UniProtKB - A6NLX3 (SPDE4_HUMAN)

BLAST

>sp|A6NLX3|SPDE4_HUMAN Speedy protein E4 OS=Homo sapiens OX=9606 GN=SPDYE4 PE=2 SV=2
MASGQARPPFEEESPQPSTTVRSPEVVVDDEVPGPSAPWIDPSPQPQSLGLKRKSEWSDE
SEEELEEELELERAPEPEDTWVVETLCGLKMKLKRKRASSVLPEHHEAFNRLLGDPVVQK
FLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFLALYLASDMEEDNQAPKQDIF
SFLYGKNYSQRPLFHKLRYQLLCSMRWRTWVSPEEMEEIQAYDPEHWVWARDRTLIS

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History
Entry version 71 (07 Nov 2018)
Sequence version 2 (02 Sep 2008)
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Protein

Speedy protein E4

Gene

SPDYE4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Speedy protein E4
Gene namesⁱ	Name:SPDYE4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183318.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:35463 SPDYE4
MIMⁱ	617628 gene
neXtProtⁱ	NX_A6NLX3

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA164726235

PharmGKBⁱ

PA164726235

Polymorphism and mutation databases

BioMutaⁱ	SPDYE4

BioMutaⁱ

SPDYE4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000349195	1 – 237	Speedy protein E4Add BLAST		237

Proteomic databases

PaxDbⁱ	A6NLX3
PRIDEⁱ	A6NLX3
ProteomicsDBⁱ	1497

PTM databases

iPTMnetⁱ	A6NLX3
PhosphoSitePlusⁱ	A6NLX3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000183318 Expressed in 41 organ(s), highest expression level in testis
ExpressionAtlasⁱ	A6NLX3 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA025704 HPA051750

HPAⁱ

HPA025704
HPA051750

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	A6NLX3, 11 interactors
STRINGⁱ	9606.ENSP00000329522

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NLX3
SMRⁱ	A6NLX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IX6P Eukaryota ENOG41119TB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00420000029723
HOGENOMⁱ	HOG000132466
InParanoidⁱ	A6NLX3
KEGG Orthology (KO) More...KOⁱ	K08694
OMAⁱ	LLCSMRW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MC6
PhylomeDBⁱ	A6NLX3
TreeFamⁱ	TF329827

Family and domain databases

InterProⁱ	View protein in InterPro IPR020984 Speedy
PANTHERⁱ	PTHR31156 PTHR31156, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11357 Spy1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

A6NLX3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MASGQARPPF EEESPQPSTT VRSPEVVVDD EVPGPSAPWI DPSPQPQSLG 
        60         70         80         90        100
LKRKSEWSDE SEEELEEELE LERAPEPEDT WVVETLCGLK MKLKRKRASS 
       110        120        130        140        150
VLPEHHEAFN RLLGDPVVQK FLAWDKDLRV SDKYLLAMVI AYFSRAGLFS 
       160        170        180        190        200
WQYQRIHFFL ALYLASDMEE DNQAPKQDIF SFLYGKNYSQ RPLFHKLRYQ 
       210        220        230 
LLCSMRWRTW VSPEEMEEIQ AYDPEHWVWA RDRTLIS

Length:237

Mass (Da):27,806

Last modified:September 2, 2008 - v2

Checksum:ⁱFAE6F98061C6FCCF

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KT05	J3KT05_HUMAN	Speedy protein E4 Speedy protein E4	SPDYE4	91	Annotation score:
J3QR45	J3QR45_HUMAN	Speedy protein E4 Speedy protein E4	SPDYE4	41	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009451 Genomic DNA No translation available. BC146949 mRNA Translation: AAI46950.1 BC146966 mRNA Translation: AAI46967.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45609.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001121548.1, NM_001128076.1 XP_005256689.1, XM_005256632.4 XP_005256690.1, XM_005256633.4
UniGeneⁱ	Hs.230205 Hs.368429

Genome annotation databases

Ensemblⁱ	ENST00000328794; ENSP00000329522; ENSG00000183318
GeneIDⁱ	388333
KEGGⁱ	hsa:388333
UCSC genome browser More...UCSCⁱ	uc010cnz.1 human

Protein	Similar proteins		Species	Score	Length	Source
A6NLX3	SPDYE4 isoform 1		PANTR		237	UniRef90_A6NLX3
Uncharacterized protein		MACMU		237
Putative Speedy protein E4		MACFA		237
Uncharacterized protein		RHIRO		237
Uncharacterized protein		RHIBE		237
+12

Protein	Similar proteins		Species	Score	Length	Source
A6NLX3	Speedy/RINGO cell cycle regulator family member E4		GORGO		237	UniRef50_A6NLX3
Uncharacterized protein		CHLSB		237
Uncharacterized protein		RHIRO		237
Uncharacterized protein		RHIBE		237
Uncharacterized protein		MANLE		237
+26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009451 Genomic DNA No translation available. BC146949 mRNA Translation: AAI46950.1 BC146966 mRNA Translation: AAI46967.1
CCDSⁱ	CCDS45609.1
RefSeqⁱ	NP_001121548.1, NM_001128076.1 XP_005256689.1, XM_005256632.4 XP_005256690.1, XM_005256633.4
UniGeneⁱ	Hs.230205 Hs.368429

3D structure databases

ProteinModelPortalⁱ	A6NLX3
SMRⁱ	A6NLX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	A6NLX3, 11 interactors
STRINGⁱ	9606.ENSP00000329522

PTM databases

iPTMnetⁱ	A6NLX3
PhosphoSitePlusⁱ	A6NLX3

Polymorphism and mutation databases

BioMutaⁱ	SPDYE4

BioMutaⁱ

SPDYE4

Proteomic databases

PaxDbⁱ	A6NLX3
PRIDEⁱ	A6NLX3
ProteomicsDBⁱ	1497

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328794; ENSP00000329522; ENSG00000183318
GeneIDⁱ	388333
KEGGⁱ	hsa:388333
UCSCⁱ	uc010cnz.1 human

Organism-specific databases

CTDⁱ	388333
EuPathDBⁱ	HostDB:ENSG00000183318.11
GeneCardsⁱ	SPDYE4
HGNCⁱ	HGNC:35463 SPDYE4
HPAⁱ	HPA025704 HPA051750
MIMⁱ	617628 gene
neXtProtⁱ	NX_A6NLX3
PharmGKBⁱ	PA164726235
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IX6P Eukaryota ENOG41119TB LUCA
GeneTreeⁱ	ENSGT00420000029723
HOGENOMⁱ	HOG000132466
InParanoidⁱ	A6NLX3
KOⁱ	K08694
OMAⁱ	LLCSMRW
OrthoDBⁱ	EOG091G0MC6
PhylomeDBⁱ	A6NLX3
TreeFamⁱ	TF329827

Miscellaneous databases

GenomeRNAiⁱ	388333
Protein Ontology More...PROⁱ	PR:A6NLX3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183318 Expressed in 41 organ(s), highest expression level in testis
ExpressionAtlasⁱ	A6NLX3 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR020984 Speedy
PANTHERⁱ	PTHR31156 PTHR31156, 1 hit
Pfamⁱ	View protein in Pfam PF11357 Spy1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPDE4_HUMAN
Accessionⁱ	A6NLX3Primary (citable) accession number: A6NLX3 Secondary accession number(s): B2RUZ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	September 2, 2008
	Last modified:	November 7, 2018
	This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6NLX3 (SPDE4_HUMAN)

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Speedy protein E4

SPDYE4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ