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Protein

Protein FAM170B

Gene

FAM170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in fertilization through the acrosome reaction.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM170BCurated
Alternative name(s):
Acrosome-related protein1 Publication
Gene namesi
Name:FAM170BImported
Synonyms:C10orf73Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000172538.6
HGNCiHGNC:19736 FAM170B
neXtProtiNX_A6NMN3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387168

Polymorphism and mutation databases

BioMutaiFAM170B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104941 – 283Protein FAM170BAdd BLAST283

Proteomic databases

PaxDbiA6NMN3
PRIDEiA6NMN3
ProteomicsDBi1549
TopDownProteomicsiA6NMN3

PTM databases

iPTMnetiA6NMN3
PhosphoSitePlusiA6NMN3

Expressioni

Tissue specificityi

Exclusively expressed in adult testis.1 Publication

Gene expression databases

BgeeiENSG00000172538 Expressed in 9 organ(s), highest expression level in testis
CleanExiHS_FAM170B
GenevisibleiA6NMN3 HS

Organism-specific databases

HPAiHPA043899
HPA050610

Interactioni

Subunit structurei

Interacts with GOPC.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000308292

Structurei

3D structure databases

ProteinModelPortaliA6NMN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM170 family.Curated

Phylogenomic databases

eggNOGiENOG410IZBZ Eukaryota
ENOG411181D LUCA
GeneTreeiENSGT00530000063963
HOGENOMiHOG000112445
HOVERGENiHBG082564
InParanoidiA6NMN3
OMAiEYQSYSQ
OrthoDBiEOG091G0GNZ
PhylomeDBiA6NMN3
TreeFamiTF337124

Family and domain databases

InterProiView protein in InterPro
IPR033377 FAM170B
PANTHERiPTHR33517:SF2 PTHR33517:SF2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NMN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG
60 70 80 90 100
PAIPREEGLY FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN
110 120 130 140 150
AAPQSVCAFY THVQTVRGVA VAWETEAGFE PVTRKPRIHE AQFIKRQRWN
160 170 180 190 200
GSSFEMASNT DMRWDLEACK SNCSPEPEDI DLLECCLQEL REPPDWLVTT
210 220 230 240 250
NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM LERRRAQGQA
260 270 280
HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ
Length:283
Mass (Da):32,092
Last modified:July 24, 2007 - v1
Checksum:i4DEE3A62AF7BE9DF
GO

Sequence cautioni

The sequence AAH29839 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH47597 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84S → F in AAH29839 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03706269R → L. Corresponds to variant dbSNP:rs17773851Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084727 Genomic DNA No translation available.
BC029839 mRNA Translation: AAH29839.1 Different initiation.
BC047597 mRNA Translation: AAH47597.1 Different initiation.
CCDSiCCDS53536.1
RefSeqiNP_001157956.1, NM_001164484.1
UniGeneiHs.646291

Genome annotation databases

EnsembliENST00000311787; ENSP00000308292; ENSG00000172538
GeneIDi170370
KEGGihsa:170370
UCSCiuc001jhj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084727 Genomic DNA No translation available.
BC029839 mRNA Translation: AAH29839.1 Different initiation.
BC047597 mRNA Translation: AAH47597.1 Different initiation.
CCDSiCCDS53536.1
RefSeqiNP_001157956.1, NM_001164484.1
UniGeneiHs.646291

3D structure databases

ProteinModelPortaliA6NMN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308292

PTM databases

iPTMnetiA6NMN3
PhosphoSitePlusiA6NMN3

Polymorphism and mutation databases

BioMutaiFAM170B

Proteomic databases

PaxDbiA6NMN3
PRIDEiA6NMN3
ProteomicsDBi1549
TopDownProteomicsiA6NMN3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311787; ENSP00000308292; ENSG00000172538
GeneIDi170370
KEGGihsa:170370
UCSCiuc001jhj.4 human

Organism-specific databases

CTDi170370
EuPathDBiHostDB:ENSG00000172538.6
GeneCardsiFAM170B
HGNCiHGNC:19736 FAM170B
HPAiHPA043899
HPA050610
neXtProtiNX_A6NMN3
PharmGKBiPA162387168
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZBZ Eukaryota
ENOG411181D LUCA
GeneTreeiENSGT00530000063963
HOGENOMiHOG000112445
HOVERGENiHBG082564
InParanoidiA6NMN3
OMAiEYQSYSQ
OrthoDBiEOG091G0GNZ
PhylomeDBiA6NMN3
TreeFamiTF337124

Miscellaneous databases

GenomeRNAii170370
PROiPR:A6NMN3

Gene expression databases

BgeeiENSG00000172538 Expressed in 9 organ(s), highest expression level in testis
CleanExiHS_FAM170B
GenevisibleiA6NMN3 HS

Family and domain databases

InterProiView protein in InterPro
IPR033377 FAM170B
PANTHERiPTHR33517:SF2 PTHR33517:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF170B_HUMAN
AccessioniPrimary (citable) accession number: A6NMN3
Secondary accession number(s): Q86WY6, Q8N6K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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