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Protein

Olfactory receptor 5B21

Gene

OR5B21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B21
Gene namesi
Name:OR5B21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000198283.2
HGNCiHGNC:19616 OR5B21
neXtProtiNX_A6NL26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 95ExtracellularSequence analysisAdd BLAST19
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 137CytoplasmicSequence analysisAdd BLAST21
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 199ExtracellularSequence analysisAdd BLAST41
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 235CytoplasmicSequence analysisAdd BLAST15
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 270ExtracellularSequence analysisAdd BLAST14
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 309CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198283
PharmGKBiPA134867164

Polymorphism and mutation databases

BioMutaiOR5B21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104741 – 309Olfactory receptor 5B21Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NL26
PRIDEiA6NL26
ProteomicsDBi1445

PTM databases

iPTMnetiA6NL26
PhosphoSitePlusiA6NL26

Expressioni

Gene expression databases

BgeeiENSG00000198283 Expressed in 3 organ(s), highest expression level in left testis
CleanExiHS_OR5B21

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353537

Structurei

3D structure databases

ProteinModelPortaliA6NL26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUX Eukaryota
ENOG41117FD LUCA
GeneTreeiENSGT00890000139366
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NL26
KOiK04257
OMAiFIYIAIQ
OrthoDBiEOG091G0AZH
PhylomeDBiA6NL26
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NL26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSTEVTEF ILLGLTDDPN LQIPLLLAFL FIYLITLLGN GGMMVIIHSD
60 70 80 90 100
SHLHTPMYFF LSNLSLVDLG YSSAVAPKTV AALRSGDKAI SYDGCAAQFF
110 120 130 140 150
FFVGFATVEC YLLASMAYDR HAAVCRPLHY TTTMTAGVCA LLATGSYVSG
160 170 180 190 200
FLNASIHAAG TFRLSFCGSN EINHFFCDIP PLLALSCSDT RISKLVVFVA
210 220 230 240 250
GFNVFFTLLV ILISYFFICI TIQRMHSAEG QKKVFSTCAS HLTALSIFYG
260 270 280 290 300
TIIFMYLQPN SSQSVDTDKI ASVFYTVVIP MLNPLIYSLR NKEVKSALWK

ILNKLYPQY
Length:309
Mass (Da):34,174
Last modified:July 24, 2007 - v1
Checksum:i5AAA162D09AC8BA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062041272S → Y. Corresponds to variant dbSNP:rs58454093Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003557 Genomic DNA No translation available.
CCDSiCCDS31552.1
RefSeqiNP_001005218.1, NM_001005218.1
UniGeneiHs.553647

Genome annotation databases

EnsembliENST00000360374; ENSP00000353537; ENSG00000198283
GeneIDi219968
KEGGihsa:219968
UCSCiuc010rki.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003557 Genomic DNA No translation available.
CCDSiCCDS31552.1
RefSeqiNP_001005218.1, NM_001005218.1
UniGeneiHs.553647

3D structure databases

ProteinModelPortaliA6NL26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353537

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NL26
PhosphoSitePlusiA6NL26

Polymorphism and mutation databases

BioMutaiOR5B21

Proteomic databases

PaxDbiA6NL26
PRIDEiA6NL26
ProteomicsDBi1445

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360374; ENSP00000353537; ENSG00000198283
GeneIDi219968
KEGGihsa:219968
UCSCiuc010rki.3 human

Organism-specific databases

CTDi219968
EuPathDBiHostDB:ENSG00000198283.2
GeneCardsiOR5B21
HGNCiHGNC:19616 OR5B21
neXtProtiNX_A6NL26
OpenTargetsiENSG00000198283
PharmGKBiPA134867164
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUX Eukaryota
ENOG41117FD LUCA
GeneTreeiENSGT00890000139366
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NL26
KOiK04257
OMAiFIYIAIQ
OrthoDBiEOG091G0AZH
PhylomeDBiA6NL26
TreeFamiTF352753

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii219968
PROiPR:A6NL26

Gene expression databases

BgeeiENSG00000198283 Expressed in 3 organ(s), highest expression level in left testis
CleanExiHS_OR5B21

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR5BL_HUMAN
AccessioniPrimary (citable) accession number: A6NL26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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