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UniProtKB - A6NLX3 (SPDE4_HUMAN)
Protein
Speedy protein E4
Gene
SPDYE4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein kinase binding Source: GO_Central
GO - Biological processi
Enzyme and pathway databases
PathwayCommonsi | A6NLX3 |
SignaLinki | A6NLX3 |
Names & Taxonomyi
Protein namesi | Recommended name: Speedy protein E4Curated |
Gene namesi | Name:SPDYE4Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:35463, SPDYE4 |
MIMi | 617628, gene |
neXtProti | NX_A6NLX3 |
VEuPathDBi | HostDB:ENSG00000183318 |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA164726235 |
Miscellaneous databases
Pharosi | A6NLX3, Tdark |
Genetic variation databases
BioMutai | SPDYE4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349195 | 1 – 237 | Speedy protein E4Add BLAST | 237 |
Proteomic databases
PaxDbi | A6NLX3 |
PeptideAtlasi | A6NLX3 |
PRIDEi | A6NLX3 |
ProteomicsDBi | 1497 |
PTM databases
iPTMneti | A6NLX3 |
PhosphoSitePlusi | A6NLX3 |
Expressioni
Tissue specificityi
Predominantly expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000183318, Expressed in testis and 51 other tissues |
ExpressionAtlasi | A6NLX3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000183318, Tissue enriched (testis) |
Interactioni
Binary interactionsi
A6NLX3
GO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 132645, 11 interactors |
IntActi | A6NLX3, 60 interactors |
STRINGi | 9606.ENSP00000329522 |
Miscellaneous databases
RNActi | A6NLX3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 61 | DisorderedSequence analysisAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the Speedy/Ringo family.Curated
Phylogenomic databases
eggNOGi | ENOG502SSQN, Eukaryota |
GeneTreei | ENSGT00940000154173 |
HOGENOMi | CLU_070353_3_0_1 |
InParanoidi | A6NLX3 |
OMAi | LLCSMRW |
OrthoDBi | 1480540at2759 |
PhylomeDBi | A6NLX3 |
TreeFami | TF329827 |
Family and domain databases
InterProi | View protein in InterPro IPR020984, Speedy |
PANTHERi | PTHR31156, PTHR31156, 1 hit |
Pfami | View protein in Pfam PF11357, Spy1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A6NLX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGQARPPF EEESPQPSTT VRSPEVVVDD EVPGPSAPWI DPSPQPQSLG
60 70 80 90 100
LKRKSEWSDE SEEELEEELE LERAPEPEDT WVVETLCGLK MKLKRKRASS
110 120 130 140 150
VLPEHHEAFN RLLGDPVVQK FLAWDKDLRV SDKYLLAMVI AYFSRAGLFS
160 170 180 190 200
WQYQRIHFFL ALYLASDMEE DNQAPKQDIF SFLYGKNYSQ RPLFHKLRYQ
210 220 230
LLCSMRWRTW VSPEEMEEIQ AYDPEHWVWA RDRTLIS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KT05 | J3KT05_HUMAN | Speedy protein E4 | SPDYE4 | 91 | Annotation score: | ||
J3QR45 | J3QR45_HUMAN | Speedy protein E4 | SPDYE4 | 41 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009451 Genomic DNA No translation available. BC146949 mRNA Translation: AAI46950.1 BC146966 mRNA Translation: AAI46967.1 |
CCDSi | CCDS45609.1 |
RefSeqi | NP_001121548.1, NM_001128076.1 XP_005256689.1, XM_005256632.4 XP_005256690.1, XM_005256633.4 |
Genome annotation databases
Ensembli | ENST00000328794.10; ENSP00000329522.6; ENSG00000183318.12 ENST00000688021.1; ENSP00000510287.1; ENSG00000183318.12 ENST00000689094.1; ENSP00000509506.1; ENSG00000183318.12 |
GeneIDi | 388333 |
KEGGi | hsa:388333 |
MANE-Selecti | ENST00000689094.1; ENSP00000509506.1; NM_001394956.1; NP_001381885.1 |
UCSCi | uc010cnz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009451 Genomic DNA No translation available. BC146949 mRNA Translation: AAI46950.1 BC146966 mRNA Translation: AAI46967.1 |
CCDSi | CCDS45609.1 |
RefSeqi | NP_001121548.1, NM_001128076.1 XP_005256689.1, XM_005256632.4 XP_005256690.1, XM_005256633.4 |
3D structure databases
AlphaFoldDBi | A6NLX3 |
SMRi | A6NLX3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132645, 11 interactors |
IntActi | A6NLX3, 60 interactors |
STRINGi | 9606.ENSP00000329522 |
PTM databases
iPTMneti | A6NLX3 |
PhosphoSitePlusi | A6NLX3 |
Genetic variation databases
BioMutai | SPDYE4 |
Proteomic databases
PaxDbi | A6NLX3 |
PeptideAtlasi | A6NLX3 |
PRIDEi | A6NLX3 |
ProteomicsDBi | 1497 |
Protocols and materials databases
Antibodypediai | 6244, 8 antibodies from 7 providers |
DNASUi | 388333 |
Genome annotation databases
Ensembli | ENST00000328794.10; ENSP00000329522.6; ENSG00000183318.12 ENST00000688021.1; ENSP00000510287.1; ENSG00000183318.12 ENST00000689094.1; ENSP00000509506.1; ENSG00000183318.12 |
GeneIDi | 388333 |
KEGGi | hsa:388333 |
MANE-Selecti | ENST00000689094.1; ENSP00000509506.1; NM_001394956.1; NP_001381885.1 |
UCSCi | uc010cnz.1, human |
Organism-specific databases
CTDi | 388333 |
GeneCardsi | SPDYE4 |
HGNCi | HGNC:35463, SPDYE4 |
HPAi | ENSG00000183318, Tissue enriched (testis) |
MIMi | 617628, gene |
neXtProti | NX_A6NLX3 |
PharmGKBi | PA164726235 |
VEuPathDBi | HostDB:ENSG00000183318 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SSQN, Eukaryota |
GeneTreei | ENSGT00940000154173 |
HOGENOMi | CLU_070353_3_0_1 |
InParanoidi | A6NLX3 |
OMAi | LLCSMRW |
OrthoDBi | 1480540at2759 |
PhylomeDBi | A6NLX3 |
TreeFami | TF329827 |
Enzyme and pathway databases
PathwayCommonsi | A6NLX3 |
SignaLinki | A6NLX3 |
Miscellaneous databases
BioGRID-ORCSi | 388333, 11 hits in 1058 CRISPR screens |
GenomeRNAii | 388333 |
Pharosi | A6NLX3, Tdark |
PROi | PR:A6NLX3 |
RNActi | A6NLX3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183318, Expressed in testis and 51 other tissues |
ExpressionAtlasi | A6NLX3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR020984, Speedy |
PANTHERi | PTHR31156, PTHR31156, 1 hit |
Pfami | View protein in Pfam PF11357, Spy1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPDE4_HUMAN | |
Accessioni | A6NLX3Primary (citable) accession number: A6NLX3 Secondary accession number(s): B2RUZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | May 25, 2022 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families