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Protein

Putative solute carrier family 22 member 31

Gene

SLC22A31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Organic anion transporter that mediates the uptake of ions.Curated

GO - Molecular functioni

Keywordsi

Biological processIon transport, Transport

Protein family/group databases

TCDBi2.A.1.19.23 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Putative solute carrier family 22 member 31Curated
Gene namesi
Name:SLC22A31Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000259803.6
HGNCiHGNC:27091 SLC22A31
neXtProtiNX_A6NKX4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicCuratedAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 128ExtracellularCuratedAdd BLAST84
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 157CytoplasmicCurated8
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 182ExtracellularCurated4
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 218CytoplasmicCuratedAdd BLAST15
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 246ExtracellularCurated7
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 339CytoplasmicCuratedAdd BLAST72
Transmembranei340 – 357HelicalSequence analysisAdd BLAST18
Topological domaini358 – 366ExtracellularCurated9
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 395CytoplasmicCurated8
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 420ExtracellularCurated4
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 448CytoplasmicCurated7
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 483ExtracellularCuratedAdd BLAST14
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 556CytoplasmicCuratedAdd BLAST52

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000259803

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330311 – 556Putative solute carrier family 22 member 31Add BLAST556

Proteomic databases

PRIDEiA6NKX4
ProteomicsDBi1436

PTM databases

iPTMnetiA6NKX4
PhosphoSitePlusiA6NKX4

Expressioni

Gene expression databases

BgeeiENSG00000259803

Structurei

3D structure databases

ProteinModelPortaliA6NKX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi164 – 541Leu-richPROSITE-ProRule annotationAdd BLAST378

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000014377
HOGENOMiHOG000015298
HOVERGENiHBG108438
InParanoidiA6NKX4
OMAiPCWLLAT
OrthoDBiEOG091G0L8L
PhylomeDBiA6NKX4

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

A6NKX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQEARVLRA AGGFGRARRL LASASWVPCI VLGLVLSSEE LLTAQPAPHC
60 70 80 90 100
RPDPTLLPPA LRALRGPALL DAAIPRLGPT RAPAEALGVL SPSYLAPLTR
110 120 130 140 150
APRPSSWASC SGAAAGPTWN LVCGDGWKVP LEQVSHLLGW LLGCVILGAG
160 170 180 190 200
CDRFGRRAVF VASLVLTTGL GASEALAASF PTLLVLRLLH GGTLAGALLA
210 220 230 240 250
LYLARLELCD PPHRLAFSMG AGLFSVVGTL LLPGLAALVQ DWRLLQGLGA
260 270 280 290 300
LMSGLLLLFW GFPALFPESP CWLLATGQVA RARKILWRFA EASGVGPGDS
310 320 330 340 350
SLEENSLATE LTMLSARSPQ PRYHSPLGLL RTRVTWRNGL ILGFSSLVGG
360 370 380 390 400
GIRASFRRSL APQVPTFYLP YFLEAGLEAA ALVFLLLTAD CCGRRPVLLL
410 420 430 440 450
GTMVTGLASL LLLAGAQYLP GWTVLFLSVL GLLASRAVSA LSSLFAAEVF
460 470 480 490 500
PTVIRGAGLG LVLGAGFLGQ AAGPLDTLHG RQGFFLQQVV FASLAVLALL
510 520 530 540 550
CVLLLPESRS RGLPQSLQDA DRLRRSPLLR GRPRQDHLPL LPPSNSYWAG

HTPEQH
Length:556
Mass (Da):58,815
Last modified:March 28, 2018 - v4
Checksum:iAAE24E82A711AD14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009113 Genomic DNA No translation available.
UniGeneiHs.447544
Hs.743726

Genome annotation databases

EnsembliENST00000562855; ENSP00000474621; ENSG00000259803

Similar proteinsi

Entry informationi

Entry nameiS22AV_HUMAN
AccessioniPrimary (citable) accession number: A6NKX4
Secondary accession number(s): S4R3Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 81 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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