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Entry version 95 (12 Aug 2020)
Sequence version 3 (01 Jul 2008)
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Protein

Eukaryotic translation initiation factor 4E type 1B

Gene

EIF4E1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A6NMX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4E1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175766.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33179, EIF4E1B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NMX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
253314

Open Targets

More...
OpenTargetsi
ENSG00000175766

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162384974

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A6NMX2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4E1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003425131 – 242Eukaryotic translation initiation factor 4E type 1BAdd BLAST242

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A6NMX2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NMX2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NMX2

PeptideAtlas

More...
PeptideAtlasi
A6NMX2

PRoteomics IDEntifications database

More...
PRIDEi
A6NMX2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1567

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NMX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NMX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175766, Expressed in prefrontal cortex and 49 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NMX2, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175766, Group enriched (brain, epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E AND EIF4G (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A6NMX2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323714

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A6NMX2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NMX2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni62 – 65EIF4EBP1/2/3 bindingBy similarity4
Regioni81 – 827-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni98 – 102EIF4EBP1/2/3 bindingBy similarity5
Regioni127 – 1287-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni157 – 164EIF4EBP1/2/3 bindingBy similarity8
Regioni182 – 1877-methylguanosine-containing mRNA cap bindingBy similarity6
Regioni230 – 2327-methylguanosine-containing mRNA cap bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1670, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_043552_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NMX2

KEGG Orthology (KO)

More...
KOi
K03259

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPLENTW

Database of Orthologous Groups

More...
OrthoDBi
1394271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NMX2

TreeFam database of animal gene trees

More...
TreeFami
TF101526

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023398, TIF_eIF4e-like
IPR001040, TIF_eIF_4E
IPR019770, TIF_eIF_4E_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11960, PTHR11960, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01652, IF4E, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55418, SSF55418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00813, IF4E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NMX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAVEVSEAE GGIREWEEEE KEEEAAERTP TGEKSPNSPR TLLSLRGKAR
60 70 80 90 100
TGGPMEVKLE LHPLQNRWAL WFFKNDRSRA WQDNLHLVTK VDTVEDFWAL
110 120 130 140 150
YSHIQLASKL SSGCDYALFK DGIQPMWEDS RNKRGGRWLV SLAKQQRHIE
160 170 180 190 200
LDRLWLETLL CLIGESFEEH SREVCGAVVN IRTKGDKIAV WTREAENQAG
210 220 230 240
VLHVGRVYKE RLGLSPKTII GYQAHADTAT KSNSLAKNKF VV
Length:242
Mass (Da):27,596
Last modified:July 1, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC441D5F0A082339D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8X3H0Y8X3_HUMAN
Eukaryotic translation initiation f...
EIF4E1B
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE2D6RHE2_HUMAN
Eukaryotic translation initiation f...
EIF4E1B
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044209227D → Y. Corresponds to variant dbSNP:rs13163938Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC091934 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47345.1

NCBI Reference Sequences

More...
RefSeqi
NP_001092878.1, NM_001099408.1
XP_011532801.1, XM_011534499.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318682; ENSP00000323714; ENSG00000175766
ENST00000504597; ENSP00000427633; ENSG00000175766
ENST00000647833; ENSP00000497422; ENSG00000175766

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
253314

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:253314

UCSC genome browser

More...
UCSCi
uc010jkf.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091934 Genomic DNA No translation available.
CCDSiCCDS47345.1
RefSeqiNP_001092878.1, NM_001099408.1
XP_011532801.1, XM_011534499.2

3D structure databases

SMRiA6NMX2
ModBaseiSearch...

Protein-protein interaction databases

IntActiA6NMX2, 1 interactor
STRINGi9606.ENSP00000323714

PTM databases

iPTMnetiA6NMX2
PhosphoSitePlusiA6NMX2

Polymorphism and mutation databases

BioMutaiEIF4E1B

Proteomic databases

MassIVEiA6NMX2
MaxQBiA6NMX2
PaxDbiA6NMX2
PeptideAtlasiA6NMX2
PRIDEiA6NMX2
ProteomicsDBi1567

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63751, 28 antibodies

Genome annotation databases

EnsembliENST00000318682; ENSP00000323714; ENSG00000175766
ENST00000504597; ENSP00000427633; ENSG00000175766
ENST00000647833; ENSP00000497422; ENSG00000175766
GeneIDi253314
KEGGihsa:253314
UCSCiuc010jkf.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
253314
DisGeNETi253314
EuPathDBiHostDB:ENSG00000175766.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF4E1B
HGNCiHGNC:33179, EIF4E1B
HPAiENSG00000175766, Group enriched (brain, epididymis)
neXtProtiNX_A6NMX2
OpenTargetsiENSG00000175766
PharmGKBiPA162384974

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1670, Eukaryota
GeneTreeiENSGT00940000160838
HOGENOMiCLU_043552_1_1_1
InParanoidiA6NMX2
KOiK03259
OMAiHPLENTW
OrthoDBi1394271at2759
PhylomeDBiA6NMX2
TreeFamiTF101526

Enzyme and pathway databases

PathwayCommonsiA6NMX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
253314, 4 hits in 871 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
253314
PharosiA6NMX2, Tdark

Protein Ontology

More...
PROi
PR:A6NMX2
RNActiA6NMX2, protein

Gene expression databases

BgeeiENSG00000175766, Expressed in prefrontal cortex and 49 other tissues
ExpressionAtlasiA6NMX2, baseline and differential

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398, TIF_eIF4e-like
IPR001040, TIF_eIF_4E
IPR019770, TIF_eIF_4E_CS
PANTHERiPTHR11960, PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652, IF4E, 1 hit
SUPFAMiSSF55418, SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813, IF4E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI4E1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NMX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: August 12, 2020
This is version 95 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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