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Entry version 73 (08 May 2019)
Sequence version 1 (24 Jul 2007)
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Protein

Protein INSYN2B

Gene

INSYN2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein INSYN2BCurated
Alternative name(s):
Inhibitory synaptic factor family member 2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INSYN2BImported
Synonyms:C5orf57, FAM196B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:37271 INSYN2B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NMK8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000204767

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660363

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM196B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003491831 – 535Protein INSYN2BAdd BLAST535

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A6NMK8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A6NMK8

PRoteomics IDEntifications database

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PRIDEi
A6NMK8

ProteomicsDB human proteome resource

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ProteomicsDBi
1544

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A6NMK8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A6NMK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000204767 Expressed in 56 organ(s), highest expression level in corpus callosum

Organism-specific databases

Human Protein Atlas

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HPAi
HPA047227

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A6NMK8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili411 – 448Sequence analysisAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the INSYN2 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IMEG Eukaryota
ENOG4111HWX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000155526

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A6NMK8

Identification of Orthologs from Complete Genome Data

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OMAi
FRNIAIQ

Database of Orthologous Groups

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OrthoDBi
520296at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A6NMK8

TreeFam database of animal gene trees

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TreeFami
TF333465

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029337 INSYN2

The PANTHER Classification System

More...
PANTHERi
PTHR28682 PTHR28682, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15265 FAM196, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NMK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQNMKVRP VLLKRNSLES VEFVKQPHHR RSKSQQVRFK EDGTTKNPTG
60 70 80 90 100
LAEVDVQTPE DPAVMGKTQA TRHHLPPTYS LSFPRSQKAG GFRNIAIQTS
110 120 130 140 150
PSLRKHFPVF KRKRLTASKS LVEMPTASQS AIQVNGNLSE QDIVSSDLAY
160 170 180 190 200
LRLAQHLEDG PRRVKVSHAF LPRVPKVQSN GPVSICLEAG TWRSLEKATA
210 220 230 240 250
AIQVPDDIYH SPSWEARESA LSPDRSAEVS NSIHPLDDTR PGDGRRVTPL
260 270 280 290 300
DSEKSTSCLN ATSVASHTPG TEELKPELLL PKDNSDDKDL GSLSSQSKET
310 320 330 340 350
CVPSSPRTHS SPSQGSHSQP AHPGRASDCP SSSNNHQNLV SLKTNSASKS
360 370 380 390 400
APGCQEQTAN NPTESDTLEF PNCPGSNHLP SSLSRSETKL QSNREISDIN
410 420 430 440 450
QIHLARGELC DLQGRLQSVE ESLHSNQEKI KVLLNVIQDL EKARALTEGR
460 470 480 490 500
NFYRTGQDLN NCSTCQNTAC IIYSVEYDFR QQEGRFHEVL QSLEEAEPVE
510 520 530
EASPPPKSPA EPPAPEKQDL RRKTKKVKKK CFWWI
Length:535
Mass (Da):59,204
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE9F3BE78916F2FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230S → R in AK055998 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC008449 Genomic DNA No translation available.
AK055998 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47336.1

NCBI Reference Sequences

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RefSeqi
NP_001123363.1, NM_001129891.2
NP_001333233.1, NM_001346304.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377365; ENSP00000366582; ENSG00000204767

Database of genes from NCBI RefSeq genomes

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GeneIDi
100131897

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:100131897

UCSC genome browser

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UCSCi
uc003mag.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008449 Genomic DNA No translation available.
AK055998 mRNA No translation available.
CCDSiCCDS47336.1
RefSeqiNP_001123363.1, NM_001129891.2
NP_001333233.1, NM_001346304.1

3D structure databases

SMRiA6NMK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366582

PTM databases

iPTMnetiA6NMK8
PhosphoSitePlusiA6NMK8

Polymorphism and mutation databases

BioMutaiFAM196B

Proteomic databases

jPOSTiA6NMK8
PaxDbiA6NMK8
PRIDEiA6NMK8
ProteomicsDBi1544

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377365; ENSP00000366582; ENSG00000204767
GeneIDi100131897
KEGGihsa:100131897
UCSCiuc003mag.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100131897

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM196B
HGNCiHGNC:37271 INSYN2B
HPAiHPA047227
neXtProtiNX_A6NMK8
OpenTargetsiENSG00000204767
PharmGKBiPA165660363

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMEG Eukaryota
ENOG4111HWX LUCA
GeneTreeiENSGT00530000063787
HOGENOMiHOG000155526
InParanoidiA6NMK8
OMAiFRNIAIQ
OrthoDBi520296at2759
PhylomeDBiA6NMK8
TreeFamiTF333465

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100131897

Protein Ontology

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PROi
PR:A6NMK8

Gene expression databases

BgeeiENSG00000204767 Expressed in 56 organ(s), highest expression level in corpus callosum

Family and domain databases

InterProiView protein in InterPro
IPR029337 INSYN2
PANTHERiPTHR28682 PTHR28682, 1 hit
PfamiView protein in Pfam
PF15265 FAM196, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINY2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NMK8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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