UniProtKB - A6NMH8 (A6NMH8_HUMAN)
Protein
Tetraspanin
Gene
CD81
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Biological processi
- cellular response to low-density lipoprotein particle stimulus Source: Ensembl
- macrophage fusion Source: Ensembl
- myoblast fusion involved in skeletal muscle regeneration Source: Ensembl
- osteoclast fusion Source: Ensembl
- positive regulation of B cell activation Source: Ensembl
- positive regulation of B cell receptor signaling pathway Source: Ensembl
- positive regulation of inflammatory response to antigenic stimulus Source: Ensembl
- positive regulation of receptor clustering Source: Ensembl
- positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl
- positive regulation of T-helper 2 cell cytokine production Source: Ensembl
- receptor internalization Source: Ensembl
- regulation of macrophage migration Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: TetraspaninUniRule annotation |
Gene namesi | Name:CD81Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1701, CD81 |
VEuPathDBi | HostDB:ENSG00000110651.11 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 96 – 122 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 128 – 152 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 240 – 264 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5002700227 | 18 – 274 | TetraspaninSequence analysisAdd BLAST | 257 |
Proteomic databases
EPDi | A6NMH8 |
MaxQBi | A6NMH8 |
PeptideAtlasi | A6NMH8 |
PRIDEi | A6NMH8 |
ProteomicsDBi | 1541 |
PTM databases
SwissPalmi | A6NMH8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110651, Expressed in stromal cell of endometrium and 243 other tissues |
ExpressionAtlasi | A6NMH8, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000158805 |
OMAi | HETLSCC |
PhylomeDBi | A6NMH8 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
A6NMH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWCGWSFSWQ PVHWVRSACG CSLTWVSWSL ASSSSRSLLK VGELGMAPFV
60 70 80 90 100
HARAGKTKAQ LAGGVILGVA LWLRHDPQTT NLLYLELGDK PAPNTFYVGI
110 120 130 140 150
YILIAVGAVM MFVGFLGCYG AIQESQCLLG TFFTCLVILF ACEVAAGIWG
160 170 180 190 200
FVNKDQIAKD VKQFYDQALQ QAVVDDDANN AKAVVKTFHE TLDCCGSSTL
210 220 230 240 250
TALTTSVLKN NLCPSGSNII SNLFKEDCHQ KIDDLFSGKL YLIGIAAIVV
260 270
AVIMIFEMIL SMVLCCGIRN SSVY
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP60033 | CD81_HUMAN | CD81 antigen | CD81 TAPA1, TSPAN28 | 236 | Annotation score: | ||
E9PJK1 | E9PJK1_HUMAN | Tetraspanin | CD81 | 165 | Annotation score: | ||
E9PRJ8 | E9PRJ8_HUMAN | Tetraspanin | CD81 | 209 | Annotation score: | ||
E9PIF1 | E9PIF1_HUMAN | Tetraspanin | CD81 | 242 | Annotation score: | ||
H0YEE2 | H0YEE2_HUMAN | Tetraspanin | CD81 | 148 | Annotation score: | ||
H0YDJ9 | H0YDJ9_HUMAN | Tetraspanin | CD81 | 225 | Annotation score: | ||
H0YDL9 | H0YDL9_HUMAN | Tetraspanin | CD81 | 221 | Annotation score: | ||
E9PQV4 | E9PQV4_HUMAN | CD81 antigen | CD81 | 99 | Annotation score: | ||
E9PM31 | E9PM31_HUMAN | CD81 antigen | CD81 | 92 | Annotation score: | ||
E9PPF5 | E9PPF5_HUMAN | CD81 antigen | CD81 | 51 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124057 Genomic DNA No translation available. AC129929 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000381036; ENSP00000370424; ENSG00000110651 |
UCSCi | uc057xxr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124057 Genomic DNA No translation available. AC129929 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | A6NMH8 |
Proteomic databases
EPDi | A6NMH8 |
MaxQBi | A6NMH8 |
PeptideAtlasi | A6NMH8 |
PRIDEi | A6NMH8 |
ProteomicsDBi | 1541 |
Protocols and materials databases
Antibodypediai | 1570, 1253 antibodies |
Genome annotation databases
Ensembli | ENST00000381036; ENSP00000370424; ENSG00000110651 |
UCSCi | uc057xxr.1, human |
Organism-specific databases
HGNCi | HGNC:1701, CD81 |
OpenTargetsi | ENSG00000110651 |
VEuPathDBi | HostDB:ENSG00000110651.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158805 |
OMAi | HETLSCC |
PhylomeDBi | A6NMH8 |
Miscellaneous databases
ChiTaRSi | CD81, human |
Gene expression databases
Bgeei | ENSG00000110651, Expressed in stromal cell of endometrium and 243 other tissues |
ExpressionAtlasi | A6NMH8, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A6NMH8_HUMAN | |
Accessioni | A6NMH8Primary (citable) accession number: A6NMH8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |