UniProtKB - A6NKB5 (PCX2_HUMAN)
Protein
Pecanex-like protein 2
Gene
PCNX2
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).2 Publications
Miscellaneous
PCNXL2 is characterized by high mutational frequencies and biallelic mutations in MSI-H colorectal tumors, and is thus likely to be a target gene in these tumors.
Enzyme and pathway databases
PathwayCommonsi | A6NKB5 |
Names & Taxonomyi
Protein namesi | Recommended name: Pecanex-like protein 2Alternative name(s): Pecanex homolog protein 2Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8736, PCNX2 |
MIMi | 617656, gene |
neXtProti | NX_A6NKB5 |
VEuPathDBi | HostDB:ENSG00000135749.18 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 57 – 77 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 844 – 864 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 868 – 888 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 901 – 921 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 952 – 972 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 983 – 1003 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1029 – 1049 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1099 – 1119 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1124 – 1144 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1193 – 1213 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1237 – 1257 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1265 – 1285 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1302 – 1322 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1324 – 1344 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 80003 |
OpenTargetsi | ENSG00000135749 |
PharmGKBi | PA33081 |
Miscellaneous databases
Pharosi | A6NKB5, Tbio |
Genetic variation databases
BioMutai | PCNX2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333965 | 1 – 2137 | Pecanex-like protein 2Add BLAST | 2137 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 550 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 572 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 587 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 598 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 613 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1412 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1553 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1818 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2054 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | A6NKB5 |
PaxDbi | A6NKB5 |
PeptideAtlasi | A6NKB5 |
PRIDEi | A6NKB5 |
ProteomicsDBi | 1391 [A6NKB5-1] 1392 [A6NKB5-2] 1393 [A6NKB5-3] 1394 [A6NKB5-4] 1395 [A6NKB5-5] |
PTM databases
GlyGeni | A6NKB5, 11 sites |
iPTMneti | A6NKB5 |
PhosphoSitePlusi | A6NKB5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135749, Expressed in middle temporal gyrus and 225 other tissues |
ExpressionAtlasi | A6NKB5, baseline and differential |
Genevisiblei | A6NKB5, HS |
Organism-specific databases
HPAi | ENSG00000135749, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Hide detailsIsoform 5 [A6NKB5-5]
With | #Exp. | IntAct |
---|---|---|
ABHD5 [Q8WTS1] | 3 | EBI-17616589,EBI-2813554 |
ORMDL1 [Q9P0S3] | 3 | EBI-17616589,EBI-1054848 |
SLC30A2 [Q9BRI3] | 3 | EBI-17616589,EBI-8644112 |
Protein-protein interaction databases
BioGRIDi | 123060, 8 interactors |
IntActi | A6NKB5, 4 interactors |
STRINGi | 9606.ENSP00000258229 |
Miscellaneous databases
RNActi | A6NKB5, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1937 – 2063 | Ser-richAdd BLAST | 127 |
Sequence similaritiesi
Belongs to the pecanex family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3604, Eukaryota |
GeneTreei | ENSGT00940000157374 |
HOGENOMi | CLU_000602_3_0_1 |
InParanoidi | A6NKB5 |
OMAi | MCRRASQ |
PhylomeDBi | A6NKB5 |
TreeFami | TF313570 |
Family and domain databases
InterProi | View protein in InterPro IPR039797, Pecanex IPR007735, Pecanex_C |
PANTHERi | PTHR12372, PTHR12372, 1 hit |
Pfami | View protein in Pfam PF05041, Pecanex_C, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A6NKB5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSQVLQLLR QGVWAALTGG WYHDPEQSKF TNSCHLYLWL FLLLLPLALH
60 70 80 90 100
LAFPPNAIIV FFYCSAVTIF FTIIKLVSYR LHLMFDKGEV IQQKPSRKEE
110 120 130 140 150
KPNKDKEAKG EHITNHRNPS NNRQIHNGKK EEASRNLSTP PLRCSSRGQS
160 170 180 190 200
ITSHHSSGPL ELSAQETVED LKGVILLEDH PIAPVSSTSP GIKVESLPAS
210 220 230 240 250
QAHMLETTTK SVIPVKPVAT ETLINGKGKE RGGKGQPPLR HRSEGGLVDK
260 270 280 290 300
GPLKKLPHLS LSQYDLLETD VSFQPWGSEN SVLIPEPVSC PRGSIRERVQ
310 320 330 340 350
SKSPQDSLSS SCPQCDTIVA KPVEEPADTS CQVDTSCQGD LPLHQEVDSS
360 370 380 390 400
DSEVAVTLID TSQPGDPLSL HEPIKIVITM SSTPNSMTDL ESSLHLRVVG
410 420 430 440 450
TEKTSVKSDA EPTNPGAAGS PNAEQISIPV ITLDLPEGGG GGVPCPEGNG
460 470 480 490 500
SERTPERLKT RVSTNQCSGY GSGEGGNAIK DHSSSSREPW ESVSRLTPDT
510 520 530 540 550
GSESKVGKEG QTNLDPSSCK SSHEKRHARV LSVDSGTDVF LSKSSAEIVN
560 570 580 590 600
DTEKTMPTSK SDLEAKEGQM PNESNFLEFV SLLESINTSK MTASSQLNGS
610 620 630 640 650
AEQNEESGLL RDNCSQEKKE EILENEKPSG HSSKQGKPDL QSQDHTSTGP
660 670 680 690 700
ACTQPAKTTA FFQGNRQRQI IYRVTSQQDS SVLQVISGPE TSVQEEISVD
710 720 730 740 750
AMHVFIDEHG EIRSCYLKSG NQKEGPLQPL PSNNDCLSQA REMQVSSSST
760 770 780 790 800
TTSESQDPSS GDPAVSALQQ QLLLMVARRT QSETPRHVSQ DLEASSCSST
810 820 830 840 850
QGKFNREQFY KFIIFPGKWI KVWYDRLTLL ALLDRTEDIK ENVLAILLIV
860 870 880 890 900
LVSLLGFLTL SQGFCKDMWV LLFCLVMASC QYSLLKSVQP DPASPIHGHN
910 920 930 940 950
QIITYSRPIY FCVLCGLILL LDTGAKARHP PSYVVYGLKL FSPVFLQSAR
960 970 980 990 1000
DYLIVFLYCF PAISLLGLFP QINTFCTYLL EQIDMLFFGG SAVSGITSAV
1010 1020 1030 1040 1050
YSVARSVLAA ALLHAVCFSA VKEPWSMQHI PALFSAFCGL LVALSYHLSR
1060 1070 1080 1090 1100
QSSDPSVLMS FIQCRLFPKF LHQNLAESAA DPLPKKMKDS VTDVLKWDLI
1110 1120 1130 1140 1150
VCAVVAVLSF AVSASTVFLS LRPFLSIVLF ALAGAVGFVT HYVLPQLRKH
1160 1170 1180 1190 1200
HPWMWISHPI LKNKEYHQRE VRDVAHLMWF ERLYVWLQCF EKYILYPALI
1210 1220 1230 1240 1250
LNALTIDAFL ISNHRRLGTH WDIFLMIIAG MKLLRTSFCN PVYQFINLSF
1260 1270 1280 1290 1300
TVIFFHFDYK DISESFLLDF FMVSILFSKL GDLLHKLQFV LTYVAPWQMA
1310 1320 1330 1340 1350
WGSSFHVFAQ LFAIPHSAML FFQTIATSIF STPLSPFLGS VIFITSYVRP
1360 1370 1380 1390 1400
VKFWEKNYNT RRVDNSNTRL AVQIERDPGN DDNNLNSIFY EHLTRTLQES
1410 1420 1430 1440 1450
LCGDLVLGRW GNYSSGDCFI LASDDLNAFV HLIEIGNGLV TFQLRGLEFR
1460 1470 1480 1490 1500
GTYCQQREVE AIMEGDEEDR GCCCCKPGHL PHLLSCNAAF HLRWLTWEIT
1510 1520 1530 1540 1550
QTQYILEGYS ILDNNAATML QVFDLRRILI RYYIKSIIYY MVTSPKLLSW
1560 1570 1580 1590 1600
IKNESLLKSL QPFAKWHYIE RDLAMFNINI DDDYVPCLQG ITRASFCNVY
1610 1620 1630 1640 1650
LEWIQHCARK RQEPSTTLDS DEDSPLVTLS FALCTLGRRA LGTAAHNMAI
1660 1670 1680 1690 1700
SLDSFLYGLH VLFKGDFRIT ARDEWVFADM DLLHKVVAPA IRMSLKLHQD
1710 1720 1730 1740 1750
QFTCPDEYED PAVLYEAIQS FEKKVVICHE GDPAWRGAVL SNKEELLTLR
1760 1770 1780 1790 1800
HVVDEGADEY KVIMLHRSFL SFKVIKVNKE CVRGLWAGQQ QELIFLRNRN
1810 1820 1830 1840 1850
PERGSIQNNK QVLRNLINSS CDQPLGYPMY VSPLTTSYLG THRQLKNIWG
1860 1870 1880 1890 1900
GPITLDRIRT WFWTKWVRMR KDCNARQHSG GNIEDVDGGG APTTGGNNAP
1910 1920 1930 1940 1950
SGGSQESSAE QPRKGGAQHG VSSCEGTQRT GRRKGRSQSV QAHSALSQRP
1960 1970 1980 1990 2000
PMLSSSGPIL ESRQTFLQTS TSVHELAQRL SGSRLSLHAS ATSLHSQPPP
2010 2020 2030 2040 2050
VTTTGHLSVR ERAEALIRSS LGSSTSSTLS FLFGKRSFSS ALVISGLSAA
2060 2070 2080 2090 2100
EGGNTSDTQS SSSVNIVMGP SARAASQATR HLSEPCEPPD ATEQGQLHDR
2110 2120 2130
CLAEAVADTL GVVCRRASQE DMGLDDTASQ QSVSDEQ
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSK9 | A0A0A0MSK9_HUMAN | Pecanex-like protein | PCNX2 | 412 | Annotation score: | ||
E7EVZ6 | E7EVZ6_HUMAN | Pecanex-like protein | PCNX2 | 424 | Annotation score: | ||
H0YAV6 | H0YAV6_HUMAN | Pecanex-like protein | PCNX2 | 178 | Annotation score: | ||
H0YB15 | H0YB15_HUMAN | Pecanex-like protein | PCNX2 | 490 | Annotation score: | ||
H0YBD1 | H0YBD1_HUMAN | Pecanex-like protein | PCNX2 | 181 | Annotation score: | ||
H0YAR6 | H0YAR6_HUMAN | Pecanex-like protein | PCNX2 | 109 | Annotation score: | ||
H0YB30 | H0YB30_HUMAN | Pecanex-like protein | PCNX2 | 47 | Annotation score: | ||
H0YBF4 | H0YBF4_HUMAN | Pecanex-like protein | PCNX2 | 218 | Annotation score: | ||
H0YBD6 | H0YBD6_HUMAN | Pecanex-like protein | PCNX2 | 45 | Annotation score: |
Sequence cautioni
The sequence BAA23708 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84904 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050479 | 117 | R → K. Corresponds to variant dbSNP:rs1033325Ensembl. | 1 | |
Natural variantiVAR_043341 | 454 | T → A. Corresponds to variant dbSNP:rs10910120Ensembl. | 1 | |
Natural variantiVAR_061498 | 1901 | S → N1 PublicationCorresponds to variant dbSNP:rs56231757Ensembl. | 1 | |
Natural variantiVAR_061499 | 1984 | R → Q. Corresponds to variant dbSNP:rs41309639Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033605 | 1 – 1462 | Missing in isoform 4. 1 PublicationAdd BLAST | 1462 | |
Alternative sequenceiVSP_033606 | 1 – 1348 | Missing in isoform 3. 1 PublicationAdd BLAST | 1348 | |
Alternative sequenceiVSP_035048 | 1 – 867 | Missing in isoform 5. 1 PublicationAdd BLAST | 867 | |
Alternative sequenceiVSP_033607 | 1 – 701 | Missing in isoform 2. 1 PublicationAdd BLAST | 701 | |
Alternative sequenceiVSP_033608 | 955 – 987 | VFLYC…IDMLF → GKIMNSHKDFFTSEKKKDKI ISAISSVIFLKSW in isoform 2. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_033609 | 988 – 2137 | Missing in isoform 2. 1 PublicationAdd BLAST | 1150 | |
Alternative sequenceiVSP_035049 | 1280 – 1288 | LGDLLHKLQ → VFLGYVRQK in isoform 5. 1 Publication | 9 | |
Alternative sequenceiVSP_035050 | 1289 – 2137 | Missing in isoform 5. 1 PublicationAdd BLAST | 849 | |
Alternative sequenceiVSP_033610 | 1349 – 1359 | RPVKFWEKNYN → MTFYPFVASSS in isoform 3. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_033611 | 2081 – 2137 | HLSEP…VSDEQ → VRGWAGLTRTGWDGGTGSWP ERGTCLAFPPFCLQNPIPFS MGLPE in isoform 3. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007895 mRNA Translation: BAA23708.2 Different initiation. AK074078 mRNA Translation: BAB84904.1 Different initiation. AK021445 mRNA Translation: BAB13826.1 AL139342, AL122003, AL133289 Genomic DNA Translation: CAI18866.1 AL133291 Genomic DNA No translation available. AL133380 Genomic DNA No translation available. AL139342 Genomic DNA Translation: CAI18867.1 AL122003, AL139342, AL133289 Genomic DNA Translation: CAI22240.1 AL122003, AL133289 Genomic DNA Translation: CAI22241.1 AL133289, AL139342, AL122003 Genomic DNA Translation: CAI22872.1 AL133289, AL122003 Genomic DNA Translation: CAI22873.1 AL359819 Genomic DNA No translation available. BC008300 mRNA Translation: AAH08300.2 |
CCDSi | CCDS44335.1 [A6NKB5-1] |
RefSeqi | NP_055616.3, NM_014801.3 [A6NKB5-1] |
Genome annotation databases
Ensembli | ENST00000258229; ENSP00000258229; ENSG00000135749 [A6NKB5-1] ENST00000344698; ENSP00000340759; ENSG00000135749 [A6NKB5-3] |
GeneIDi | 80003 |
KEGGi | hsa:80003 |
UCSCi | uc001hvk.1, human [A6NKB5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007895 mRNA Translation: BAA23708.2 Different initiation. AK074078 mRNA Translation: BAB84904.1 Different initiation. AK021445 mRNA Translation: BAB13826.1 AL139342, AL122003, AL133289 Genomic DNA Translation: CAI18866.1 AL133291 Genomic DNA No translation available. AL133380 Genomic DNA No translation available. AL139342 Genomic DNA Translation: CAI18867.1 AL122003, AL139342, AL133289 Genomic DNA Translation: CAI22240.1 AL122003, AL133289 Genomic DNA Translation: CAI22241.1 AL133289, AL139342, AL122003 Genomic DNA Translation: CAI22872.1 AL133289, AL122003 Genomic DNA Translation: CAI22873.1 AL359819 Genomic DNA No translation available. BC008300 mRNA Translation: AAH08300.2 |
CCDSi | CCDS44335.1 [A6NKB5-1] |
RefSeqi | NP_055616.3, NM_014801.3 [A6NKB5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123060, 8 interactors |
IntActi | A6NKB5, 4 interactors |
STRINGi | 9606.ENSP00000258229 |
PTM databases
GlyGeni | A6NKB5, 11 sites |
iPTMneti | A6NKB5 |
PhosphoSitePlusi | A6NKB5 |
Genetic variation databases
BioMutai | PCNX2 |
Proteomic databases
jPOSTi | A6NKB5 |
PaxDbi | A6NKB5 |
PeptideAtlasi | A6NKB5 |
PRIDEi | A6NKB5 |
ProteomicsDBi | 1391 [A6NKB5-1] 1392 [A6NKB5-2] 1393 [A6NKB5-3] 1394 [A6NKB5-4] 1395 [A6NKB5-5] |
Protocols and materials databases
Antibodypediai | 11747, 49 antibodies |
Genome annotation databases
Ensembli | ENST00000258229; ENSP00000258229; ENSG00000135749 [A6NKB5-1] ENST00000344698; ENSP00000340759; ENSG00000135749 [A6NKB5-3] |
GeneIDi | 80003 |
KEGGi | hsa:80003 |
UCSCi | uc001hvk.1, human [A6NKB5-1] |
Organism-specific databases
CTDi | 80003 |
DisGeNETi | 80003 |
GeneCardsi | PCNX2 |
HGNCi | HGNC:8736, PCNX2 |
HPAi | ENSG00000135749, Tissue enhanced (brain) |
MIMi | 617656, gene |
neXtProti | NX_A6NKB5 |
OpenTargetsi | ENSG00000135749 |
PharmGKBi | PA33081 |
VEuPathDBi | HostDB:ENSG00000135749.18 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3604, Eukaryota |
GeneTreei | ENSGT00940000157374 |
HOGENOMi | CLU_000602_3_0_1 |
InParanoidi | A6NKB5 |
OMAi | MCRRASQ |
PhylomeDBi | A6NKB5 |
TreeFami | TF313570 |
Enzyme and pathway databases
PathwayCommonsi | A6NKB5 |
Miscellaneous databases
BioGRID-ORCSi | 80003, 5 hits in 864 CRISPR screens |
ChiTaRSi | PCNX2, human |
GenomeRNAii | 80003 |
Pharosi | A6NKB5, Tbio |
PROi | PR:A6NKB5 |
RNActi | A6NKB5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135749, Expressed in middle temporal gyrus and 225 other tissues |
ExpressionAtlasi | A6NKB5, baseline and differential |
Genevisiblei | A6NKB5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039797, Pecanex IPR007735, Pecanex_C |
PANTHERi | PTHR12372, PTHR12372, 1 hit |
Pfami | View protein in Pfam PF05041, Pecanex_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCX2_HUMAN | |
Accessioni | A6NKB5Primary (citable) accession number: A6NKB5 Secondary accession number(s): O43162 Q9HAL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 10, 2021 | |
This is version 107 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families