UniProtKB - A6NM36 (LRC30_HUMAN)
Protein
Leucine-rich repeat-containing protein 30
Gene
LRRC30
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein serine/threonine phosphatase activity Source: GO_Central
GO - Biological processi
- signal transduction Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 30 |
Gene namesi | Name:LRRC30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30219, LRRC30 |
neXtProti | NX_A6NM36 |
VEuPathDBi | HostDB:ENSG00000206422.2 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000206422 |
PharmGKBi | PA134945901 |
Miscellaneous databases
Pharosi | A6NM36, Tdark |
Genetic variation databases
BioMutai | LRRC30 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCurated | |||
ChainiPRO_0000310986 | 2 – 301 | Leucine-rich repeat-containing protein 30Add BLAST | 300 |
Proteomic databases
PaxDbi | A6NM36 |
PRIDEi | A6NM36 |
ProteomicsDBi | 1509 |
PTM databases
iPTMneti | A6NM36 |
PhosphoSitePlusi | A6NM36 |
Expressioni
Gene expression databases
Bgeei | ENSG00000206422, Expressed in muscle of leg and 15 other tissues |
Organism-specific databases
HPAi | ENSG00000206422, Tissue enriched (skeletal) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000372959 |
Miscellaneous databases
RNActi | A6NM36, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 72 – 93 | LRR 1Add BLAST | 22 | |
Repeati | 95 – 116 | LRR 2Add BLAST | 22 | |
Repeati | 118 – 139 | LRR 3Add BLAST | 22 | |
Repeati | 141 – 163 | LRR 4Add BLAST | 23 | |
Repeati | 164 – 185 | LRR 5Add BLAST | 22 | |
Repeati | 187 – 208 | LRR 6Add BLAST | 22 | |
Repeati | 210 – 231 | LRR 7Add BLAST | 22 | |
Repeati | 233 – 254 | LRR 8Add BLAST | 22 | |
Repeati | 265 – 287 | LRR 9Add BLAST | 23 |
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000161019 |
HOGENOMi | CLU_000288_18_15_1 |
InParanoidi | A6NM36 |
OMAi | LQIFIVE |
OrthoDBi | 484111at2759 |
PhylomeDBi | A6NM36 |
TreeFami | TF333627 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 6 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 8 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A6NM36-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGARQSRASS KDKGPKRMLF TGRRQKFSPW DDALLSGRDP RSLLKRGMHH
60 70 80 90 100
VSFSLVTRGM TDIPDFLWGL SEVQKLNLSH NQLRVLPPEV GKLTRIVVLN
110 120 130 140 150
LCGNRLKSLP REVSLLQCLK VLFVNMNCLT EVPAELSLCR KLEVLSLSHN
160 170 180 190 200
CLSQLPACFA DLSRLRKLNL SNNFFAHIPM CVFSLKELIF LHVGSNRLEN
210 220 230 240 250
IAESIQHLAS LQIFIAEGNN IHSFPRSLCL VTSLELLNLN NNDIQTLPSE
260 270 280 290 300
LHLLCRLVRI AWNPMDKGLH ISHNPLSKPL PELVEGGLEM LFGYLKDKKH
T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP005270 Genomic DNA No translation available. |
CCDSi | CCDS42409.1 |
RefSeqi | NP_001099051.1, NM_001105581.1 |
Genome annotation databases
Ensembli | ENST00000383467; ENSP00000372959; ENSG00000206422 |
GeneIDi | 339291 |
KEGGi | hsa:339291 |
UCSCi | uc010wzk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP005270 Genomic DNA No translation available. |
CCDSi | CCDS42409.1 |
RefSeqi | NP_001099051.1, NM_001105581.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000372959 |
PTM databases
iPTMneti | A6NM36 |
PhosphoSitePlusi | A6NM36 |
Genetic variation databases
BioMutai | LRRC30 |
Proteomic databases
PaxDbi | A6NM36 |
PRIDEi | A6NM36 |
ProteomicsDBi | 1509 |
Protocols and materials databases
Antibodypediai | 66148, 7 antibodies |
Genome annotation databases
Ensembli | ENST00000383467; ENSP00000372959; ENSG00000206422 |
GeneIDi | 339291 |
KEGGi | hsa:339291 |
UCSCi | uc010wzk.3, human |
Organism-specific databases
CTDi | 339291 |
GeneCardsi | LRRC30 |
HGNCi | HGNC:30219, LRRC30 |
HPAi | ENSG00000206422, Tissue enriched (skeletal) |
neXtProti | NX_A6NM36 |
OpenTargetsi | ENSG00000206422 |
PharmGKBi | PA134945901 |
VEuPathDBi | HostDB:ENSG00000206422.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000161019 |
HOGENOMi | CLU_000288_18_15_1 |
InParanoidi | A6NM36 |
OMAi | LQIFIVE |
OrthoDBi | 484111at2759 |
PhylomeDBi | A6NM36 |
TreeFami | TF333627 |
Miscellaneous databases
BioGRID-ORCSi | 339291, 1 hit in 868 CRISPR screens |
GenomeRNAii | 339291 |
Pharosi | A6NM36, Tdark |
PROi | PR:A6NM36 |
RNActi | A6NM36, protein |
Gene expression databases
Bgeei | ENSG00000206422, Expressed in muscle of leg and 15 other tissues |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 6 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRC30_HUMAN | |
Accessioni | A6NM36Primary (citable) accession number: A6NM36 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM