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UniProtKB - A6NLX3 (SPDE4_HUMAN)

Entry version 89 (25 May 2022)
Sequence version 2 (02 Sep 2008)
Previous versions | rss
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Protein

Speedy protein E4

Gene

SPDYE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A6NLX3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		A6NLX3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Speedy protein E4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPDYE4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:35463, SPDYE4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617628, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NLX3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183318

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164726235

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NLX3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPDYE4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003491951 – 237Speedy protein E4Add BLAST237

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NLX3

PeptideAtlas

More...PeptideAtlasi		A6NLX3

PRoteomics IDEntifications database

More...PRIDEi		A6NLX3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1497

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NLX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NLX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183318, Expressed in testis and 51 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A6NLX3, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183318, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		132645, 11 interactors

Protein interaction database and analysis system

More...IntActi		A6NLX3, 60 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000329522

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NLX3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		A6NLX3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A6NLX3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 61DisorderedSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SSQN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070353_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NLX3

Identification of Orthologs from Complete Genome Data

More...OMAi		LLCSMRW

Database of Orthologous Groups

More...OrthoDBi		1480540at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NLX3

TreeFam database of animal gene trees

More...TreeFami		TF329827

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020984, Speedy

The PANTHER Classification System

More...PANTHERi		PTHR31156, PTHR31156, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11357, Spy1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NLX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGQARPPF EEESPQPSTT VRSPEVVVDD EVPGPSAPWI DPSPQPQSLG 
        60         70         80         90        100
LKRKSEWSDE SEEELEEELE LERAPEPEDT WVVETLCGLK MKLKRKRASS 
       110        120        130        140        150
VLPEHHEAFN RLLGDPVVQK FLAWDKDLRV SDKYLLAMVI AYFSRAGLFS 
       160        170        180        190        200
WQYQRIHFFL ALYLASDMEE DNQAPKQDIF SFLYGKNYSQ RPLFHKLRYQ 
       210        220        230 
LLCSMRWRTW VSPEEMEEIQ AYDPEHWVWA RDRTLIS
Length:237
Mass (Da):27,806
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAE6F98061C6FCCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT05J3KT05_HUMAN
Speedy protein E4
SPDYE4
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR45J3QR45_HUMAN
Speedy protein E4
SPDYE4
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC009451 Genomic DNA No translation available.
BC146949 mRNA Translation: AAI46950.1
BC146966 mRNA Translation: AAI46967.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45609.1

NCBI Reference Sequences

More...RefSeqi		NP_001121548.1, NM_001128076.1
XP_005256689.1, XM_005256632.4
XP_005256690.1, XM_005256633.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328794.10; ENSP00000329522.6; ENSG00000183318.12
ENST00000688021.1; ENSP00000510287.1; ENSG00000183318.12
ENST00000689094.1; ENSP00000509506.1; ENSG00000183318.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388333

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388333

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000689094.1; ENSP00000509506.1; NM_001394956.1; NP_001381885.1

UCSC genome browser

More...UCSCi		uc010cnz.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009451 Genomic DNA No translation available.
BC146949 mRNA Translation: AAI46950.1
BC146966 mRNA Translation: AAI46967.1
CCDSiCCDS45609.1
RefSeqiNP_001121548.1, NM_001128076.1
XP_005256689.1, XM_005256632.4
XP_005256690.1, XM_005256633.4

3D structure databases

AlphaFoldDBiA6NLX3
SMRiA6NLX3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132645, 11 interactors
IntActiA6NLX3, 60 interactors
STRINGi9606.ENSP00000329522

PTM databases

iPTMnetiA6NLX3
PhosphoSitePlusiA6NLX3

Genetic variation databases

BioMutaiSPDYE4

Proteomic databases

PaxDbiA6NLX3
PeptideAtlasiA6NLX3
PRIDEiA6NLX3
ProteomicsDBi1497

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6244, 8 antibodies from 7 providers

The DNASU plasmid repository

More...DNASUi		388333

Genome annotation databases

EnsembliENST00000328794.10; ENSP00000329522.6; ENSG00000183318.12
ENST00000688021.1; ENSP00000510287.1; ENSG00000183318.12
ENST00000689094.1; ENSP00000509506.1; ENSG00000183318.12
GeneIDi388333
KEGGihsa:388333
MANE-SelectiENST00000689094.1; ENSP00000509506.1; NM_001394956.1; NP_001381885.1
UCSCiuc010cnz.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388333

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPDYE4
HGNCiHGNC:35463, SPDYE4
HPAiENSG00000183318, Tissue enriched (testis)
MIMi617628, gene
neXtProtiNX_A6NLX3
PharmGKBiPA164726235
VEuPathDBiHostDB:ENSG00000183318

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SSQN, Eukaryota
GeneTreeiENSGT00940000154173
HOGENOMiCLU_070353_3_0_1
InParanoidiA6NLX3
OMAiLLCSMRW
OrthoDBi1480540at2759
PhylomeDBiA6NLX3
TreeFamiTF329827

Enzyme and pathway databases

PathwayCommonsiA6NLX3
SignaLinkiA6NLX3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		388333, 11 hits in 1058 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		388333
PharosiA6NLX3, Tdark

Protein Ontology

More...PROi		PR:A6NLX3
RNActiA6NLX3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183318, Expressed in testis and 51 other tissues
ExpressionAtlasiA6NLX3, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR020984, Speedy
PANTHERiPTHR31156, PTHR31156, 1 hit
PfamiView protein in Pfam
PF11357, Spy1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPDE4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NLX3
Secondary accession number(s): B2RUZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 25, 2022
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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