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Protein

Leucine-rich repeat-containing protein 53

Gene

LRRC53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 53
Gene namesi
Name:LRRC53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162621.6
HGNCiHGNC:25255 LRRC53
neXtProtiNX_A6NM62

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173671 – 1247Leucine-rich repeat-containing protein 53Add BLAST1247

Proteomic databases

PaxDbiA6NM62
PRIDEiA6NM62
ProteomicsDBi1517

PTM databases

iPTMnetiA6NM62
PhosphoSitePlusiA6NM62

Expressioni

Gene expression databases

BgeeiENSG00000162621 Expressed in 14 organ(s), highest expression level in heart

Organism-specific databases

HPAiHPA054062

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000294635

Structurei

3D structure databases

ProteinModelPortaliA6NM62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 55LRR 1Add BLAST22
Repeati58 – 79LRR 2Add BLAST22
Repeati82 – 102LRR 3Add BLAST21
Repeati108 – 129LRR 4Add BLAST22
Repeati132 – 153LRR 5Add BLAST22
Repeati158 – 179LRR 6Add BLAST22
Repeati182 – 203LRR 7Add BLAST22
Domaini214 – 271LRRCTAdd BLAST58

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00800000124223
HOGENOMiHOG000113373
InParanoidiA6NM62
OMAiICKYVPC
OrthoDBiEOG091G0899
PhylomeDBiA6NM62
TreeFamiTF341942

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

A6NM62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLVAACPE SCVVCTKDVT LCHQLTYIVA APMTTRVLII TDGYLSSIES
60 70 80 90 100
TNLSLLFNLA LLSLSRNGIE DVQEDALHGL TMLRTLLLEH NQISSSSLTD
110 120 130 140 150
HTFSKLHSLQ VLVLSNNALR TLRGSWFRNT SGLTRLQLDG NQITNLTDSS
160 170 180 190 200
FGGTNLHSLR YLDLSNNFIS YIGKDAFRPL PQLQEVDLSR NRLAHMPDVF
210 220 230 240 250
TPLKQLILLS LDKNQWSCTC DLHPLARFLR NYIKSSAHTL RNAKDLNCQP
260 270 280 290 300
STAAVAAAQS VLRLSETNCD SKAPNFTLVL KDRSPLLPGP DVALLTVLGF
310 320 330 340 350
AGAVGLTCLG LVVFNWKLHQ GKANEHTSEN LCCRTFDEPL CAHEARNYHT
360 370 380 390 400
KGYCNCHLTQ ENEIKVMSTV GSRKEMPLLQ ENSHQATSAS ESATLDGSFR
410 420 430 440 450
NLKKKDRGVG STLFCQDGRL LHSECSEPPG NMRAFNEAGL LTTYNPRKVQ
460 470 480 490 500
KLWNLEPGEV QPQTLQHHII RTEDISSDIF RRRYATPASA LAGESLEKRL
510 520 530 540 550
TNESWQPPIE KEDNGLHPHR QRHFITSSSS KPCEPEEHYV QKIVQKNRSK
560 570 580 590 600
YDDPCGLLKQ SKPRYFQPNN SLICKYVPCE QFEDYMKEKK PNRRQHSKPE
610 620 630 640 650
KEQIQINSAI EKFLMSEDNI DLSGLSTKTK KAYSPKRVIF HDPDLVEINR
660 670 680 690 700
SMMSPKISTP WKRQKNQSNQ LTKLDVKKFS NTGERNKGEK WFTNSWVLKR
710 720 730 740 750
KRTPQSDLKG KIKGQNLKLN LHPFRKVRVH PEKSLSSLPK QCKQVLLPPK
760 770 780 790 800
KLSKTSETEA KINTVCSADF LQQSESSNYV RLTSKRLPLK HDSKQTPYYQ
810 820 830 840 850
RNTKRAPLLS ANNLRVVNQS SIESSCYSAG HIPDGNTSKL PQPTPTDAEH
860 870 880 890 900
RHSHSQFSTE QMEDATQLES KVLSYLATTW ENTGSDVLPF QHSRRATDQG
910 920 930 940 950
TTESTEHMGQ NVSKTSELNQ FSLSPRNQTQ LLDAHKTDSY NKEYTLDQNE
960 970 980 990 1000
ALQHREQNSS HAQLENKEKT LMTKPQISHQ IVENCIMDKE ENDVEKKLSK
1010 1020 1030 1040 1050
TETYDSSLIP QTQSKNNLSF MKTNSIPYQN RIELPKDIST SPVSSQAVWH
1060 1070 1080 1090 1100
LTNSSEKGID STNALPRNDG TEALEIKIVG KEEKNMLDES KTDSSMLTQI
1110 1120 1130 1140 1150
SQMTLKGITK ERQQTWENGT SEKYILHDAS SAEETITAKD LSITSSHETQ
1160 1170 1180 1190 1200
NRILCSEVDP EVNSNVHNFR EVQNIQPDKD SAHKEGAMTV ETHEALSFLP
1210 1220 1230 1240
GLKDSFEAEN EVFLVPSRIN EAENSAPKPV LYPPSAEYAT TSPLETE
Length:1,247
Mass (Da):140,742
Last modified:July 22, 2008 - v2
Checksum:iA22DDB8BB3BEA9B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105271 Genomic DNA No translation available.
RefSeqiXP_016858569.1, XM_017003080.1

Genome annotation databases

EnsembliENST00000294635; ENSP00000294635; ENSG00000162621
GeneIDi105378803
KEGGihsa:105378803
UCSCiuc057hqj.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105271 Genomic DNA No translation available.
RefSeqiXP_016858569.1, XM_017003080.1

3D structure databases

ProteinModelPortaliA6NM62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000294635

PTM databases

iPTMnetiA6NM62
PhosphoSitePlusiA6NM62

Proteomic databases

PaxDbiA6NM62
PRIDEiA6NM62
ProteomicsDBi1517

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294635; ENSP00000294635; ENSG00000162621
GeneIDi105378803
KEGGihsa:105378803
UCSCiuc057hqj.1 human

Organism-specific databases

CTDi105378803
EuPathDBiHostDB:ENSG00000162621.6
GeneCardsiLRRC53
HGNCiHGNC:25255 LRRC53
HPAiHPA054062
neXtProtiNX_A6NM62
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00800000124223
HOGENOMiHOG000113373
InParanoidiA6NM62
OMAiICKYVPC
OrthoDBiEOG091G0899
PhylomeDBiA6NM62
TreeFamiTF341942

Miscellaneous databases

PROiPR:A6NM62

Gene expression databases

BgeeiENSG00000162621 Expressed in 14 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC53_HUMAN
AccessioniPrimary (citable) accession number: A6NM62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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