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Entry version 91 (13 Feb 2019)
Sequence version 1 (24 Jul 2007)
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Protein

AT-rich interactive domain-containing protein 3C

Gene

ARID3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3C
Short name:
ARID domain-containing protein 3C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID3C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000205143.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21209 ARID3C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NKF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000205143

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134928507

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARID3C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003330011 – 412AT-rich interactive domain-containing protein 3CAdd BLAST412

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NKF2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NKF2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NKF2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NKF2

PRoteomics IDEntifications database

More...
PRIDEi
A6NKF2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1410

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NKF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NKF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205143 Expressed in 32 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126518, 1 interactor

Protein interaction database and analysis system

More...
IntActi
A6NKF2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368189

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NKF2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NKF2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 205ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini304 – 389REKLESPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 75Glu-richAdd BLAST25
Compositional biasi240 – 412Pro-richAdd BLAST173

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2744 Eukaryota
ENOG410Y2AP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236281

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050574

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NKF2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDHRTLQ

Database of Orthologous Groups

More...
OrthoDBi
1347369at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NKF2

TreeFam database of animal gene trees

More...
TreeFami
TF320364

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR023334 REKLES_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388 ARID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit
PS51486 REKLES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NKF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEALQKQQAA RLAQGVGPLA PACPLLPPQP PLPDHRTLQA PEGALGNVGA
60 70 80 90 100
EEEEDAEEDE EKREEAGAEE EAAEESRPGA QGPSSPSSQP PGLHPHEWTY
110 120 130 140 150
EEQFKQLYEL DADPKRKEFL DDLFSFMQKR GTPVNRVPIM AKQVLDLYAL
160 170 180 190 200
FRLVTAKGGL VEVINRKVWR EVTRGLSLPT TITSAAFTLR TQYMKYLYPY
210 220 230 240 250
ECETRALSSP GELQAAIDSN RREGRRQAYT ATPLFGLAGP PPRGAQDPAL
260 270 280 290 300
GPGPAPPATQ SSPGPAQGST SGLPAHACAQ LSPSPIKKEE SGIPNPCLAL
310 320 330 340 350
PVGLALGPTR EKLAPEEPPE KRAVLMGPMD PPRPCMPPSF LPRGKVPLRE
360 370 380 390 400
ERLDGPLNLA GSGISSINMA LEINGVVYTG VLFARRQPVP ASQGPTNPAP
410
PPSTGPPSSI LP
Length:412
Mass (Da):44,073
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4F27053248A49A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043033310R → Q. Corresponds to variant dbSNP:rs12337871Ensembl.1
Natural variantiVAR_043034335C → G. Corresponds to variant dbSNP:rs3808869Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL450283 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35006.1

NCBI Reference Sequences

More...
RefSeqi
NP_001017363.1, NM_001017363.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.534549

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378909; ENSP00000368189; ENSG00000205143

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
138715

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:138715

UCSC genome browser

More...
UCSCi
uc011lon.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450283 Genomic DNA No translation available.
CCDSiCCDS35006.1
RefSeqiNP_001017363.1, NM_001017363.1
UniGeneiHs.534549

3D structure databases

ProteinModelPortaliA6NKF2
SMRiA6NKF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126518, 1 interactor
IntActiA6NKF2, 4 interactors
STRINGi9606.ENSP00000368189

PTM databases

iPTMnetiA6NKF2
PhosphoSitePlusiA6NKF2

Polymorphism and mutation databases

BioMutaiARID3C

Proteomic databases

EPDiA6NKF2
jPOSTiA6NKF2
MaxQBiA6NKF2
PaxDbiA6NKF2
PRIDEiA6NKF2
ProteomicsDBi1410

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
138715
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378909; ENSP00000368189; ENSG00000205143
GeneIDi138715
KEGGihsa:138715
UCSCiuc011lon.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
138715
EuPathDBiHostDB:ENSG00000205143.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARID3C
HGNCiHGNC:21209 ARID3C
neXtProtiNX_A6NKF2
OpenTargetsiENSG00000205143
PharmGKBiPA134928507

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00940000160028
HOGENOMiHOG000236281
HOVERGENiHBG050574
InParanoidiA6NKF2
OMAiPDHRTLQ
OrthoDBi1347369at2759
PhylomeDBiA6NKF2
TreeFamiTF320364

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
138715

Protein Ontology

More...
PROi
PR:A6NKF2

Gene expression databases

BgeeiENSG00000205143 Expressed in 32 organ(s), highest expression level in liver

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR023334 REKLES_domain
PfamiView protein in Pfam
PF01388 ARID, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51486 REKLES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI3C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NKF2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: February 13, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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