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UniProtKB - A6NKB5 (PCX2_HUMAN)

Entry version 107 (10 Feb 2021)
Sequence version 3 (20 May 2008)
Previous versions | rss
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Protein

Pecanex-like protein 2

Gene

PCNX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).2 Publications

Miscellaneous

PCNXL2 is characterized by high mutational frequencies and biallelic mutations in MSI-H colorectal tumors, and is thus likely to be a target gene in these tumors.

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A6NKB5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pecanex-like protein 2
Alternative name(s):
Pecanex homolog protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCNX2Imported
Synonyms:KIAA0435, PCNXL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8736, PCNX2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617656, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NKB5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135749.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21
Transmembranei868 – 888HelicalSequence analysisAdd BLAST21
Transmembranei901 – 921HelicalSequence analysisAdd BLAST21
Transmembranei952 – 972HelicalSequence analysisAdd BLAST21
Transmembranei983 – 1003HelicalSequence analysisAdd BLAST21
Transmembranei1029 – 1049HelicalSequence analysisAdd BLAST21
Transmembranei1099 – 1119HelicalSequence analysisAdd BLAST21
Transmembranei1124 – 1144HelicalSequence analysisAdd BLAST21
Transmembranei1193 – 1213HelicalSequence analysisAdd BLAST21
Transmembranei1237 – 1257HelicalSequence analysisAdd BLAST21
Transmembranei1265 – 1285HelicalSequence analysisAdd BLAST21
Transmembranei1302 – 1322HelicalSequence analysisAdd BLAST21
Transmembranei1324 – 1344HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80003

Open Targets

More...OpenTargetsi		ENSG00000135749

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33081

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NKB5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PCNX2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003339651 – 2137Pecanex-like protein 2Add BLAST2137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1818N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2054N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A6NKB5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NKB5

PeptideAtlas

More...PeptideAtlasi		A6NKB5

PRoteomics IDEntifications database

More...PRIDEi		A6NKB5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1391 [A6NKB5-1]
1392 [A6NKB5-2]
1393 [A6NKB5-3]
1394 [A6NKB5-4]
1395 [A6NKB5-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A6NKB5, 11 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NKB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NKB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135749, Expressed in middle temporal gyrus and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A6NKB5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A6NKB5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135749, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123060, 8 interactors

Protein interaction database and analysis system

More...IntActi		A6NKB5, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258229

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NKB5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1937 – 2063Ser-richAdd BLAST127

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3604, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000602_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NKB5

Identification of Orthologs from Complete Genome Data

More...OMAi		MCRRASQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NKB5

TreeFam database of animal gene trees

More...TreeFami		TF313570

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039797, Pecanex
IPR007735, Pecanex_C

The PANTHER Classification System

More...PANTHERi		PTHR12372, PTHR12372, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05041, Pecanex_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NKB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSQVLQLLR QGVWAALTGG WYHDPEQSKF TNSCHLYLWL FLLLLPLALH 
        60         70         80         90        100
LAFPPNAIIV FFYCSAVTIF FTIIKLVSYR LHLMFDKGEV IQQKPSRKEE 
       110        120        130        140        150
KPNKDKEAKG EHITNHRNPS NNRQIHNGKK EEASRNLSTP PLRCSSRGQS 
       160        170        180        190        200
ITSHHSSGPL ELSAQETVED LKGVILLEDH PIAPVSSTSP GIKVESLPAS 
       210        220        230        240        250
QAHMLETTTK SVIPVKPVAT ETLINGKGKE RGGKGQPPLR HRSEGGLVDK 
       260        270        280        290        300
GPLKKLPHLS LSQYDLLETD VSFQPWGSEN SVLIPEPVSC PRGSIRERVQ 
       310        320        330        340        350
SKSPQDSLSS SCPQCDTIVA KPVEEPADTS CQVDTSCQGD LPLHQEVDSS 
       360        370        380        390        400
DSEVAVTLID TSQPGDPLSL HEPIKIVITM SSTPNSMTDL ESSLHLRVVG 
       410        420        430        440        450
TEKTSVKSDA EPTNPGAAGS PNAEQISIPV ITLDLPEGGG GGVPCPEGNG 
       460        470        480        490        500
SERTPERLKT RVSTNQCSGY GSGEGGNAIK DHSSSSREPW ESVSRLTPDT 
       510        520        530        540        550
GSESKVGKEG QTNLDPSSCK SSHEKRHARV LSVDSGTDVF LSKSSAEIVN 
       560        570        580        590        600
DTEKTMPTSK SDLEAKEGQM PNESNFLEFV SLLESINTSK MTASSQLNGS 
       610        620        630        640        650
AEQNEESGLL RDNCSQEKKE EILENEKPSG HSSKQGKPDL QSQDHTSTGP 
       660        670        680        690        700
ACTQPAKTTA FFQGNRQRQI IYRVTSQQDS SVLQVISGPE TSVQEEISVD 
       710        720        730        740        750
AMHVFIDEHG EIRSCYLKSG NQKEGPLQPL PSNNDCLSQA REMQVSSSST 
       760        770        780        790        800
TTSESQDPSS GDPAVSALQQ QLLLMVARRT QSETPRHVSQ DLEASSCSST 
       810        820        830        840        850
QGKFNREQFY KFIIFPGKWI KVWYDRLTLL ALLDRTEDIK ENVLAILLIV 
       860        870        880        890        900
LVSLLGFLTL SQGFCKDMWV LLFCLVMASC QYSLLKSVQP DPASPIHGHN 
       910        920        930        940        950
QIITYSRPIY FCVLCGLILL LDTGAKARHP PSYVVYGLKL FSPVFLQSAR 
       960        970        980        990       1000
DYLIVFLYCF PAISLLGLFP QINTFCTYLL EQIDMLFFGG SAVSGITSAV 
      1010       1020       1030       1040       1050
YSVARSVLAA ALLHAVCFSA VKEPWSMQHI PALFSAFCGL LVALSYHLSR 
      1060       1070       1080       1090       1100
QSSDPSVLMS FIQCRLFPKF LHQNLAESAA DPLPKKMKDS VTDVLKWDLI 
      1110       1120       1130       1140       1150
VCAVVAVLSF AVSASTVFLS LRPFLSIVLF ALAGAVGFVT HYVLPQLRKH 
      1160       1170       1180       1190       1200
HPWMWISHPI LKNKEYHQRE VRDVAHLMWF ERLYVWLQCF EKYILYPALI 
      1210       1220       1230       1240       1250
LNALTIDAFL ISNHRRLGTH WDIFLMIIAG MKLLRTSFCN PVYQFINLSF 
      1260       1270       1280       1290       1300
TVIFFHFDYK DISESFLLDF FMVSILFSKL GDLLHKLQFV LTYVAPWQMA 
      1310       1320       1330       1340       1350
WGSSFHVFAQ LFAIPHSAML FFQTIATSIF STPLSPFLGS VIFITSYVRP 
      1360       1370       1380       1390       1400
VKFWEKNYNT RRVDNSNTRL AVQIERDPGN DDNNLNSIFY EHLTRTLQES 
      1410       1420       1430       1440       1450
LCGDLVLGRW GNYSSGDCFI LASDDLNAFV HLIEIGNGLV TFQLRGLEFR 
      1460       1470       1480       1490       1500
GTYCQQREVE AIMEGDEEDR GCCCCKPGHL PHLLSCNAAF HLRWLTWEIT 
      1510       1520       1530       1540       1550
QTQYILEGYS ILDNNAATML QVFDLRRILI RYYIKSIIYY MVTSPKLLSW 
      1560       1570       1580       1590       1600
IKNESLLKSL QPFAKWHYIE RDLAMFNINI DDDYVPCLQG ITRASFCNVY 
      1610       1620       1630       1640       1650
LEWIQHCARK RQEPSTTLDS DEDSPLVTLS FALCTLGRRA LGTAAHNMAI 
      1660       1670       1680       1690       1700
SLDSFLYGLH VLFKGDFRIT ARDEWVFADM DLLHKVVAPA IRMSLKLHQD 
      1710       1720       1730       1740       1750
QFTCPDEYED PAVLYEAIQS FEKKVVICHE GDPAWRGAVL SNKEELLTLR 
      1760       1770       1780       1790       1800
HVVDEGADEY KVIMLHRSFL SFKVIKVNKE CVRGLWAGQQ QELIFLRNRN 
      1810       1820       1830       1840       1850
PERGSIQNNK QVLRNLINSS CDQPLGYPMY VSPLTTSYLG THRQLKNIWG 
      1860       1870       1880       1890       1900
GPITLDRIRT WFWTKWVRMR KDCNARQHSG GNIEDVDGGG APTTGGNNAP 
      1910       1920       1930       1940       1950
SGGSQESSAE QPRKGGAQHG VSSCEGTQRT GRRKGRSQSV QAHSALSQRP 
      1960       1970       1980       1990       2000
PMLSSSGPIL ESRQTFLQTS TSVHELAQRL SGSRLSLHAS ATSLHSQPPP 
      2010       2020       2030       2040       2050
VTTTGHLSVR ERAEALIRSS LGSSTSSTLS FLFGKRSFSS ALVISGLSAA 
      2060       2070       2080       2090       2100
EGGNTSDTQS SSSVNIVMGP SARAASQATR HLSEPCEPPD ATEQGQLHDR 
      2110       2120       2130 
CLAEAVADTL GVVCRRASQE DMGLDDTASQ QSVSDEQ
Length:2,137
Mass (Da):237,277
Last modified:May 20, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i064D91B62BF84E44
GO
Isoform 2 (identifier: A6NKB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-701: Missing.
     955-987: VFLYCFPAISLLGLFPQINTFCTYLLEQIDMLF → GKIMNSHKDFFTSEKKKDKIISAISSVIFLKSW
     988-2137: Missing.

Show »
Length:286
Mass (Da):32,206
Checksum:i6C2E4681ED159F22
GO
Isoform 3 (identifier: A6NKB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1348: Missing.
     1349-1359: RPVKFWEKNYN → MTFYPFVASSS
     2081-2137: HLSEPCEPPD...ASQQSVSDEQ → VRGWAGLTRT...PIPFSMGLPE

Show »
Length:777
Mass (Da):86,628
Checksum:i35E12F71B1BCE69E
GO
Isoform 5 (identifier: A6NKB5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-867: Missing.
     1280-1288: LGDLLHKLQ → VFLGYVRQK
     1289-2137: Missing.

Show »
Length:421
Mass (Da):48,009
Checksum:iD6C30F9210A8A1C8
GO
Isoform 4 (identifier: A6NKB5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1462: Missing.

Show »
Length:675
Mass (Da):75,024
Checksum:i80B564005A8ED96E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSK9A0A0A0MSK9_HUMAN
Pecanex-like protein
PCNX2
412Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVZ6E7EVZ6_HUMAN
Pecanex-like protein
PCNX2
424Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV6H0YAV6_HUMAN
Pecanex-like protein
PCNX2
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB15H0YB15_HUMAN
Pecanex-like protein
PCNX2
490Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBD1H0YBD1_HUMAN
Pecanex-like protein
PCNX2
181Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAR6H0YAR6_HUMAN
Pecanex-like protein
PCNX2
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB30H0YB30_HUMAN
Pecanex-like protein
PCNX2
47Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBF4H0YBF4_HUMAN
Pecanex-like protein
PCNX2
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBD6H0YBD6_HUMAN
Pecanex-like protein
PCNX2
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23708 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84904 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050479117R → K. Corresponds to variant dbSNP:rs1033325Ensembl.1
Natural variantiVAR_043341454T → A. Corresponds to variant dbSNP:rs10910120Ensembl.1
Natural variantiVAR_0614981901S → N1 PublicationCorresponds to variant dbSNP:rs56231757Ensembl.1
Natural variantiVAR_0614991984R → Q. Corresponds to variant dbSNP:rs41309639Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0336051 – 1462Missing in isoform 4. 1 PublicationAdd BLAST1462
Alternative sequenceiVSP_0336061 – 1348Missing in isoform 3. 1 PublicationAdd BLAST1348
Alternative sequenceiVSP_0350481 – 867Missing in isoform 5. 1 PublicationAdd BLAST867
Alternative sequenceiVSP_0336071 – 701Missing in isoform 2. 1 PublicationAdd BLAST701
Alternative sequenceiVSP_033608955 – 987VFLYC…IDMLF → GKIMNSHKDFFTSEKKKDKI ISAISSVIFLKSW in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_033609988 – 2137Missing in isoform 2. 1 PublicationAdd BLAST1150
Alternative sequenceiVSP_0350491280 – 1288LGDLLHKLQ → VFLGYVRQK in isoform 5. 1 Publication9
Alternative sequenceiVSP_0350501289 – 2137Missing in isoform 5. 1 PublicationAdd BLAST849
Alternative sequenceiVSP_0336101349 – 1359RPVKFWEKNYN → MTFYPFVASSS in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0336112081 – 2137HLSEP…VSDEQ → VRGWAGLTRTGWDGGTGSWP ERGTCLAFPPFCLQNPIPFS MGLPE in isoform 3. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB007895 mRNA Translation: BAA23708.2 Different initiation.
AK074078 mRNA Translation: BAB84904.1 Different initiation.
AK021445 mRNA Translation: BAB13826.1
AL139342, AL122003, AL133289 Genomic DNA Translation: CAI18866.1
AL133291 Genomic DNA No translation available.
AL133380 Genomic DNA No translation available.
AL139342 Genomic DNA Translation: CAI18867.1
AL122003, AL139342, AL133289 Genomic DNA Translation: CAI22240.1
AL122003, AL133289 Genomic DNA Translation: CAI22241.1
AL133289, AL139342, AL122003 Genomic DNA Translation: CAI22872.1
AL133289, AL122003 Genomic DNA Translation: CAI22873.1
AL359819 Genomic DNA No translation available.
BC008300 mRNA Translation: AAH08300.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44335.1 [A6NKB5-1]

NCBI Reference Sequences

More...RefSeqi		NP_055616.3, NM_014801.3 [A6NKB5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258229; ENSP00000258229; ENSG00000135749 [A6NKB5-1]
ENST00000344698; ENSP00000340759; ENSG00000135749 [A6NKB5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80003

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80003

UCSC genome browser

More...UCSCi		uc001hvk.1, human [A6NKB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007895 mRNA Translation: BAA23708.2 Different initiation.
AK074078 mRNA Translation: BAB84904.1 Different initiation.
AK021445 mRNA Translation: BAB13826.1
AL139342, AL122003, AL133289 Genomic DNA Translation: CAI18866.1
AL133291 Genomic DNA No translation available.
AL133380 Genomic DNA No translation available.
AL139342 Genomic DNA Translation: CAI18867.1
AL122003, AL139342, AL133289 Genomic DNA Translation: CAI22240.1
AL122003, AL133289 Genomic DNA Translation: CAI22241.1
AL133289, AL139342, AL122003 Genomic DNA Translation: CAI22872.1
AL133289, AL122003 Genomic DNA Translation: CAI22873.1
AL359819 Genomic DNA No translation available.
BC008300 mRNA Translation: AAH08300.2
CCDSiCCDS44335.1 [A6NKB5-1]
RefSeqiNP_055616.3, NM_014801.3 [A6NKB5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123060, 8 interactors
IntActiA6NKB5, 4 interactors
STRINGi9606.ENSP00000258229

PTM databases

GlyGeniA6NKB5, 11 sites
iPTMnetiA6NKB5
PhosphoSitePlusiA6NKB5

Genetic variation databases

BioMutaiPCNX2

Proteomic databases

jPOSTiA6NKB5
PaxDbiA6NKB5
PeptideAtlasiA6NKB5
PRIDEiA6NKB5
ProteomicsDBi1391 [A6NKB5-1]
1392 [A6NKB5-2]
1393 [A6NKB5-3]
1394 [A6NKB5-4]
1395 [A6NKB5-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11747, 49 antibodies

Genome annotation databases

EnsembliENST00000258229; ENSP00000258229; ENSG00000135749 [A6NKB5-1]
ENST00000344698; ENSP00000340759; ENSG00000135749 [A6NKB5-3]
GeneIDi80003
KEGGihsa:80003
UCSCiuc001hvk.1, human [A6NKB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80003
DisGeNETi80003

GeneCards: human genes, protein and diseases

More...GeneCardsi		PCNX2
HGNCiHGNC:8736, PCNX2
HPAiENSG00000135749, Tissue enhanced (brain)
MIMi617656, gene
neXtProtiNX_A6NKB5
OpenTargetsiENSG00000135749
PharmGKBiPA33081
VEuPathDBiHostDB:ENSG00000135749.18

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3604, Eukaryota
GeneTreeiENSGT00940000157374
HOGENOMiCLU_000602_3_0_1
InParanoidiA6NKB5
OMAiMCRRASQ
PhylomeDBiA6NKB5
TreeFamiTF313570

Enzyme and pathway databases

PathwayCommonsiA6NKB5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80003, 5 hits in 864 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PCNX2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80003
PharosiA6NKB5, Tbio

Protein Ontology

More...PROi		PR:A6NKB5
RNActiA6NKB5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135749, Expressed in middle temporal gyrus and 225 other tissues
ExpressionAtlasiA6NKB5, baseline and differential
GenevisibleiA6NKB5, HS

Family and domain databases

InterProiView protein in InterPro
IPR039797, Pecanex
IPR007735, Pecanex_C
PANTHERiPTHR12372, PTHR12372, 1 hit
PfamiView protein in Pfam
PF05041, Pecanex_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NKB5
Secondary accession number(s): O43162
, Q5T9Z8, Q5TDF1, Q8TEP4, Q96HP9, Q9HAL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 10, 2021
This is version 107 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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