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Protein

Choriogonadotropin subunit beta variant 1

Gene

CGB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.1 Publication

GO - Molecular functioni

  • hormone activity Source: AgBase

GO - Biological processi

  • hormone-mediated signaling pathway Source: GO_Central

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta variant 1
Gene namesi
Name:CGB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267631.4
HGNCiHGNC:16721 CGB1
MIMi608823 gene
neXtProtiNX_A6NKQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114335
OpenTargetsiENSG00000267631
PharmGKBiPA26435

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
ChainiPRO_000034254851 – 187Choriogonadotropin subunit beta variant 1Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 107By similarity
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 122By similarity
Disulfide bondi76 ↔ 160By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 138By similarity
Disulfide bondi88 ↔ 140By similarity
Disulfide bondi143 ↔ 150By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiA6NKQ9
PRIDEiA6NKQ9
ProteomicsDBi1426
1427 [A6NKQ9-2]

PTM databases

iPTMnetiA6NKQ9
PhosphoSitePlusiA6NKQ9

Expressioni

Tissue specificityi

Expressed in placenta, testis and pituitary.2 Publications

Gene expression databases

BgeeiENSG00000267631 Expressed in 35 organ(s), highest expression level in pituitary gland
CleanExiHS_CGB1
ExpressionAtlasiA6NKQ9 baseline and differential
GenevisibleiA6NKQ9 HS

Organism-specific databases

HPAiHPA038925
HPA038934

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125315, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA6NKQ9
SMRiA6NKQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOVERGENiHBG006698
InParanoidiA6NKQ9
KOiK10045
OrthoDBiEOG091G0XFH
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NKQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA
60 70 80 90 100
SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP
110 120 130 140 150
ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC
160 170 180
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGP
Length:187
Mass (Da):20,468
Last modified:July 1, 2008 - v3
Checksum:i1EB79D84CFA36ACA
GO
Isoform 2 (identifier: A6NKQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-35: MFQ → MSK

Show »
Length:155
Mass (Da):16,666
Checksum:i76F77A3681140D48
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R385S4R385_HUMAN
Uncharacterized protein
77Annotation score:
K7ELM3K7ELM3_HUMAN
Choriogonadotropin subunit beta var...
CGB1
129Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055838185P → S. Corresponds to variant dbSNP:rs35371968Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0344901 – 32Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_03449133 – 35MFQ → MSK in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52436.1
BC126460 mRNA Translation: AAI26461.1
CCDSiCCDS12751.2 [A6NKQ9-2]
RefSeqiNP_203695.2, NM_033377.1 [A6NKQ9-2]
UniGeneiHs.659014

Genome annotation databases

EnsembliENST00000301407; ENSP00000301407; ENSG00000267631 [A6NKQ9-2]
GeneIDi114335
KEGGihsa:114335
UCSCiuc002plx.4 human [A6NKQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52436.1
BC126460 mRNA Translation: AAI26461.1
CCDSiCCDS12751.2 [A6NKQ9-2]
RefSeqiNP_203695.2, NM_033377.1 [A6NKQ9-2]
UniGeneiHs.659014

3D structure databases

ProteinModelPortaliA6NKQ9
SMRiA6NKQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125315, 1 interactor

PTM databases

iPTMnetiA6NKQ9
PhosphoSitePlusiA6NKQ9

Proteomic databases

MaxQBiA6NKQ9
PRIDEiA6NKQ9
ProteomicsDBi1426
1427 [A6NKQ9-2]

Protocols and materials databases

DNASUi114335
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301407; ENSP00000301407; ENSG00000267631 [A6NKQ9-2]
GeneIDi114335
KEGGihsa:114335
UCSCiuc002plx.4 human [A6NKQ9-1]

Organism-specific databases

CTDi114335
DisGeNETi114335
EuPathDBiHostDB:ENSG00000267631.4
GeneCardsiCGB1
HGNCiHGNC:16721 CGB1
HPAiHPA038925
HPA038934
MIMi608823 gene
neXtProtiNX_A6NKQ9
OpenTargetsiENSG00000267631
PharmGKBiPA26435
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOVERGENiHBG006698
InParanoidiA6NKQ9
KOiK10045
OrthoDBiEOG091G0XFH
TreeFamiTF332940

Miscellaneous databases

GeneWikiiCGB1
GenomeRNAii114335
PROiPR:A6NKQ9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000267631 Expressed in 35 organ(s), highest expression level in pituitary gland
CleanExiHS_CGB1
ExpressionAtlasiA6NKQ9 baseline and differential
GenevisibleiA6NKQ9 HS

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCGB1_HUMAN
AccessioniPrimary (citable) accession number: A6NKQ9
Secondary accession number(s): A4FVC8, A8MUK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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