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Protein

Ras association domain-containing protein 10

Gene

RASSF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in regulating embryonic neurogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 10
Gene namesi
Name:RASSF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000189431.7
HGNCiHGNC:33984 RASSF10
MIMi614713 gene
neXtProtiNX_A6NK89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi644943
OpenTargetsiENSG00000189431

Polymorphism and mutation databases

BioMutaiRASSF10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322841 – 507Ras association domain-containing protein 10Add BLAST507

Proteomic databases

PRIDEiA6NK89
ProteomicsDBi1387

PTM databases

iPTMnetiA6NK89
PhosphoSitePlusiA6NK89

Expressioni

Tissue specificityi

Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.1 Publication

Gene expression databases

BgeeiENSG00000189431 Expressed in 104 organ(s), highest expression level in metanephros
CleanExiHS_RASSF10
GenevisibleiA6NK89 HS

Organism-specific databases

HPAiHPA040406

Interactioni

Protein-protein interaction databases

BioGridi570026, 38 interactors
IntActiA6NK89, 61 interactors

Structurei

3D structure databases

ProteinModelPortaliA6NK89
SMRiA6NK89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 133Ras-associatingPROSITE-ProRule annotationAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili237 – 264Sequence analysisAdd BLAST28
Coiled coili319 – 358Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi197 – 221Ser-richAdd BLAST25

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00510000047164
HOGENOMiHOG000065674
HOVERGENiHBG053178
InParanoidiA6NK89
KOiK09856
OMAiKSCPGND
OrthoDBiEOG091G09E9
PhylomeDBiA6NK89

Family and domain databases

InterProiView protein in InterPro
IPR033593 N-RASSF
IPR000159 RA_dom
IPR033634 RASSF10
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR15286 PTHR15286, 1 hit
PTHR15286:SF13 PTHR15286:SF13, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit

Sequencei

Sequence statusi: Complete.

A6NK89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPSEKKISV WICQEEKLVS GLSRRTTCSD VVRVLLEDGC RRRRRQRRSR
60 70 80 90 100
RLGSAGDPHG PGELPEPPNE DDEDDDEALP QGMLCGPPQC YCIVEKWRGF
110 120 130 140 150
ERILPNKTRI LRLWAAWGEE QENVRFVLVR SEASLPNAGP RSAEARVVLS
160 170 180 190 200
RERPCPARGA PARPSLAMTQ EKQRRVVRKA FRKLAKLNRR RQQQTPSSCS
210 220 230 240 250
STSSSTASSC SSSPRTHESA SVERMETLVH LVLSQDHTIR QQVQRLHELD
260 270 280 290 300
REIDHYEAKV HLDRMRRHGV NYVQDTYLVG AGIELDGSRP GEEPEEVAAE
310 320 330 340 350
AEEAAAAPPL AGEAQAAALE ELARRCDDLL RLQEQRVQQE ELLERLSAEI
360 370 380 390 400
QEELNQRWMR RRQEELAARE EPLEPDGGPD GELLLEQERV RTQLSTSLYI
410 420 430 440 450
GLRLNTDLEA VKSDLDYSQQ QWDSKKRELQ GLLQTLHTLE LTVAPDGAPG
460 470 480 490 500
SGSPSREPGP QACADMWVDQ ARGLAKSGPG NDEDSDTGLS SMHSQDSDSL

PMCESLV
Length:507
Mass (Da):56,900
Last modified:April 29, 2008 - v3
Checksum:iA9A5D0A546F61518
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042999194Q → H. Corresponds to variant dbSNP:rs4323847Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084859 Genomic DNA No translation available.
CCDSiCCDS44542.2
RefSeqiNP_001073990.2, NM_001080521.2
UniGeneiHs.134650

Genome annotation databases

EnsembliENST00000529419; ENSP00000485526; ENSG00000189431
GeneIDi644943
KEGGihsa:644943
UCSCiuc021qdz.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084859 Genomic DNA No translation available.
CCDSiCCDS44542.2
RefSeqiNP_001073990.2, NM_001080521.2
UniGeneiHs.134650

3D structure databases

ProteinModelPortaliA6NK89
SMRiA6NK89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi570026, 38 interactors
IntActiA6NK89, 61 interactors

PTM databases

iPTMnetiA6NK89
PhosphoSitePlusiA6NK89

Polymorphism and mutation databases

BioMutaiRASSF10

Proteomic databases

PRIDEiA6NK89
ProteomicsDBi1387

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529419; ENSP00000485526; ENSG00000189431
GeneIDi644943
KEGGihsa:644943
UCSCiuc021qdz.2 human

Organism-specific databases

CTDi644943
DisGeNETi644943
EuPathDBiHostDB:ENSG00000189431.7
GeneCardsiRASSF10
HGNCiHGNC:33984 RASSF10
HPAiHPA040406
MIMi614713 gene
neXtProtiNX_A6NK89
OpenTargetsiENSG00000189431
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000047164
HOGENOMiHOG000065674
HOVERGENiHBG053178
InParanoidiA6NK89
KOiK09856
OMAiKSCPGND
OrthoDBiEOG091G09E9
PhylomeDBiA6NK89

Miscellaneous databases

GenomeRNAii644943
PROiPR:A6NK89
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189431 Expressed in 104 organ(s), highest expression level in metanephros
CleanExiHS_RASSF10
GenevisibleiA6NK89 HS

Family and domain databases

InterProiView protein in InterPro
IPR033593 N-RASSF
IPR000159 RA_dom
IPR033634 RASSF10
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR15286 PTHR15286, 1 hit
PTHR15286:SF13 PTHR15286:SF13, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASFA_HUMAN
AccessioniPrimary (citable) accession number: A6NK89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 7, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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