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Protein

Leucine-rich repeat-containing protein 37A

Gene

LRRC37A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC37A
Synonyms:LRRC37A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000176681.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29069 LRRC37A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616555 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NMS7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 1582ExtracellularSequence analysisAdd BLAST1547
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1583 – 1603HelicalSequence analysisAdd BLAST21
Topological domaini1604 – 1700CytoplasmicSequence analysisAdd BLAST97

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9884

Open Targets

More...
OpenTargetsi
ENSG00000176681

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC37A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033707936 – 1700Leucine-rich repeat-containing protein 37AAdd BLAST1665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NMS7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NMS7

PRoteomics IDEntifications database

More...
PRIDEi
A6NMS7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1558

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NMS7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NMS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176681 Expressed in 85 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_LRRC37A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NMS7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NMS7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042121
HPA042701
HPA043056
HPA045090
HPA049080

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A6NMS7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326324

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NMS7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati866 – 887LRR 1Add BLAST22
Repeati890 – 911LRR 2Add BLAST22
Repeati914 – 935LRR 3Add BLAST22
Repeati938 – 959LRR 4Add BLAST22
Repeati965 – 986LRR 5Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRC37A family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJNR Eukaryota
ENOG410YV94 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113269

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NMS7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PINQEGT

Database of Orthologous Groups

More...
OrthoDBi
181606at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NMS7

TreeFam database of animal gene trees

More...
TreeFami
TF341959

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR015753 LRRC37
IPR032754 LRRC37_N
IPR029423 LRRC37AB_C

The PANTHER Classification System

More...
PANTHERi
PTHR23045 PTHR23045, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit
PF15779 LRRC37, 7 hits
PF14914 LRRC37AB_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A6NMS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT
60 70 80 90 100
SNPLGPPESW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ
110 120 130 140 150
ESTENLVPFL DTWDSAGEQP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL
160 170 180 190 200
KKDPAQRWSL AEIIGITRQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR
210 220 230 240 250
VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL
260 270 280 290 300
EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
310 320 330 340 350
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP
360 370 380 390 400
MEHELSISEQ QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH
410 420 430 440 450
QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE
460 470 480 490 500
PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA
510 520 530 540 550
EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG
560 570 580 590 600
FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
610 620 630 640 650
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ
660 670 680 690 700
VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL
710 720 730 740 750
PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQPPD
760 770 780 790 800
LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA
810 820 830 840 850
QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ
860 870 880 890 900
RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
910 920 930 940 950
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT
960 970 980 990 1000
ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV
1010 1020 1030 1040 1050
PLTTLKNILM MTVELEKLIL PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC
1060 1070 1080 1090 1100
LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIVEPE EPSDSSGINL
1110 1120 1130 1140 1150
SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS
1160 1170 1180 1190 1200
LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
1210 1220 1230 1240 1250
AEEKRLTSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP
1260 1270 1280 1290 1300
FSKGTPSTSS PAKALPQVRD RSKDLTHAIS ILESAKARVT NTKTSKPIVH
1310 1320 1330 1340 1350
ARKKYRFHKT RSHVTHRTTK VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL
1360 1370 1380 1390 1400
INSPSQGAFS SLGDLSPQEN PFLEVSALSE HFIEKNNTKH TTARNAFEEN
1410 1420 1430 1440 1450
DFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV
1460 1470 1480 1490 1500
GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
1510 1520 1530 1540 1550
LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN
1560 1570 1580 1590 1600
YINESTEAQS EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC
1610 1620 1630 1640 1650
LIVICCHRRS LQEDEEGFSR GIFRFLPWRG CSSRRESQDG LSSFGQPLWF
1660 1670 1680 1690 1700
KDLYKPLSAT RINNHAWKLH KKSSNEDKIL NRDPGDSEAP TEEEESEALP
Length:1,700
Mass (Da):188,258
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5DBA6389568D792
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUI5A8MUI5_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A
1,635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRB3A0A0G2JRB3_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A
1,635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNC9A0A0G2JNC9_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A
1,700Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP10E9PP10_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A
738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQV0A0A0G2JQV0_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A
738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH18088 differs from that shown. Reason: Frameshift at positions 8 and 177.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58E → D in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti58E → D in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti349P → S in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti349P → S in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti370P → S in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti370P → S in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti377P → L in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti377P → L in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti406A → D in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti406A → D in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti440T → A in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti440T → A in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti552T → I in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti558K → M in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti558K → M in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti630P → A in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti630P → A in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti776R → H in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti776R → H in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti785R → Q in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti785R → Q in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti1255T → A in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti1255T → A in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti1288R → G in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti1384E → G in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti1693E → G in AAH40501 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749232 mRNA Translation: CAH18088.1 Frameshift.
AC005829 Genomic DNA No translation available.
AC139026 Genomic DNA No translation available.
BC040501 mRNA Translation: AAH40501.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11504.2

NCBI Reference Sequences

More...
RefSeqi
NP_055649.4, NM_014834.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.579108
Hs.744157
Hs.744758

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320254; ENSP00000326324; ENSG00000176681

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9884

UCSC genome browser

More...
UCSCi
uc002ikg.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749232 mRNA Translation: CAH18088.1 Frameshift.
AC005829 Genomic DNA No translation available.
AC139026 Genomic DNA No translation available.
BC040501 mRNA Translation: AAH40501.2
CCDSiCCDS11504.2
RefSeqiNP_055649.4, NM_014834.4
UniGeneiHs.579108
Hs.744157
Hs.744758

3D structure databases

ProteinModelPortaliA6NMS7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NMS7, 1 interactor
STRINGi9606.ENSP00000326324

PTM databases

iPTMnetiA6NMS7
PhosphoSitePlusiA6NMS7

Polymorphism and mutation databases

BioMutaiLRRC37A

Proteomic databases

jPOSTiA6NMS7
PaxDbiA6NMS7
PRIDEiA6NMS7
ProteomicsDBi1558

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320254; ENSP00000326324; ENSG00000176681
GeneIDi9884
KEGGihsa:9884
UCSCiuc002ikg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9884
DisGeNETi9884
EuPathDBiHostDB:ENSG00000176681.14

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRC37A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013912
HIX0027330
HIX0039350
HIX0173525
HIX0173724
HIX0174144
HIX0174145
HIX0174159
HIX0202473
HGNCiHGNC:29069 LRRC37A
HPAiHPA042121
HPA042701
HPA043056
HPA045090
HPA049080
MIMi616555 gene
neXtProtiNX_A6NMS7
OpenTargetsiENSG00000176681

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJNR Eukaryota
ENOG410YV94 LUCA
GeneTreeiENSGT00530000063282
HOGENOMiHOG000113269
HOVERGENiHBG100009
InParanoidiA6NMS7
OMAiPINQEGT
OrthoDBi181606at2759
PhylomeDBiA6NMS7
TreeFamiTF341959

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRC37A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LRRC37A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9884

Protein Ontology

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PROi
PR:A6NMS7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176681 Expressed in 85 organ(s), highest expression level in testis
CleanExiHS_LRRC37A
ExpressionAtlasiA6NMS7 baseline and differential
GenevisibleiA6NMS7 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR015753 LRRC37
IPR032754 LRRC37_N
IPR029423 LRRC37AB_C
PANTHERiPTHR23045 PTHR23045, 2 hits
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF15779 LRRC37, 7 hits
PF14914 LRRC37AB_C, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL37A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NMS7
Secondary accession number(s): Q68DY2, Q8IWC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 31, 2011
Last modified: January 16, 2019
This is version 99 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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