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Entry version 74 (13 Feb 2019)
Sequence version 1 (24 Jul 2007)
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Protein

UPF0524 protein C3orf70

Gene

C3orf70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0524 protein C3orf70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C3orf70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000187068.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33731 C3orf70

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NLC5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
285382

Open Targets

More...
OpenTargetsi
ENSG00000187068

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379707

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C3orf70

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003199761 – 250UPF0524 protein C3orf70Add BLAST250

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
A6NLC5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A6NLC5

PRoteomics IDEntifications database

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PRIDEi
A6NLC5

ProteomicsDB human proteome resource

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ProteomicsDBi
1464

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NLC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A6NLC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187068 Expressed in 187 organ(s), highest expression level in forebrain

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A6NLC5 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041861

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
130098, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A6NLC5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A6NLC5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0524 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGTG Eukaryota
ENOG410XQHJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006618

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000043069

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG095343

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NLC5

Identification of Orthologs from Complete Genome Data

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OMAi
YMESCDE

Database of Orthologous Groups

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OrthoDBi
1244564at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NLC5

TreeFam database of animal gene trees

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TreeFami
TF328625

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029670 UPF0524_fam

The PANTHER Classification System

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PANTHERi
PTHR31785 PTHR31785, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15823 UPF0524, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NLC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAASPASE RGWKSEKLDE AQALARSCAA RRPDFQPCDG LSICATHSHG
60 70 80 90 100
KCFKLHWCCH LGWCHCKYMY QPMTPVEQLP STEIPARPRE PTNTIQISVS
110 120 130 140 150
LTEHFLKFAS VFQPPLPPDS PRYCMISDLF IDNYQVKCIN GKMCYVQKQP
160 170 180 190 200
APHSHRMSPE EVSAHDALIS KESNTPKIDH CSSPSSSEDS GINAIGAHYV
210 220 230 240 250
ESCDEDTEEG AELSSEEDYS PESSWEPDEC TLLSPSQSDL EVIETIETTV
Length:250
Mass (Da):27,769
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B2930FDE8905AC3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC025573 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78232.1
BC137178 mRNA Translation: AAI37179.1
BC137179 mRNA Translation: AAI37180.1
BC150565 mRNA Translation: AAI50566.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33900.1

NCBI Reference Sequences

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RefSeqi
NP_001020437.1, NM_001025266.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.245793
Hs.380048

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335012; ENSP00000334974; ENSG00000187068

Database of genes from NCBI RefSeq genomes

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GeneIDi
285382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285382

UCSC genome browser

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UCSCi
uc003fpd.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025573 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78232.1
BC137178 mRNA Translation: AAI37179.1
BC137179 mRNA Translation: AAI37180.1
BC150565 mRNA Translation: AAI50566.1
CCDSiCCDS33900.1
RefSeqiNP_001020437.1, NM_001025266.1
UniGeneiHs.245793
Hs.380048

3D structure databases

ProteinModelPortaliA6NLC5
SMRiA6NLC5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130098, 1 interactor

PTM databases

iPTMnetiA6NLC5
PhosphoSitePlusiA6NLC5

Polymorphism and mutation databases

BioMutaiC3orf70

Proteomic databases

MaxQBiA6NLC5
PaxDbiA6NLC5
PRIDEiA6NLC5
ProteomicsDBi1464

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335012; ENSP00000334974; ENSG00000187068
GeneIDi285382
KEGGihsa:285382
UCSCiuc003fpd.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285382
DisGeNETi285382
EuPathDBiHostDB:ENSG00000187068.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C3orf70
HGNCiHGNC:33731 C3orf70
HPAiHPA041861
neXtProtiNX_A6NLC5
OpenTargetsiENSG00000187068
PharmGKBiPA162379707

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGTG Eukaryota
ENOG410XQHJ LUCA
GeneTreeiENSGT00390000006618
HOGENOMiHOG000043069
HOVERGENiHBG095343
InParanoidiA6NLC5
OMAiYMESCDE
OrthoDBi1244564at2759
PhylomeDBiA6NLC5
TreeFamiTF328625

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C3orf70 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
285382

Protein Ontology

More...
PROi
PR:A6NLC5

Gene expression databases

BgeeiENSG00000187068 Expressed in 187 organ(s), highest expression level in forebrain
GenevisibleiA6NLC5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029670 UPF0524_fam
PANTHERiPTHR31785 PTHR31785, 1 hit
PfamiView protein in Pfam
PF15823 UPF0524, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC070_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NLC5
Secondary accession number(s): B2RNY2, B9EH83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: February 13, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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