FAM170B

Functionⁱ

Plays a role in fertilization through the acrosome reaction.By similarity

GO - Biological processⁱ

positive regulation of acrosome reaction Source: UniProtKB
regulation of fertilization Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM170BCurated Alternative name(s): Acrosome-related protein1 Publication
Gene namesⁱ	Name:FAM170BImported Synonyms:C10orf73Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172538.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19736 FAM170B
neXtProtⁱ	NX_A6NMN3

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA162387168

PharmGKBⁱ

PA162387168

Polymorphism and mutation databases

BioMutaⁱ	FAM170B

BioMutaⁱ

FAM170B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000310494	1 – 283	Protein FAM170BAdd BLAST		283

Proteomic databases

PaxDbⁱ	A6NMN3
PRIDEⁱ	A6NMN3
ProteomicsDBⁱ	1549
TopDownProteomicsⁱ	A6NMN3

PTM databases

iPTMnetⁱ	A6NMN3
PhosphoSitePlusⁱ	A6NMN3

Expressionⁱ

Tissue specificityⁱ

Exclusively expressed in adult testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172538 Expressed in 9 organ(s), highest expression level in testis
CleanExⁱ	HS_FAM170B
Genevisibleⁱ	A6NMN3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043899 HPA050610

HPAⁱ

HPA043899
HPA050610

Interactionⁱ

Subunit structureⁱ

Interacts with GOPC.1 Publication

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000308292

STRINGⁱ

9606.ENSP00000308292

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NMN3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FAM170 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IZBZ Eukaryota ENOG411181D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063963
HOGENOMⁱ	HOG000112445
HOVERGENⁱ	HBG082564
InParanoidⁱ	A6NMN3
OMAⁱ	EYQSYSQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GNZ
PhylomeDBⁱ	A6NMN3
TreeFamⁱ	TF337124

Family and domain databases

InterProⁱ	View protein in InterPro IPR033377 FAM170B
PANTHERⁱ	PTHR33517:SF2 PTHR33517:SF2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A6NMN3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG 
        60         70         80         90        100
PAIPREEGLY FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN 
       110        120        130        140        150
AAPQSVCAFY THVQTVRGVA VAWETEAGFE PVTRKPRIHE AQFIKRQRWN 
       160        170        180        190        200
GSSFEMASNT DMRWDLEACK SNCSPEPEDI DLLECCLQEL REPPDWLVTT 
       210        220        230        240        250
NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM LERRRAQGQA 
       260        270        280 
HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ

Length:283

Mass (Da):32,092

Last modified:July 24, 2007 - v1

Checksum:ⁱ4DEE3A62AF7BE9DF

GO

Sequence cautionⁱ

The sequence AAH29839 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH47597 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	84	S → F in AAH29839 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037062	69	R → L. Corresponds to variant dbSNP:rs17773851Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC084727 Genomic DNA No translation available. BC029839 mRNA Translation: AAH29839.1 Different initiation. BC047597 mRNA Translation: AAH47597.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53536.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001157956.1, NM_001164484.1
UniGeneⁱ	Hs.646291

Genome annotation databases

Ensemblⁱ	ENST00000311787; ENSP00000308292; ENSG00000172538
GeneIDⁱ	170370
KEGGⁱ	hsa:170370
UCSC genome browser More...UCSCⁱ	uc001jhj.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A6NMN3	Uncharacterized protein		MACMU		283	UniRef90_A6NMN3
FAM170B isoform 1		PONAB		283
Uncharacterized protein		CERAT		283
Uncharacterized protein		RHIRO		283
Uncharacterized protein		PAPAN		283
+13

Protein	Similar proteins		Species	Score	Length	Source
A6NMN3	Uncharacterized protein		MANLE		283	UniRef50_A6NMN3
Uncharacterized protein		PANPA		283
Uncharacterized protein		CERAT		283
FAM170B isoform 1		PONAB		283
Uncharacterized protein		CHLSB		283
+79

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC084727 Genomic DNA No translation available. BC029839 mRNA Translation: AAH29839.1 Different initiation. BC047597 mRNA Translation: AAH47597.1 Different initiation.
CCDSⁱ	CCDS53536.1
RefSeqⁱ	NP_001157956.1, NM_001164484.1
UniGeneⁱ	Hs.646291

3D structure databases

ProteinModelPortalⁱ	A6NMN3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000308292

STRINGⁱ

9606.ENSP00000308292

PTM databases

iPTMnetⁱ	A6NMN3
PhosphoSitePlusⁱ	A6NMN3

Polymorphism and mutation databases

BioMutaⁱ	FAM170B

BioMutaⁱ

FAM170B

Proteomic databases

PaxDbⁱ	A6NMN3
PRIDEⁱ	A6NMN3
ProteomicsDBⁱ	1549
TopDownProteomicsⁱ	A6NMN3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000311787; ENSP00000308292; ENSG00000172538
GeneIDⁱ	170370
KEGGⁱ	hsa:170370
UCSCⁱ	uc001jhj.4 human

Organism-specific databases

CTDⁱ	170370
EuPathDBⁱ	HostDB:ENSG00000172538.6
GeneCardsⁱ	FAM170B
HGNCⁱ	HGNC:19736 FAM170B
HPAⁱ	HPA043899 HPA050610
neXtProtⁱ	NX_A6NMN3
PharmGKBⁱ	PA162387168
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZBZ Eukaryota ENOG411181D LUCA
GeneTreeⁱ	ENSGT00530000063963
HOGENOMⁱ	HOG000112445
HOVERGENⁱ	HBG082564
InParanoidⁱ	A6NMN3
OMAⁱ	EYQSYSQ
OrthoDBⁱ	EOG091G0GNZ
PhylomeDBⁱ	A6NMN3
TreeFamⁱ	TF337124

Miscellaneous databases

GenomeRNAiⁱ	170370
Protein Ontology More...PROⁱ	PR:A6NMN3

Gene expression databases

Bgeeⁱ	ENSG00000172538 Expressed in 9 organ(s), highest expression level in testis
CleanExⁱ	HS_FAM170B
Genevisibleⁱ	A6NMN3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033377 FAM170B
PANTHERⁱ	PTHR33517:SF2 PTHR33517:SF2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F170B_HUMAN
Accessionⁱ	A6NMN3Primary (citable) accession number: A6NMN3 Secondary accession number(s): Q86WY6, Q8N6K8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	July 24, 2007
	Last modified:	September 12, 2018
	This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - A6NMN3 (F170B_HUMAN)

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Protein FAM170B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ