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Protein

Putative T-complex protein 1 subunit theta-like 1

Gene

CCT8L1P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative T-complex protein 1 subunit theta-like 1
Gene namesi
Name:CCT8L1P
Synonyms:CCT8L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32153 CCT8L1P
neXtProtiNX_A6NM43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473381 – 557Putative T-complex protein 1 subunit theta-like 1Add BLAST557

Proteomic databases

PRIDEiA6NM43
ProteomicsDBi1511

Expressioni

Gene expression databases

CleanExiHS_CCT8L1

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA6NM43
SMRiA6NM43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
HOVERGENiHBG098338
InParanoidiA6NM43
PhylomeDBiA6NM43

Family and domain databases

Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits

Sequencei

Sequence statusi: Complete.

A6NM43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLANVIRPC
60 70 80 90 100
YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAAQTQAEN
110 120 130 140 150
SGDGTAFVVL LTEALLEQAE QLLKFGLPRP QLREAYATAT AEVLATLPSL
160 170 180 190 200
AIQSLGPLED PSWALHSVMN THTLPPMNHL TKLVAHACWA IKELDGSFKP
210 220 230 240 250
ERVGVCTLHG GTLEDSCLLQ GLAISGKLCG QMAAVLSGAR VALFACPFGP
260 270 280 290 300
AHPNAPATAC LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
310 320 330 340 350
EETLTLADKY GIVVIQARSR MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV
360 370 380 390 400
YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHSIDAYF
410 420 430 440 450
QPCQDPRLIP GAGATEMALA KMLSDKGSRL EGPNGPAFLA FARALKYLPK
460 470 480 490 500
TLAENAGLAV SDVVAEMSGV HQGGNLLMGV GAEGIINVAQ EGVWDTLIVK
510 520 530 540 550
AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ QIWNPDSKKT KKRPPPVEKK

KILGMNN
Length:557
Mass (Da):59,514
Last modified:July 24, 2007 - v1
Checksum:i536C5CED92C7F708
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046039217C → S. Corresponds to variant dbSNP:rs6969304Ensembl.1
Natural variantiVAR_046040308D → N. Corresponds to variant dbSNP:rs12672139Ensembl.1
Natural variantiVAR_046041395S → G. Corresponds to variant dbSNP:rs6953943Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005631 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW53969.1

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005631 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW53969.1

3D structure databases

ProteinModelPortaliA6NM43
SMRiA6NM43
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA6NM43
ProteomicsDBi1511

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiCCT8L1P
HGNCiHGNC:32153 CCT8L1P
neXtProtiNX_A6NM43
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
HOVERGENiHBG098338
InParanoidiA6NM43
PhylomeDBiA6NM43

Gene expression databases

CleanExiHS_CCT8L1

Family and domain databases

Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTCPQL_HUMAN
AccessioniPrimary (citable) accession number: A6NM43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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