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Protein

Ret finger protein-like 4A

Gene

RFPL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 53RING-type; degeneratePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 4A
Alternative name(s):
RING finger protein 210
Gene namesi
Name:RFPL4A
Synonyms:RFPL4, RNF210
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000223638.3
HGNCiHGNC:16449 RFPL4A
MIMi612601 gene
neXtProtiNX_A6NLU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi342931
OpenTargetsiENSG00000223638
PharmGKBiPA162401186

Polymorphism and mutation databases

BioMutaiRFPL4A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008111 – 287Ret finger protein-like 4AAdd BLAST287

Proteomic databases

MaxQBiA6NLU0
PaxDbiA6NLU0
PRIDEiA6NLU0
ProteomicsDBi1492

PTM databases

iPTMnetiA6NLU0
PhosphoSitePlusiA6NLU0

Expressioni

Gene expression databases

BgeeiENSG00000223638 Expressed in 29 organ(s), highest expression level in right lobe of liver
CleanExiHS_RFPL4A

Organism-specific databases

HPAiHPA046368

Interactioni

Subunit structurei

Interacts with PSMB1, UBE2A and CCNB1.By similarity

Protein-protein interaction databases

BioGridi131211, 3 interactors
STRINGi9606.ENSP00000392936

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliA6NLU0
SMRiA6NLU0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA6NLU0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 276B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 53RING-type; degeneratePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118993
HOGENOMiHOG000230861
HOVERGENiHBG061854
InParanoidiA6NLU0
OMAiQTFLSIC
OrthoDBiEOG091G0G5I
PhylomeDBiA6NLU0
TreeFamiTF317532

Family and domain databases

CDDicd15821 SPRY_PRY_RFPL, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR022723 RDM_domain_RFPL
IPR038908 RFPL
IPR037960 SPRY/PRY_RFPL
IPR003877 SPRY_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25462 PTHR25462, 1 hit
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF11002 RDM, 1 hit
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NLU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR
60 70 80 90 100
FCSVVSQKDD IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF
110 120 130 140 150
DVDTANNYLI ISEDLRSFRS GDLSQNRKEQ AERFDTALCV LGTPRFTSGR
160 170 180 190 200
HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL SSEHGFLTVG CREGKVFAAS
210 220 230 240 250
TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT FIEIPVCEPW
260 270 280
RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK
Length:287
Mass (Da):32,238
Last modified:June 15, 2010 - v3
Checksum:i53B423A78E3F3E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008749 Genomic DNA No translation available.
CCDSiCCDS46201.1
RefSeqiNP_001138486.1, NM_001145014.1
UniGeneiHs.631553

Genome annotation databases

EnsembliENST00000434937; ENSP00000392936; ENSG00000223638
GeneIDi342931
KEGGihsa:342931
UCSCiuc010yge.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008749 Genomic DNA No translation available.
CCDSiCCDS46201.1
RefSeqiNP_001138486.1, NM_001145014.1
UniGeneiHs.631553

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBEX-ray2.52A/B/C/D94-287[»]
ProteinModelPortaliA6NLU0
SMRiA6NLU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131211, 3 interactors
STRINGi9606.ENSP00000392936

PTM databases

iPTMnetiA6NLU0
PhosphoSitePlusiA6NLU0

Polymorphism and mutation databases

BioMutaiRFPL4A

Proteomic databases

MaxQBiA6NLU0
PaxDbiA6NLU0
PRIDEiA6NLU0
ProteomicsDBi1492

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434937; ENSP00000392936; ENSG00000223638
GeneIDi342931
KEGGihsa:342931
UCSCiuc010yge.3 human

Organism-specific databases

CTDi342931
DisGeNETi342931
EuPathDBiHostDB:ENSG00000223638.3
GeneCardsiRFPL4A
HGNCiHGNC:16449 RFPL4A
HPAiHPA046368
MIMi612601 gene
neXtProtiNX_A6NLU0
OpenTargetsiENSG00000223638
PharmGKBiPA162401186
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118993
HOGENOMiHOG000230861
HOVERGENiHBG061854
InParanoidiA6NLU0
OMAiQTFLSIC
OrthoDBiEOG091G0G5I
PhylomeDBiA6NLU0
TreeFamiTF317532

Miscellaneous databases

EvolutionaryTraceiA6NLU0
GenomeRNAii342931
PROiPR:A6NLU0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000223638 Expressed in 29 organ(s), highest expression level in right lobe of liver
CleanExiHS_RFPL4A

Family and domain databases

CDDicd15821 SPRY_PRY_RFPL, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR022723 RDM_domain_RFPL
IPR038908 RFPL
IPR037960 SPRY/PRY_RFPL
IPR003877 SPRY_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25462 PTHR25462, 1 hit
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF11002 RDM, 1 hit
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFPLA_HUMAN
AccessioniPrimary (citable) accession number: A6NLU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 15, 2010
Last modified: September 12, 2018
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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