UniProtKB - A6NLW8 (DUXA_HUMAN)
Protein
Double homeobox protein A
Gene
DUXA
Organism
Homo sapiens (Human)
Status
Functioni
Putative transcription factor.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 15 – 74 | Homeobox 1PROSITE-ProRule annotationAdd BLAST | 60 | |
DNA bindingi | 101 – 160 | Homeobox 2PROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Double homeobox protein A |
Gene namesi | Name:DUXA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000258873.2 |
HGNCi | HGNC:32179 DUXA |
MIMi | 611168 gene |
neXtProti | NX_A6NLW8 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000258873 |
PharmGKBi | PA142671924 |
Polymorphism and mutation databases
BioMutai | DUXA |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311327 | 1 – 204 | Double homeobox protein AAdd BLAST | 204 |
Proteomic databases
PaxDbi | A6NLW8 |
PRIDEi | A6NLW8 |
ProteomicsDBi | 1495 |
PTM databases
iPTMneti | A6NLW8 |
PhosphoSitePlusi | A6NLW8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000258873 Expressed in 13 organ(s), highest expression level in descending thoracic aorta |
Organism-specific databases
HPAi | HPA059358 |
Structurei
3D structure databases
ProteinModelPortali | A6NLW8 |
SMRi | A6NLW8 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
Homeobox, RepeatPhylogenomic databases
eggNOGi | KOG0849 Eukaryota ENOG410XS01 LUCA |
GeneTreei | ENSGT00940000163365 |
HOGENOMi | HOG000112297 |
InParanoidi | A6NLW8 |
OMAi | RCRTSYT |
OrthoDBi | 1580567at2759 |
PhylomeDBi | A6NLW8 |
TreeFami | TF340750 |
Family and domain databases
CDDi | cd00086 homeodomain, 2 hits |
InterProi | View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR000047 HTH_motif |
Pfami | View protein in Pfam PF00046 Homeodomain, 2 hits |
PRINTSi | PR00031 HTHREPRESSR |
SMARTi | View protein in SMART SM00389 HOX, 2 hits |
SUPFAMi | SSF46689 SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS50071 HOMEOBOX_2, 2 hits |
i Sequence
Sequence statusi: Complete.
A6NLW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEDTYSHKM VKTNHRRCRT KFTEEQLKIL INTFNQKPYP GYATKQKLAL
60 70 80 90 100
EINTEESRIQ IWFQNRRARH GFQKRPEAET LESSQSQGQD QPGVEFQSRE
110 120 130 140 150
ARRCRTTYSA SQLHTLIKAF MKNPYPGIDS REELAKEIGV PESRVQIWFQ
160 170 180 190 200
NRRSRLLLQR KREPVASLEQ EEQGKIPEGL QGAEDTQNGT NFTSDSHFSG
ARTW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025588 Genomic DNA No translation available. |
CCDSi | CCDS33126.1 |
RefSeqi | NP_001012747.1, NM_001012729.1 |
UniGenei | Hs.585857 |
Genome annotation databases
Ensembli | ENST00000554048; ENSP00000452398; ENSG00000258873 |
GeneIDi | 503835 |
KEGGi | hsa:503835 |
UCSCi | uc002qoa.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025588 Genomic DNA No translation available. |
CCDSi | CCDS33126.1 |
RefSeqi | NP_001012747.1, NM_001012729.1 |
UniGenei | Hs.585857 |
3D structure databases
ProteinModelPortali | A6NLW8 |
SMRi | A6NLW8 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000452398 |
PTM databases
iPTMneti | A6NLW8 |
PhosphoSitePlusi | A6NLW8 |
Polymorphism and mutation databases
BioMutai | DUXA |
Proteomic databases
PaxDbi | A6NLW8 |
PRIDEi | A6NLW8 |
ProteomicsDBi | 1495 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000554048; ENSP00000452398; ENSG00000258873 |
GeneIDi | 503835 |
KEGGi | hsa:503835 |
UCSCi | uc002qoa.2 human |
Organism-specific databases
CTDi | 503835 |
EuPathDBi | HostDB:ENSG00000258873.2 |
GeneCardsi | DUXA |
H-InvDBi | HIX0016200 |
HGNCi | HGNC:32179 DUXA |
HPAi | HPA059358 |
MIMi | 611168 gene |
neXtProti | NX_A6NLW8 |
OpenTargetsi | ENSG00000258873 |
PharmGKBi | PA142671924 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0849 Eukaryota ENOG410XS01 LUCA |
GeneTreei | ENSGT00940000163365 |
HOGENOMi | HOG000112297 |
InParanoidi | A6NLW8 |
OMAi | RCRTSYT |
OrthoDBi | 1580567at2759 |
PhylomeDBi | A6NLW8 |
TreeFami | TF340750 |
Miscellaneous databases
GenomeRNAii | 503835 |
PROi | PR:A6NLW8 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000258873 Expressed in 13 organ(s), highest expression level in descending thoracic aorta |
Family and domain databases
CDDi | cd00086 homeodomain, 2 hits |
InterProi | View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR000047 HTH_motif |
Pfami | View protein in Pfam PF00046 Homeodomain, 2 hits |
PRINTSi | PR00031 HTHREPRESSR |
SMARTi | View protein in SMART SM00389 HOX, 2 hits |
SUPFAMi | SSF46689 SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS50071 HOMEOBOX_2, 2 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | DUXA_HUMAN | |
Accessioni | A6NLW8Primary (citable) accession number: A6NLW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 13, 2019 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot