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Protein

RanBP2-like and GRIP domain-containing protein 3

Gene

RGPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RanBP2-like and GRIP domain-containing protein 3
Gene namesi
Name:RGPD3
Synonyms:RGP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000153165.18
HGNCiHGNC:32416 RGPD3
MIMi612706 gene
neXtProtiNX_A6NKT7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671072

Polymorphism and mutation databases

BioMutaiRGPD3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003406661 – 1758RanBP2-like and GRIP domain-containing protein 3Add BLAST1758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NKT7
MaxQBiA6NKT7
PaxDbiA6NKT7
PRIDEiA6NKT7
ProteomicsDBi1430

PTM databases

iPTMnetiA6NKT7
PhosphoSitePlusiA6NKT7

Expressioni

Gene expression databases

BgeeiENSG00000153165 Expressed in 42 organ(s), highest expression level in testis
CleanExiHS_RGPD3
ExpressionAtlasiA6NKT7 baseline and differential
GenevisibleiA6NKT7 HS

Organism-specific databases

HPAiHPA049497
HPA051675
HPA067564

Interactioni

Protein-protein interaction databases

BioGridi575821, 16 interactors
IntActiA6NKT7, 6 interactors
MINTiA6NKT7
STRINGi9606.ENSP00000386588

Structurei

3D structure databases

ProteinModelPortaliA6NKT7
SMRiA6NKT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 93TPR 1Add BLAST34
Repeati584 – 617TPR 2Add BLAST34
Domaini1037 – 1173RanBD1 1PROSITE-ProRule annotationAdd BLAST137
Domaini1334 – 1470RanBD1 2PROSITE-ProRule annotationAdd BLAST137
Domaini1703 – 1753GRIPPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili176 – 229Sequence analysisAdd BLAST54
Coiled coili805 – 837Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1262 – 1267Poly-Ser6

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
COG5171 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000089994
HOVERGENiHBG108404
InParanoidiA6NKT7
KOiK12172
PhylomeDBiA6NKT7
TreeFamiTF314797

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
PF00638 Ran_BP1, 2 hits
SMARTiView protein in SMART
SM00755 Grip, 1 hit
SM00160 RanBD, 2 hits
SM00028 TPR, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
PS50196 RANBD1, 2 hits
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6NKT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC
60 70 80 90 100
TYINVREMDP RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAEYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL
160 170 180 190 200
FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVARCHE AERNIALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR
260 270 280 290 300
DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK
310 320 330 340 350
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD
360 370 380 390 400
RLSQSGHMLL NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS
410 420 430 440 450
FLGSDDIGNI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA
460 470 480 490 500
LPGIRKWLKQ LFHHLPQETS RLETNAPESI CILDLEVFLL GVVYTSHLQL
510 520 530 540 550
KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI HRKAVPGNSA
560 570 580 590 600
KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI
610 620 630 640 650
GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED
660 670 680 690 700
AHVTFAILDA VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL
710 720 730 740 750
SPEEQEECKN YLRKTRGYLI KILDDSDSNL SVVKKLPVPL ESVKEMLKSV
760 770 780 790 800
MQELENYSEG GPLYKNGSLR NADSEIKHST PSPTKYSLSP SKSYKYSPKT
810 820 830 840 850
PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH RWPTENYGPD
860 870 880 890 900
SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK
910 920 930 940 950
GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKKSEKP LENDTGLQAQ
960 970 980 990 1000
DISGRKKGRG VIFGQTSSTF TFADVAKSTS GEGFQFGKKD LNFKGFSGAG
1010 1020 1030 1040 1050
EKLFSSQYGK MANKANTSGD FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL
1060 1070 1080 1090 1100
VTGEEGEKVL YSQGVKLFRF DAEVSQWKER GLGNLKILKN EVNGKVRMLM
1110 1120 1130 1140 1150
QREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG DAKLERLAAK
1160 1170 1180 1190 1200
FKTPELAEEF KQKFEECQRL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS
1210 1220 1230 1240 1250
GLKDFKTFLT NDQTKVAEEE NKGSGTGAAG ASDTTIKPNA ENTGPTLEWD
1260 1270 1280 1290 1300
NYDLREDALD DSVSSSSVHA SPLASSPVRK NLFHFDESTT GSNFSFKSAL
1310 1320 1330 1340 1350
SLSKSPAKLN QSGTSVGTDE ESDVTQEEER DGQYFEPVVP LPDLVEVSSG
1360 1370 1380 1390 1400
EENEQVVFSH RAEFYRYDKD VGQWKERGIG DIKILQNYDN KHVRILMRRD
1410 1420 1430 1440 1450
QVLKLCANHR ITPDMSLQNM KGTERVWVWT ACDFADGERK VEHLAVRFKL
1460 1470 1480 1490 1500
QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET
1510 1520 1530 1540 1550
TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF
1560 1570 1580 1590 1600
SSEKSKPFAF GNSSATGSLF GFSFNAPLKS NNSETSSVAQ SGSESKVEPK
1610 1620 1630 1640 1650
KCELSKNSDI EQSSDSKVKN LSASFPTEES SINYTFKTPE KEPPLWYAEF
1660 1670 1680 1690 1700
TKEELVQKLS STTKSADHLN GLLREIEATN AVLMEQIKLL KSEIRRLERN
1710 1720 1730 1740 1750
QEQEVSAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML QLSLEEKGKL

AAVAQGEE
Length:1,758
Mass (Da):197,487
Last modified:March 8, 2011 - v2
Checksum:i76CCC1934CCD6E48
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNE0J3KNE0_HUMAN
RanBP2-like and GRIP domain-contain...
RGPD3
1,760Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097527 Genomic DNA No translation available.
AC114755 Genomic DNA No translation available.
CCDSiCCDS46379.1
RefSeqiNP_001137485.1, NM_001144013.1
UniGeneiHs.726367

Genome annotation databases

EnsembliENST00000409886; ENSP00000386588; ENSG00000153165
GeneIDi653489
KEGGihsa:653489
UCSCiuc010ywi.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097527 Genomic DNA No translation available.
AC114755 Genomic DNA No translation available.
CCDSiCCDS46379.1
RefSeqiNP_001137485.1, NM_001144013.1
UniGeneiHs.726367

3D structure databases

ProteinModelPortaliA6NKT7
SMRiA6NKT7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575821, 16 interactors
IntActiA6NKT7, 6 interactors
MINTiA6NKT7
STRINGi9606.ENSP00000386588

PTM databases

iPTMnetiA6NKT7
PhosphoSitePlusiA6NKT7

Polymorphism and mutation databases

BioMutaiRGPD3

Proteomic databases

EPDiA6NKT7
MaxQBiA6NKT7
PaxDbiA6NKT7
PRIDEiA6NKT7
ProteomicsDBi1430

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409886; ENSP00000386588; ENSG00000153165
GeneIDi653489
KEGGihsa:653489
UCSCiuc010ywi.2 human

Organism-specific databases

CTDi653489
EuPathDBiHostDB:ENSG00000153165.18
GeneCardsiRGPD3
H-InvDBiHIX0030036
HGNCiHGNC:32416 RGPD3
HPAiHPA049497
HPA051675
HPA067564
MIMi612706 gene
neXtProtiNX_A6NKT7
PharmGKBiPA142671072
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
COG5171 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000089994
HOVERGENiHBG108404
InParanoidiA6NKT7
KOiK12172
PhylomeDBiA6NKT7
TreeFamiTF314797

Miscellaneous databases

ChiTaRSiRGPD3 human
GenomeRNAii653489
PROiPR:A6NKT7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153165 Expressed in 42 organ(s), highest expression level in testis
CleanExiHS_RGPD3
ExpressionAtlasiA6NKT7 baseline and differential
GenevisibleiA6NKT7 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
PF00638 Ran_BP1, 2 hits
SMARTiView protein in SMART
SM00755 Grip, 1 hit
SM00160 RanBD, 2 hits
SM00028 TPR, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
PS50196 RANBD1, 2 hits
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGPD3_HUMAN
AccessioniPrimary (citable) accession number: A6NKT7
Secondary accession number(s): B8ZZM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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