UniProtKB - A6NMN3 (F170B_HUMAN)
Protein
Protein FAM170B
Gene
FAM170B
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in fertilization through the acrosome reaction.By similarity
GO - Biological processi
- positive regulation of acrosome reaction Source: UniProtKB
- regulation of fertilization Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | A6NMN3 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM170BCuratedAlternative name(s): Acrosome-related protein1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172538.6 |
HGNCi | HGNC:19736, FAM170B |
neXtProti | NX_A6NMN3 |
Subcellular locationi
Other locations
- acrosome 1 Publication
- acrosome outer membrane By similarity
Other locations
- acrosomal vesicle Source: UniProtKB
- outer acrosomal membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA162387168 |
Miscellaneous databases
Pharosi | A6NMN3, Tdark |
Polymorphism and mutation databases
BioMutai | FAM170B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000310494 | 1 – 283 | Protein FAM170BAdd BLAST | 283 |
Proteomic databases
PaxDbi | A6NMN3 |
PRIDEi | A6NMN3 |
ProteomicsDBi | 1549 |
TopDownProteomicsi | A6NMN3 |
PTM databases
iPTMneti | A6NMN3 |
PhosphoSitePlusi | A6NMN3 |
Expressioni
Tissue specificityi
Exclusively expressed in adult testis.1 Publication
Gene expression databases
Bgeei | ENSG00000172538, Expressed in testis and 18 other tissues |
Genevisiblei | A6NMN3, HS |
Organism-specific databases
HPAi | ENSG00000172538, Group enriched (blood, testis) |
Interactioni
Subunit structurei
Interacts with GOPC.
1 PublicationProtein-protein interaction databases
STRINGi | 9606.ENSP00000308292 |
Miscellaneous databases
RNActi | A6NMN3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM170 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S6PC, Eukaryota |
GeneTreei | ENSGT00940000162512 |
HOGENOMi | CLU_062038_1_0_1 |
InParanoidi | A6NMN3 |
OMAi | HAQYGIQ |
OrthoDBi | 1142827at2759 |
PhylomeDBi | A6NMN3 |
TreeFami | TF337124 |
Family and domain databases
InterProi | View protein in InterPro IPR033377, FAM170B IPR040879, Spt46-like |
PANTHERi | PTHR33517, PTHR33517, 1 hit PTHR33517:SF2, PTHR33517:SF2, 1 hit |
Pfami | View protein in Pfam PF17734, Spt46, 1 hit |
i Sequence
Sequence statusi: Complete.
A6NMN3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG
60 70 80 90 100
PAIPREEGLY FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN
110 120 130 140 150
AAPQSVCAFY THVQTVRGVA VAWETEAGFE PVTRKPRIHE AQFIKRQRWN
160 170 180 190 200
GSSFEMASNT DMRWDLEACK SNCSPEPEDI DLLECCLQEL REPPDWLVTT
210 220 230 240 250
NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM LERRRAQGQA
260 270 280
HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ
Sequence cautioni
The sequence AAH29839 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH47597 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 84 | S → F in AAH29839 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037062 | 69 | R → L. Corresponds to variant dbSNP:rs17773851Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084727 Genomic DNA No translation available. BC029839 mRNA Translation: AAH29839.1 Different initiation. BC047597 mRNA Translation: AAH47597.1 Different initiation. |
CCDSi | CCDS53536.1 |
RefSeqi | NP_001157956.1, NM_001164484.1 |
Genome annotation databases
Ensembli | ENST00000311787; ENSP00000308292; ENSG00000172538 |
GeneIDi | 170370 |
KEGGi | hsa:170370 |
UCSCi | uc001jhj.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084727 Genomic DNA No translation available. BC029839 mRNA Translation: AAH29839.1 Different initiation. BC047597 mRNA Translation: AAH47597.1 Different initiation. |
CCDSi | CCDS53536.1 |
RefSeqi | NP_001157956.1, NM_001164484.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000308292 |
PTM databases
iPTMneti | A6NMN3 |
PhosphoSitePlusi | A6NMN3 |
Polymorphism and mutation databases
BioMutai | FAM170B |
Proteomic databases
PaxDbi | A6NMN3 |
PRIDEi | A6NMN3 |
ProteomicsDBi | 1549 |
TopDownProteomicsi | A6NMN3 |
Protocols and materials databases
Antibodypediai | 61247, 33 antibodies |
Genome annotation databases
Ensembli | ENST00000311787; ENSP00000308292; ENSG00000172538 |
GeneIDi | 170370 |
KEGGi | hsa:170370 |
UCSCi | uc001jhj.4, human |
Organism-specific databases
CTDi | 170370 |
EuPathDBi | HostDB:ENSG00000172538.6 |
GeneCardsi | FAM170B |
HGNCi | HGNC:19736, FAM170B |
HPAi | ENSG00000172538, Group enriched (blood, testis) |
neXtProti | NX_A6NMN3 |
PharmGKBi | PA162387168 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6PC, Eukaryota |
GeneTreei | ENSGT00940000162512 |
HOGENOMi | CLU_062038_1_0_1 |
InParanoidi | A6NMN3 |
OMAi | HAQYGIQ |
OrthoDBi | 1142827at2759 |
PhylomeDBi | A6NMN3 |
TreeFami | TF337124 |
Enzyme and pathway databases
PathwayCommonsi | A6NMN3 |
Miscellaneous databases
BioGRID-ORCSi | 170370, 3 hits in 844 CRISPR screens |
GenomeRNAii | 170370 |
Pharosi | A6NMN3, Tdark |
PROi | PR:A6NMN3 |
RNActi | A6NMN3, protein |
Gene expression databases
Bgeei | ENSG00000172538, Expressed in testis and 18 other tissues |
Genevisiblei | A6NMN3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033377, FAM170B IPR040879, Spt46-like |
PANTHERi | PTHR33517, PTHR33517, 1 hit PTHR33517:SF2, PTHR33517:SF2, 1 hit |
Pfami | View protein in Pfam PF17734, Spt46, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F170B_HUMAN | |
Accessioni | A6NMN3Primary (citable) accession number: A6NMN3 Secondary accession number(s): Q86WY6, Q8N6K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | December 2, 2020 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations