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Protein

Transmembrane protein 200C

Gene

TMEM200C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 200C
Alternative name(s):
Transmembrane protein TTMA
Two transmembrane domain-containing family member A
Gene namesi
Name:TMEM200C
Synonyms:TTMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000206432.4
HGNCiHGNC:37208 TMEM200C
neXtProtiNX_A6NKL6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206432
PharmGKBiPA165429148

Polymorphism and mutation databases

BioMutaiTMEM200C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003489441 – 621Transmembrane protein 200CAdd BLAST621

Proteomic databases

EPDiA6NKL6
PaxDbiA6NKL6
PRIDEiA6NKL6
ProteomicsDBi1420

PTM databases

iPTMnetiA6NKL6
PhosphoSitePlusiA6NKL6

Expressioni

Gene expression databases

BgeeiENSG00000206432 Expressed in 119 organ(s), highest expression level in endothelial cell
GenevisibleiA6NKL6 HS

Organism-specific databases

HPAiHPA047253
HPA050490

Structurei

3D structure databases

ProteinModelPortaliA6NKL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi215 – 347Ala-richAdd BLAST133
Compositional biasi476 – 517Pro-richAdd BLAST42

Sequence similaritiesi

Belongs to the TMEM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000208781
InParanoidiA6NKL6
OMAiCSPPESW
OrthoDBiEOG091G05JS
PhylomeDBiA6NKL6
TreeFamiTF332635

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit

Sequencei

Sequence statusi: Complete.

A6NKL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIATGGLLRI SARKQDPLRP PSQIPKRKRK AKKRRKNDVV VVKGKLKLCS
60 70 80 90 100
ISGLIALCGI LVLLVGIAMA VVGYWPKATG TNREGGKQLP PAGSSHRVPT
110 120 130 140 150
TANSSSSGSK NRSRSHPRAP GGVNSSSAGA PRSTPPARAA SPSSSSTSVG
160 170 180 190 200
FFFRIFSGYL HSDKLKVFGP LIMGIGIFLF ICANAVLHEN RDKKTKIINL
210 220 230 240 250
RDLYSTVIDV HSLRAKDLAA AAAAAAAAAA SSSSSAPAAA PPGAIPLNGF
260 270 280 290 300
LSYVQSRGLE LKPGGCGGSG DAFGAAAMLA KGSWPPHPAA PSGGRPRGAA
310 320 330 340 350
SPPDLASSPR CPREPPSLAE AVYSVYRERS GVAGSRRAAA ATAAAAASSC
360 370 380 390 400
SSPAPCSPPE SWGRQSTASS FVDSSLSAFA LLPLQGGRDR GGDAEGASCS
410 420 430 440 450
WQRPPGERGS QEIPRGELDL SMTNLRGAEG SMRGARREPE EPEGAVAARA
460 470 480 490 500
ARGQGGRLPR TGRYAALRRR STSGLPDYRA PPSPEPPPSP GSADPDSSPL
510 520 530 540 550
AKAASPSPPL RLEGSPPTRR DSGSSQSDDP SSSNKGYTPL REAGTSTESV
560 570 580 590 600
LDAVAGQTRD SAVAAPVLGA EQSSPEGASQ EPPTAEQPQP VQRQFTNKEK
610 620
LIMISRSHAI GVEEELESTG I
Length:621
Mass (Da):63,928
Last modified:September 2, 2008 - v2
Checksum:i5192A3FA727CAFB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005433 Genomic DNA No translation available.
BK005124 mRNA Translation: DAA05326.1
CCDSiCCDS45825.1
RefSeqiNP_001073678.1, NM_001080209.2
XP_011524031.1, XM_011525729.2

Genome annotation databases

EnsembliENST00000383490; ENSP00000372982; ENSG00000206432
ENST00000581347; ENSP00000463375; ENSG00000206432
GeneIDi645369
KEGGihsa:645369
UCSCiuc002kmx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005433 Genomic DNA No translation available.
BK005124 mRNA Translation: DAA05326.1
CCDSiCCDS45825.1
RefSeqiNP_001073678.1, NM_001080209.2
XP_011524031.1, XM_011525729.2

3D structure databases

ProteinModelPortaliA6NKL6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NKL6
PhosphoSitePlusiA6NKL6

Polymorphism and mutation databases

BioMutaiTMEM200C

Proteomic databases

EPDiA6NKL6
PaxDbiA6NKL6
PRIDEiA6NKL6
ProteomicsDBi1420

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383490; ENSP00000372982; ENSG00000206432
ENST00000581347; ENSP00000463375; ENSG00000206432
GeneIDi645369
KEGGihsa:645369
UCSCiuc002kmx.1 human

Organism-specific databases

CTDi645369
EuPathDBiHostDB:ENSG00000206432.4
GeneCardsiTMEM200C
HGNCiHGNC:37208 TMEM200C
HPAiHPA047253
HPA050490
neXtProtiNX_A6NKL6
OpenTargetsiENSG00000206432
PharmGKBiPA165429148
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000208781
InParanoidiA6NKL6
OMAiCSPPESW
OrthoDBiEOG091G05JS
PhylomeDBiA6NKL6
TreeFamiTF332635

Miscellaneous databases

GenomeRNAii645369
PROiPR:A6NKL6

Gene expression databases

BgeeiENSG00000206432 Expressed in 119 organ(s), highest expression level in endothelial cell
GenevisibleiA6NKL6 HS

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT200C_HUMAN
AccessioniPrimary (citable) accession number: A6NKL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 10, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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