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Protein

Small integral membrane protein 23

Gene

SMIM23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 23
Gene namesi
Name:SMIM23
Synonyms:C5orf50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000185662.8
HGNCiHGNC:34440 SMIM23
neXtProtiNX_A6NLE4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 53Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini54 – 172ExtracellularSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003412371 – 172Small integral membrane protein 23Add BLAST172

Proteomic databases

PaxDbiA6NLE4
PRIDEiA6NLE4
ProteomicsDBi1469

Expressioni

Gene expression databases

BgeeiENSG00000185662 Expressed in 49 organ(s), highest expression level in right testis
CleanExiHS_C5orf50
ExpressionAtlasiA6NLE4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331214

Structurei

3D structure databases

SMRiA6NLE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 128Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1DG Eukaryota
ENOG41117EA LUCA
GeneTreeiENSGT00390000017300
HOGENOMiHOG000111519
HOVERGENiHBG107641
InParanoidiA6NLE4
OrthoDBiEOG091G13CI
TreeFamiTF338699

Family and domain databases

InterProiView protein in InterPro
IPR027880 DUF4635
PANTHERiPTHR37865 PTHR37865, 1 hit
PfamiView protein in Pfam
PF15466 DUF4635, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NLE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATQQVDSRR QVAAEQVAAQ LLERRRGSHC DDEKQTLLAL LILVLYLSTE
60 70 80 90 100
IWGSSWEVSE RIRECNYYQN LAVPQGLEYQ TNEPSEEPIK TIRNWLKEKL
110 120 130 140 150
HVFSEKLEEE VQQLEQLAWD LELWLDALLG EPHQEEHCST YKSHLWEWAW
160 170
ALGREHKGGE GLLEISLSGA EL
Length:172
Mass (Da):20,025
Last modified:September 7, 2016 - v3
Checksum:i40CB2BCB063CB240
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC34H0YC34_HUMAN
Small integral membrane protein 23
SMIM23
172Annotation score:
A0A1X7SBS2A0A1X7SBS2_HUMAN
Small integral membrane protein 23
SMIM23
156Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05773636T → M. Corresponds to variant dbSNP:rs10037031Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011410 Genomic DNA No translation available.
DN930602 mRNA No translation available.
EG327839 mRNA No translation available.
CCDSiCCDS87347.1
RefSeqiNP_001276899.1, NM_001289970.1
UniGeneiHs.591740

Genome annotation databases

EnsembliENST00000523047; ENSP00000430818; ENSG00000185662
ENST00000639838; ENSP00000490990; ENSG00000185662
GeneIDi644994
KEGGihsa:644994
UCSCiuc063jql.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011410 Genomic DNA No translation available.
DN930602 mRNA No translation available.
EG327839 mRNA No translation available.
CCDSiCCDS87347.1
RefSeqiNP_001276899.1, NM_001289970.1
UniGeneiHs.591740

3D structure databases

SMRiA6NLE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331214

Proteomic databases

PaxDbiA6NLE4
PRIDEiA6NLE4
ProteomicsDBi1469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523047; ENSP00000430818; ENSG00000185662
ENST00000639838; ENSP00000490990; ENSG00000185662
GeneIDi644994
KEGGihsa:644994
UCSCiuc063jql.1 human

Organism-specific databases

CTDi644994
EuPathDBiHostDB:ENSG00000185662.8
GeneCardsiSMIM23
HGNCiHGNC:34440 SMIM23
neXtProtiNX_A6NLE4
OpenTargetsiENSG00000185662
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1DG Eukaryota
ENOG41117EA LUCA
GeneTreeiENSGT00390000017300
HOGENOMiHOG000111519
HOVERGENiHBG107641
InParanoidiA6NLE4
OrthoDBiEOG091G13CI
TreeFamiTF338699

Miscellaneous databases

PROiPR:A6NLE4

Gene expression databases

BgeeiENSG00000185662 Expressed in 49 organ(s), highest expression level in right testis
CleanExiHS_C5orf50
ExpressionAtlasiA6NLE4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027880 DUF4635
PANTHERiPTHR37865 PTHR37865, 1 hit
PfamiView protein in Pfam
PF15466 DUF4635, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIM23_HUMAN
AccessioniPrimary (citable) accession number: A6NLE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 7, 2016
Last modified: September 12, 2018
This is version 70 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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