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Protein

Homeobox protein DBX1

Gene

DBX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 240HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:DBX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000109851.6
HGNCiHGNC:33185 DBX1
neXtProtiNX_A6NMT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi120237
OpenTargetsiENSG00000109851

Polymorphism and mutation databases

BioMutaiDBX1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028431 – 343Homeobox protein DBX1Add BLAST343

Proteomic databases

PRIDEiA6NMT0
ProteomicsDBi1559

PTM databases

iPTMnetiA6NMT0
PhosphoSitePlusiA6NMT0

Expressioni

Gene expression databases

BgeeiENSG00000109851 Expressed in 3 organ(s), highest expression level in right testis
CleanExiHS_DBX1

Organism-specific databases

HPAiHPA039802

Structurei

3D structure databases

ProteinModelPortaliA6NMT0
SMRiA6NMT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 280Poly-Glu5
Compositional biasi329 – 339Poly-GluAdd BLAST11

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00910000143996
HOVERGENiHBG005454
InParanoidiA6NMT0
OMAiMMFPSLI
OrthoDBiEOG091G0MGV
PhylomeDBiA6NMT0

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NMT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PAYLPRSVPT ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS
110 120 130 140 150
PASETTFLKF GVNAILSSGP RTETSPALLQ SVPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKMF
210 220 230 240 250
QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL
310 320 330 340
RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS
Length:343
Mass (Da):37,283
Last modified:September 11, 2007 - v2
Checksum:iE5C4EB73331E7B69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068860 Genomic DNA No translation available.
CCDSiCCDS31443.2
RefSeqiNP_001025036.2, NM_001029865.2

Genome annotation databases

EnsembliENST00000524983; ENSP00000436881; ENSG00000109851
GeneIDi120237
KEGGihsa:120237
UCSCiuc021qey.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068860 Genomic DNA No translation available.
CCDSiCCDS31443.2
RefSeqiNP_001025036.2, NM_001029865.2

3D structure databases

ProteinModelPortaliA6NMT0
SMRiA6NMT0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NMT0
PhosphoSitePlusiA6NMT0

Polymorphism and mutation databases

BioMutaiDBX1

Proteomic databases

PRIDEiA6NMT0
ProteomicsDBi1559

Protocols and materials databases

DNASUi120237
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524983; ENSP00000436881; ENSG00000109851
GeneIDi120237
KEGGihsa:120237
UCSCiuc021qey.2 human

Organism-specific databases

CTDi120237
DisGeNETi120237
EuPathDBiHostDB:ENSG00000109851.6
GeneCardsiDBX1
HGNCiHGNC:33185 DBX1
HPAiHPA039802
neXtProtiNX_A6NMT0
OpenTargetsiENSG00000109851
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00910000143996
HOVERGENiHBG005454
InParanoidiA6NMT0
OMAiMMFPSLI
OrthoDBiEOG091G0MGV
PhylomeDBiA6NMT0

Miscellaneous databases

GeneWikiiDBX1
GenomeRNAii120237
PROiPR:A6NMT0

Gene expression databases

BgeeiENSG00000109851 Expressed in 3 organ(s), highest expression level in right testis
CleanExiHS_DBX1

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDBX1_HUMAN
AccessioniPrimary (citable) accession number: A6NMT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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