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Protein

Speedy protein E4

Gene

SPDYE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • protein kinase binding Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Speedy protein E4
Gene namesi
Name:SPDYE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000183318.11
HGNCiHGNC:35463 SPDYE4
MIMi617628 gene
neXtProtiNX_A6NLX3

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726235

Polymorphism and mutation databases

BioMutaiSPDYE4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491951 – 237Speedy protein E4Add BLAST237

Proteomic databases

PaxDbiA6NLX3
PRIDEiA6NLX3
ProteomicsDBi1497

PTM databases

iPTMnetiA6NLX3
PhosphoSitePlusiA6NLX3

Expressioni

Gene expression databases

BgeeiENSG00000183318 Expressed in 41 organ(s), highest expression level in testis
ExpressionAtlasiA6NLX3 baseline and differential

Organism-specific databases

HPAiHPA025704
HPA051750

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA6NLX3, 11 interactors
STRINGi9606.ENSP00000329522

Structurei

3D structure databases

ProteinModelPortaliA6NLX3
SMRiA6NLX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

eggNOGiENOG410IX6P Eukaryota
ENOG41119TB LUCA
GeneTreeiENSGT00420000029723
HOGENOMiHOG000132466
InParanoidiA6NLX3
KOiK08694
OMAiLLCSMRW
OrthoDBiEOG091G0MC6
PhylomeDBiA6NLX3
TreeFamiTF329827

Family and domain databases

InterProiView protein in InterPro
IPR020984 Speedy
PANTHERiPTHR31156 PTHR31156, 1 hit
PfamiView protein in Pfam
PF11357 Spy1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NLX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGQARPPF EEESPQPSTT VRSPEVVVDD EVPGPSAPWI DPSPQPQSLG
60 70 80 90 100
LKRKSEWSDE SEEELEEELE LERAPEPEDT WVVETLCGLK MKLKRKRASS
110 120 130 140 150
VLPEHHEAFN RLLGDPVVQK FLAWDKDLRV SDKYLLAMVI AYFSRAGLFS
160 170 180 190 200
WQYQRIHFFL ALYLASDMEE DNQAPKQDIF SFLYGKNYSQ RPLFHKLRYQ
210 220 230
LLCSMRWRTW VSPEEMEEIQ AYDPEHWVWA RDRTLIS
Length:237
Mass (Da):27,806
Last modified:September 2, 2008 - v2
Checksum:iFAE6F98061C6FCCF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT05J3KT05_HUMAN
Speedy protein E4
SPDYE4
91Annotation score:
J3QR45J3QR45_HUMAN
Speedy protein E4
SPDYE4
41Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009451 Genomic DNA No translation available.
BC146949 mRNA Translation: AAI46950.1
BC146966 mRNA Translation: AAI46967.1
CCDSiCCDS45609.1
RefSeqiNP_001121548.1, NM_001128076.1
XP_005256689.1, XM_005256632.4
XP_005256690.1, XM_005256633.4
UniGeneiHs.230205
Hs.368429

Genome annotation databases

EnsembliENST00000328794; ENSP00000329522; ENSG00000183318
GeneIDi388333
KEGGihsa:388333
UCSCiuc010cnz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009451 Genomic DNA No translation available.
BC146949 mRNA Translation: AAI46950.1
BC146966 mRNA Translation: AAI46967.1
CCDSiCCDS45609.1
RefSeqiNP_001121548.1, NM_001128076.1
XP_005256689.1, XM_005256632.4
XP_005256690.1, XM_005256633.4
UniGeneiHs.230205
Hs.368429

3D structure databases

ProteinModelPortaliA6NLX3
SMRiA6NLX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NLX3, 11 interactors
STRINGi9606.ENSP00000329522

PTM databases

iPTMnetiA6NLX3
PhosphoSitePlusiA6NLX3

Polymorphism and mutation databases

BioMutaiSPDYE4

Proteomic databases

PaxDbiA6NLX3
PRIDEiA6NLX3
ProteomicsDBi1497

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328794; ENSP00000329522; ENSG00000183318
GeneIDi388333
KEGGihsa:388333
UCSCiuc010cnz.1 human

Organism-specific databases

CTDi388333
EuPathDBiHostDB:ENSG00000183318.11
GeneCardsiSPDYE4
HGNCiHGNC:35463 SPDYE4
HPAiHPA025704
HPA051750
MIMi617628 gene
neXtProtiNX_A6NLX3
PharmGKBiPA164726235
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX6P Eukaryota
ENOG41119TB LUCA
GeneTreeiENSGT00420000029723
HOGENOMiHOG000132466
InParanoidiA6NLX3
KOiK08694
OMAiLLCSMRW
OrthoDBiEOG091G0MC6
PhylomeDBiA6NLX3
TreeFamiTF329827

Miscellaneous databases

GenomeRNAii388333
PROiPR:A6NLX3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183318 Expressed in 41 organ(s), highest expression level in testis
ExpressionAtlasiA6NLX3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR020984 Speedy
PANTHERiPTHR31156 PTHR31156, 1 hit
PfamiView protein in Pfam
PF11357 Spy1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPDE4_HUMAN
AccessioniPrimary (citable) accession number: A6NLX3
Secondary accession number(s): B2RUZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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