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Protein

Transmembrane protein 200C

Gene

TMEM200C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 200C
Alternative name(s):
Transmembrane protein TTMA
Two transmembrane domain-containing family member A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM200C
Synonyms:TTMA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000206432.4

Human Gene Nomenclature Database

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HGNCi
HGNC:37208 TMEM200C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NKL6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000206432

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165429148

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM200C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003489441 – 621Transmembrane protein 200CAdd BLAST621

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NKL6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NKL6

PRoteomics IDEntifications database

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PRIDEi
A6NKL6

ProteomicsDB human proteome resource

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ProteomicsDBi
1420

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NKL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NKL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206432 Expressed in 119 organ(s), highest expression level in endothelial cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NKL6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047253
HPA050490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NKL6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 347Ala-richAdd BLAST133
Compositional biasi476 – 517Pro-richAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4823 Eukaryota
ENOG41106JF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000208781

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NKL6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSPPESW

Database of Orthologous Groups

More...
OrthoDBi
565871at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NKL6

TreeFam database of animal gene trees

More...
TreeFami
TF332635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018787 DUF2371_TMEM200

The PANTHER Classification System

More...
PANTHERi
PTHR31815 PTHR31815, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10177 DUF2371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NKL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIATGGLLRI SARKQDPLRP PSQIPKRKRK AKKRRKNDVV VVKGKLKLCS
60 70 80 90 100
ISGLIALCGI LVLLVGIAMA VVGYWPKATG TNREGGKQLP PAGSSHRVPT
110 120 130 140 150
TANSSSSGSK NRSRSHPRAP GGVNSSSAGA PRSTPPARAA SPSSSSTSVG
160 170 180 190 200
FFFRIFSGYL HSDKLKVFGP LIMGIGIFLF ICANAVLHEN RDKKTKIINL
210 220 230 240 250
RDLYSTVIDV HSLRAKDLAA AAAAAAAAAA SSSSSAPAAA PPGAIPLNGF
260 270 280 290 300
LSYVQSRGLE LKPGGCGGSG DAFGAAAMLA KGSWPPHPAA PSGGRPRGAA
310 320 330 340 350
SPPDLASSPR CPREPPSLAE AVYSVYRERS GVAGSRRAAA ATAAAAASSC
360 370 380 390 400
SSPAPCSPPE SWGRQSTASS FVDSSLSAFA LLPLQGGRDR GGDAEGASCS
410 420 430 440 450
WQRPPGERGS QEIPRGELDL SMTNLRGAEG SMRGARREPE EPEGAVAARA
460 470 480 490 500
ARGQGGRLPR TGRYAALRRR STSGLPDYRA PPSPEPPPSP GSADPDSSPL
510 520 530 540 550
AKAASPSPPL RLEGSPPTRR DSGSSQSDDP SSSNKGYTPL REAGTSTESV
560 570 580 590 600
LDAVAGQTRD SAVAAPVLGA EQSSPEGASQ EPPTAEQPQP VQRQFTNKEK
610 620
LIMISRSHAI GVEEELESTG I
Length:621
Mass (Da):63,928
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5192A3FA727CAFB7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AP005433 Genomic DNA No translation available.
BK005124 mRNA Translation: DAA05326.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45825.1

NCBI Reference Sequences

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RefSeqi
NP_001073678.1, NM_001080209.2
XP_011524031.1, XM_011525729.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383490; ENSP00000372982; ENSG00000206432
ENST00000581347; ENSP00000463375; ENSG00000206432

Database of genes from NCBI RefSeq genomes

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GeneIDi
645369

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:645369

UCSC genome browser

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UCSCi
uc002kmx.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005433 Genomic DNA No translation available.
BK005124 mRNA Translation: DAA05326.1
CCDSiCCDS45825.1
RefSeqiNP_001073678.1, NM_001080209.2
XP_011524031.1, XM_011525729.2

3D structure databases

ProteinModelPortaliA6NKL6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NKL6
PhosphoSitePlusiA6NKL6

Polymorphism and mutation databases

BioMutaiTMEM200C

Proteomic databases

EPDiA6NKL6
PaxDbiA6NKL6
PRIDEiA6NKL6
ProteomicsDBi1420

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383490; ENSP00000372982; ENSG00000206432
ENST00000581347; ENSP00000463375; ENSG00000206432
GeneIDi645369
KEGGihsa:645369
UCSCiuc002kmx.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
645369
EuPathDBiHostDB:ENSG00000206432.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM200C
HGNCiHGNC:37208 TMEM200C
HPAiHPA047253
HPA050490
neXtProtiNX_A6NKL6
OpenTargetsiENSG00000206432
PharmGKBiPA165429148

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000208781
InParanoidiA6NKL6
OMAiCSPPESW
OrthoDBi565871at2759
PhylomeDBiA6NKL6
TreeFamiTF332635

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
645369

Protein Ontology

More...
PROi
PR:A6NKL6

Gene expression databases

BgeeiENSG00000206432 Expressed in 119 organ(s), highest expression level in endothelial cell
GenevisibleiA6NKL6 HS

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT200C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NKL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 16, 2019
This is version 75 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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