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Protein

SAC3 domain-containing protein 1

Gene

SAC3D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in centrosome duplication and mitotic progression.By similarity

Caution

It is uncertain whether Met-1 or Met-47 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
SAC3 domain-containing protein 1
Alternative name(s):
SAC3 homology domain-containing protein 1
Gene namesi
Name:SAC3D1
Synonyms:SHD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000168061.13
HGNCiHGNC:30179 SAC3D1
neXtProtiNX_A6NKF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29901

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003082041 – 404SAC3 domain-containing protein 1Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei402PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NKF1
MaxQBiA6NKF1
PaxDbiA6NKF1
PRIDEiA6NKF1
ProteomicsDBi1408
1409 [A6NKF1-2]
TopDownProteomicsiA6NKF1-2 [A6NKF1-2]

PTM databases

iPTMnetiA6NKF1
PhosphoSitePlusiA6NKF1

Expressioni

Gene expression databases

BgeeiENSG00000168061 Expressed in 199 organ(s), highest expression level in amniotic fluid
CleanExiHS_SAC3D1
GenevisibleiA6NKF1 HS

Organism-specific databases

HPAiHPA042677

Interactioni

Subunit structurei

May be part of a SEM1-containing complex.1 Publication

Protein-protein interaction databases

IntActiA6NKF1, 2 interactors
STRINGi9606.ENSP00000381824

Structurei

3D structure databases

ProteinModelPortaliA6NKF1
SMRiA6NKF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 379PCIPROSITE-ProRule annotationAdd BLAST177

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 118Pro-richAdd BLAST111

Sequence similaritiesi

Belongs to the SAC3 family.Curated

Phylogenomic databases

eggNOGiKOG1860 Eukaryota
COG5079 LUCA
HOGENOMiHOG000168632
HOVERGENiHBG108455
InParanoidiA6NKF1
OrthoDBiEOG091G0CJ7
PhylomeDBiA6NKF1

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NKF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGRRAQTGS APPRPAAPHP RPASRAFPQH CRPRDAERPP SPRSPLMPGC
60 70 80 90 100
ELPVGTCPDM CPAAERAQRE REHRLHRLEV VPGCRQDPPR ADPQRAVKEY
110 120 130 140 150
SRPAAGKPRP PPSQLRPPSV LLATVRYLAG EVAESADIAR AEVASFVADR
160 170 180 190 200
LRAVLLDLAL QGAGDAEAAV VLEAALATLL TVVARLGPDA ARGPADPVLL
210 220 230 240 250
QAQVQEGFGS LRRCYARGAG PHPRQPAFQG LFLLYNLGSV EALHEVLQLP
260 270 280 290 300
AALRACPPLR KALAVDAAFR EGNAARLFRL LQTLPYLPSC AVQCHVGHAR
310 320 330 340 350
REALARFARA FSTPKGQTLP LGFMVNLLAL DGLREARDLC QAHGLPLDGE
360 370 380 390 400
ERVVFLRGRY VEEGLPPAST CKVLVESKLR GRTLEEVVMA EEEDEGTDRP

GSPA
Length:404
Mass (Da):43,553
Last modified:March 24, 2009 - v2
Checksum:i9B3499AAA23F97B7
GO
Isoform 2 (identifier: A6NKF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-404: SVEALHEVLQ...EGTDRPGSPA → ESGSWRLGRA...PARPSARPWR

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):30,913
Checksum:i6E23EC439A9A6628
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WC89F8WC89_HUMAN
SAC3 domain-containing protein 1
SAC3D1
358Annotation score:
H0YEW7H0YEW7_HUMAN
SAC3 domain-containing protein 1
SAC3D1
239Annotation score:

Sequence cautioni

The sequence AP003068 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181T → A in AAB50210 (PubMed:9110174).Curated1
Sequence conflicti181T → A in BC007448 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0367558T → P2 PublicationsCorresponds to variant dbSNP:rs10160811Ensembl.1
Natural variantiVAR_062213155L → R2 PublicationsCorresponds to variant dbSNP:rs12271134Ensembl.1
Natural variantiVAR_036756186L → P. Corresponds to variant dbSNP:rs3741390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036589239 – 404SVEAL…PGSPA → ESGSWRLGRAWGQEPTMTVE ARWKPCMRFYSCLLPCAPAR PSARPWR in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79266 mRNA Translation: AAB50210.1
AP003068 Genomic DNA No translation available.
BC007448 mRNA No translation available.
UniGeneiHs.23642

Genome annotation databases

EnsembliENST00000614106; ENSP00000482039; ENSG00000168061
UCSCiuc058dcn.1 human [A6NKF1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79266 mRNA Translation: AAB50210.1
AP003068 Genomic DNA No translation available.
BC007448 mRNA No translation available.
UniGeneiHs.23642

3D structure databases

ProteinModelPortaliA6NKF1
SMRiA6NKF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NKF1, 2 interactors
STRINGi9606.ENSP00000381824

PTM databases

iPTMnetiA6NKF1
PhosphoSitePlusiA6NKF1

Proteomic databases

EPDiA6NKF1
MaxQBiA6NKF1
PaxDbiA6NKF1
PRIDEiA6NKF1
ProteomicsDBi1408
1409 [A6NKF1-2]
TopDownProteomicsiA6NKF1-2 [A6NKF1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614106; ENSP00000482039; ENSG00000168061
UCSCiuc058dcn.1 human [A6NKF1-1]

Organism-specific databases

DisGeNETi29901
EuPathDBiHostDB:ENSG00000168061.13
GeneCardsiSAC3D1
HGNCiHGNC:30179 SAC3D1
HPAiHPA042677
neXtProtiNX_A6NKF1
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1860 Eukaryota
COG5079 LUCA
HOGENOMiHOG000168632
HOVERGENiHBG108455
InParanoidiA6NKF1
OrthoDBiEOG091G0CJ7
PhylomeDBiA6NKF1

Miscellaneous databases

PROiPR:A6NKF1

Gene expression databases

BgeeiENSG00000168061 Expressed in 199 organ(s), highest expression level in amniotic fluid
CleanExiHS_SAC3D1
GenevisibleiA6NKF1 HS

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAC31_HUMAN
AccessioniPrimary (citable) accession number: A6NKF1
Secondary accession number(s): A8MX08, Q99773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 24, 2009
Last modified: September 12, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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