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Protein

Eukaryotic translation initiation factor 4E type 1B

Gene

EIF4E1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 1B
Gene namesi
Name:EIF4E1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000175766.11
HGNCiHGNC:33179 EIF4E1B
neXtProtiNX_A6NMX2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175766
PharmGKBiPA162384974

Polymorphism and mutation databases

BioMutaiEIF4E1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425131 – 242Eukaryotic translation initiation factor 4E type 1BAdd BLAST242

Proteomic databases

EPDiA6NMX2
MaxQBiA6NMX2
PaxDbiA6NMX2
PRIDEiA6NMX2
ProteomicsDBi1567

PTM databases

iPTMnetiA6NMX2
PhosphoSitePlusiA6NMX2

Expressioni

Gene expression databases

BgeeiENSG00000175766 Expressed in 38 organ(s), highest expression level in prefrontal cortex
CleanExiHS_EIF4E1B
ExpressionAtlasiA6NMX2 baseline and differential

Organism-specific databases

HPAiHPA045045

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E AND EIF4G (By similarity).By similarity

Protein-protein interaction databases

IntActiA6NMX2, 1 interactor
STRINGi9606.ENSP00000323714

Structurei

3D structure databases

ProteinModelPortaliA6NMX2
SMRiA6NMX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 65EIF4EBP1/2/3 bindingBy similarity4
Regioni81 – 827-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni98 – 102EIF4EBP1/2/3 bindingBy similarity5
Regioni127 – 1287-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni157 – 164EIF4EBP1/2/3 bindingBy similarity8
Regioni182 – 1877-methylguanosine-containing mRNA cap bindingBy similarity6
Regioni230 – 2327-methylguanosine-containing mRNA cap bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1670 Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000186751
HOVERGENiHBG006130
InParanoidiA6NMX2
KOiK03259
OMAiNKFGGRW
OrthoDBiEOG091G0IVA
PhylomeDBiA6NMX2
TreeFamiTF101526

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NMX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAVEVSEAE GGIREWEEEE KEEEAAERTP TGEKSPNSPR TLLSLRGKAR
60 70 80 90 100
TGGPMEVKLE LHPLQNRWAL WFFKNDRSRA WQDNLHLVTK VDTVEDFWAL
110 120 130 140 150
YSHIQLASKL SSGCDYALFK DGIQPMWEDS RNKRGGRWLV SLAKQQRHIE
160 170 180 190 200
LDRLWLETLL CLIGESFEEH SREVCGAVVN IRTKGDKIAV WTREAENQAG
210 220 230 240
VLHVGRVYKE RLGLSPKTII GYQAHADTAT KSNSLAKNKF VV
Length:242
Mass (Da):27,596
Last modified:July 1, 2008 - v3
Checksum:iC441D5F0A082339D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8X3H0Y8X3_HUMAN
Eukaryotic translation initiation f...
EIF4E1B
171Annotation score:
D6RHE2D6RHE2_HUMAN
Eukaryotic translation initiation f...
EIF4E1B
90Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044209227D → Y. Corresponds to variant dbSNP:rs13163938Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091934 Genomic DNA No translation available.
CCDSiCCDS47345.1
RefSeqiNP_001092878.1, NM_001099408.1
XP_011532801.1, XM_011534499.2
UniGeneiHs.448362

Genome annotation databases

EnsembliENST00000318682; ENSP00000323714; ENSG00000175766
ENST00000504597; ENSP00000427633; ENSG00000175766
GeneIDi253314
KEGGihsa:253314
UCSCiuc010jkf.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091934 Genomic DNA No translation available.
CCDSiCCDS47345.1
RefSeqiNP_001092878.1, NM_001099408.1
XP_011532801.1, XM_011534499.2
UniGeneiHs.448362

3D structure databases

ProteinModelPortaliA6NMX2
SMRiA6NMX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NMX2, 1 interactor
STRINGi9606.ENSP00000323714

PTM databases

iPTMnetiA6NMX2
PhosphoSitePlusiA6NMX2

Polymorphism and mutation databases

BioMutaiEIF4E1B

Proteomic databases

EPDiA6NMX2
MaxQBiA6NMX2
PaxDbiA6NMX2
PRIDEiA6NMX2
ProteomicsDBi1567

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318682; ENSP00000323714; ENSG00000175766
ENST00000504597; ENSP00000427633; ENSG00000175766
GeneIDi253314
KEGGihsa:253314
UCSCiuc010jkf.1 human

Organism-specific databases

CTDi253314
EuPathDBiHostDB:ENSG00000175766.11
GeneCardsiEIF4E1B
HGNCiHGNC:33179 EIF4E1B
HPAiHPA045045
neXtProtiNX_A6NMX2
OpenTargetsiENSG00000175766
PharmGKBiPA162384974
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1670 Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000186751
HOVERGENiHBG006130
InParanoidiA6NMX2
KOiK03259
OMAiNKFGGRW
OrthoDBiEOG091G0IVA
PhylomeDBiA6NMX2
TreeFamiTF101526

Miscellaneous databases

GenomeRNAii253314
PROiPR:A6NMX2

Gene expression databases

BgeeiENSG00000175766 Expressed in 38 organ(s), highest expression level in prefrontal cortex
CleanExiHS_EIF4E1B
ExpressionAtlasiA6NMX2 baseline and differential

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI4E1B_HUMAN
AccessioniPrimary (citable) accession number: A6NMX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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