
Mass (Da):247,173
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEED4F30ABAED7F30
GO
Isoform 2 (identifier: A6NMZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1512-1520: GAPGVDSSI → VSARAANWS
     1521-2263: Missing.

Note: No experimental confirmation available.
Show »
Length:1,520
Mass (Da):166,865
Checksum:i227C6A3808F5FA5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA33H0YA33_HUMAN
Collagen alpha-6(VI) chain
COL6A6
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y940H0Y940_HUMAN
Collagen alpha-6(VI) chain
COL6A6
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1429A → V in CAH10639 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043609345E → K. Corresponds to variant dbSNP:rs4613427Ensembl.1
Natural variantiVAR_043610370A → T. Corresponds to variant dbSNP:rs9830253Ensembl.1
Natural variantiVAR_043611461E → A. Corresponds to variant dbSNP:rs11921769Ensembl.1
Natural variantiVAR_061120556P → S. Corresponds to variant dbSNP:rs59021909Ensembl.1
Natural variantiVAR_0436121739R → Q. Corresponds to variant dbSNP:rs16830494Ensembl.1
Natural variantiVAR_0436131799H → R. Corresponds to variant dbSNP:rs7614116Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0339141512 – 1520GAPGVDSSI → VSARAANWS in isoform 2. 1 Publication9
Alternative sequenceiVSP_0339151521 – 2263Missing in isoform 2. 1 PublicationAdd BLAST743

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AM774225 mRNA Translation: CAO81741.1
AM774226 mRNA Translation: CAO81739.1
AM774227 mRNA Translation: CAO81740.1
AC093006 Genomic DNA No translation available.
AC128683 Genomic DNA No translation available.
AL713792 mRNA Translation: CAH10639.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS46911.1 [A6NMZ7-1]

NCBI Reference Sequences

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RefSeqi
NP_001096078.1, NM_001102608.1 [A6NMZ7-1]
XP_005247178.1, XM_005247121.4 [A6NMZ7-1]
XP_011510727.1, XM_011512425.2 [A6NMZ7-1]
XP_011510728.1, XM_011512426.2 [A6NMZ7-1]
XP_011510730.1, XM_011512428.2 [A6NMZ7-1]
XP_016861200.1, XM_017005711.1 [A6NMZ7-1]
XP_016861201.1, XM_017005712.1 [A6NMZ7-1]
XP_016861202.1, XM_017005713.1 [A6NMZ7-1]
XP_016861203.1, XM_017005714.1 [A6NMZ7-1]
XP_016861204.1, XM_017005715.1 [A6NMZ7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591282
Hs.596709
Hs.596805

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358511; ENSP00000351310; ENSG00000206384 [A6NMZ7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
131873

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:131873

UCSC genome browser

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UCSCi
uc010htl.4 human [A6NMZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774225 mRNA Translation: CAO81741.1
AM774226 mRNA Translation: CAO81739.1
AM774227 mRNA Translation: CAO81740.1
AC093006 Genomic DNA No translation available.
AC128683 Genomic DNA No translation available.
AL713792 mRNA Translation: CAH10639.2
CCDSiCCDS46911.1 [A6NMZ7-1]
RefSeqiNP_001096078.1, NM_001102608.1 [A6NMZ7-1]
XP_005247178.1, XM_005247121.4 [A6NMZ7-1]
XP_011510727.1, XM_011512425.2 [A6NMZ7-1]
XP_011510728.1, XM_011512426.2 [A6NMZ7-1]
XP_011510730.1, XM_011512428.2 [A6NMZ7-1]
XP_016861200.1, XM_017005711.1 [A6NMZ7-1]
XP_016861201.1, XM_017005712.1 [A6NMZ7-1]
XP_016861202.1, XM_017005713.1 [A6NMZ7-1]
XP_016861203.1, XM_017005714.1 [A6NMZ7-1]
XP_016861204.1, XM_017005715.1 [A6NMZ7-1]
UniGeneiHs.591282
Hs.596709
Hs.596805

3D structure databases

ProteinModelPortaliA6NMZ7
SMRiA6NMZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351310

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

GlyConnecti1140
iPTMnetiA6NMZ7
PhosphoSitePlusiA6NMZ7

Polymorphism and mutation databases

BioMutaiCOL6A6

Proteomic databases

EPDiA6NMZ7
MaxQBiA6NMZ7
PaxDbiA6NMZ7
PRIDEiA6NMZ7
ProteomicsDBi1573
1574 [A6NMZ7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358511; ENSP00000351310; ENSG00000206384 [A6NMZ7-1]
GeneIDi131873
KEGGihsa:131873
UCSCiuc010htl.4 human [A6NMZ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
131873
EuPathDBiHostDB:ENSG00000206384.10

GeneCards: human genes, protein and diseases

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GeneCardsi
COL6A6

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0003677
HGNCiHGNC:27023 COL6A6
HPAiHPA045239
MIMi616613 gene
neXtProtiNX_A6NMZ7
OpenTargetsiENSG00000206384
PharmGKBiPA165697087

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410Y0KT LUCA
GeneTreeiENSGT00940000155619
HOGENOMiHOG000111864
HOVERGENiHBG107743
InParanoidiA6NMZ7
KOiK06238
OMAiATDFQEM
OrthoDBiEOG091G006Y
PhylomeDBiA6NMZ7
TreeFamiTF318242

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8948216 Collagen chain trimerization
SIGNORiA6NMZ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COL6A6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
131873

Protein Ontology

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PROi
PR:A6NMZ7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000206384 Expressed in 97 organ(s), highest expression level in parietal pleura
ExpressionAtlasiA6NMZ7 baseline and differential
GenevisibleiA6NMZ7 HS

Family and domain databases

Gene3Di3.40.50.410, 8 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00092 VWA, 8 hits
SMARTiView protein in SMART
SM00327 VWA, 9 hits
SUPFAMiSSF53300 SSF53300, 9 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO6A6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NMZ7
Secondary accession number(s): A7DZQ0
, A7DZQ1, A7DZQ2, Q69YT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 5, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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