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Protein

Olfactory receptor 2AG2

Gene

OR2AG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG2
Gene namesi
Name:OR2AG2
Synonyms:OR2AG2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000188124.2
HGNCiHGNC:15143 OR2AG2
neXtProtiNX_A6NM03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 56CytoplasmicSequence analysis5
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 97ExtracellularSequence analysisAdd BLAST20
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 205ExtracellularSequence analysisAdd BLAST45
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 244CytoplasmicSequence analysisAdd BLAST18
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 271ExtracellularSequence analysis6
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 316CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188124
PharmGKBiPA32127

Polymorphism and mutation databases

BioMutaiOR2AG2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123431 – 316Olfactory receptor 2AG2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NM03
PRIDEiA6NM03
ProteomicsDBi1502

PTM databases

iPTMnetiA6NM03
PhosphoSitePlusiA6NM03

Expressioni

Gene expression databases

BgeeiENSG00000188124 Expressed in 2 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_OR2AG2
ExpressionAtlasiA6NM03 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342697

Structurei

3D structure databases

ProteinModelPortaliA6NM03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGT4 Eukaryota
ENOG4111C5R LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiA6NM03
KOiK04257
OMAiSWEIRHL
OrthoDBiEOG091G0FFK
PhylomeDBiA6NM03
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NM03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT
60 70 80 90 100
IEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGSA EDLLLAFMAY DRYVAICHPL KYMTLMSPRV CWIMVATSWI
160 170 180 190 200
LASLIAIGHT MYTMHLPFCV SWEIRHLLCE IPPLLKLACA DTSRYELIIY
210 220 230 240 250
VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT CSSHLIVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYIL LAHSTL
Length:316
Mass (Da):35,270
Last modified:July 24, 2007 - v1
Checksum:i0B2E3D549FEB7FF1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03749728Y → C1 PublicationCorresponds to variant dbSNP:rs7102536Ensembl.1
Natural variantiVAR_03749854R → P1 PublicationCorresponds to variant dbSNP:rs10839616Ensembl.1
Natural variantiVAR_03749987R → L. Corresponds to variant dbSNP:rs11828782Ensembl.1
Natural variantiVAR_037500299R → G. Corresponds to variant dbSNP:rs7924459Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091564 Genomic DNA No translation available.
BC140734 mRNA Translation: AAI40735.1
CCDSiCCDS31413.1
RefSeqiNP_001004490.1, NM_001004490.1
UniGeneiHs.534614

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124
ENST00000641124; ENSP00000493362; ENSG00000188124
ENST00000641169; ENSP00000493311; ENSG00000188124
GeneIDi338755
KEGGihsa:338755
UCSCiuc001meq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091564 Genomic DNA No translation available.
BC140734 mRNA Translation: AAI40735.1
CCDSiCCDS31413.1
RefSeqiNP_001004490.1, NM_001004490.1
UniGeneiHs.534614

3D structure databases

ProteinModelPortaliA6NM03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342697

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NM03
PhosphoSitePlusiA6NM03

Polymorphism and mutation databases

BioMutaiOR2AG2

Proteomic databases

PaxDbiA6NM03
PRIDEiA6NM03
ProteomicsDBi1502

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124
ENST00000641124; ENSP00000493362; ENSG00000188124
ENST00000641169; ENSP00000493311; ENSG00000188124
GeneIDi338755
KEGGihsa:338755
UCSCiuc001meq.2 human

Organism-specific databases

CTDi338755
EuPathDBiHostDB:ENSG00000188124.2
GeneCardsiOR2AG2
HGNCiHGNC:15143 OR2AG2
neXtProtiNX_A6NM03
OpenTargetsiENSG00000188124
PharmGKBiPA32127
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGT4 Eukaryota
ENOG4111C5R LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiA6NM03
KOiK04257
OMAiSWEIRHL
OrthoDBiEOG091G0FFK
PhylomeDBiA6NM03
TreeFamiTF337295

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii338755
PROiPR:A6NM03

Gene expression databases

BgeeiENSG00000188124 Expressed in 2 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_OR2AG2
ExpressionAtlasiA6NM03 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO2AG2_HUMAN
AccessioniPrimary (citable) accession number: A6NM03
Secondary accession number(s): B9EIM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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