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Protein

RIMS-binding protein 3C

Gene

RIMBP3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-95 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
RIMS-binding protein 3C
Short name:
RIM-BP3.C
Alternative name(s):
RIMS-binding protein 3.3
Short name:
RIM-BP3.3
Gene namesi
Name:RIMBP3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000183246.6
HGNCiHGNC:33892 RIMBP3C
MIMi612701 gene
neXtProtiNX_A6NJZ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183246

Polymorphism and mutation databases

BioMutaiRIMBP3C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322751 – 1639RIMS-binding protein 3CAdd BLAST1639

Proteomic databases

EPDiA6NJZ7
MaxQBiA6NJZ7
PaxDbiA6NJZ7
PRIDEiA6NJZ7
ProteomicsDBi1366

PTM databases

iPTMnetiA6NJZ7
PhosphoSitePlusiA6NJZ7

Expressioni

Gene expression databases

BgeeiENSG00000183246
CleanExiHS_RIMBP3C
ExpressionAtlasiA6NJZ7 baseline
GenevisibleiA6NJZ7 HS

Organism-specific databases

HPAiHPA001183

Interactioni

Subunit structurei

Interacts with FASLG.1 Publication

Protein-protein interaction databases

BioGridi127271, 1 interactor
IntActiA6NJZ7, 1 interactor
STRINGi9606.ENSP00000390630

Structurei

3D structure databases

ProteinModelPortaliA6NJZ7
SMRiA6NJZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini832 – 899SH3 1PROSITE-ProRule annotationAdd BLAST68
Domaini995 – 1083Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini1088 – 1184Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini1452 – 1520SH3 2PROSITE-ProRule annotationAdd BLAST69
Domaini1569 – 1636SH3 3PROSITE-ProRule annotationAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 143Sequence analysisAdd BLAST123
Coiled coili409 – 442Sequence analysisAdd BLAST34
Coiled coili480 – 619Sequence analysisAdd BLAST140

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 137Arg-richAdd BLAST108
Compositional biasi312 – 366Pro-richAdd BLAST55

Sequence similaritiesi

Belongs to the RIMBP family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3632 Eukaryota
ENOG410XZ8W LUCA
GeneTreeiENSGT00390000017228
HOGENOMiHOG000090231
HOVERGENiHBG096074
InParanoidiA6NJZ7
OMAiFREKENC
OrthoDBiEOG091G02RN
PhylomeDBiA6NJZ7
TreeFamiTF316230

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035515 Rimbp3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14234:SF21 PTHR14234:SF21, 2 hits
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00326 SH3, 3 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50002 SH3, 3 hits

Sequencei

Sequence statusi: Complete.

A6NJZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE
60 70 80 90 100
RRRFAARERQ LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE
110 120 130 140 150
AEIRQLLRWK EAEQRQLQQL LHRERDGVVR QARELQRQLA EELVNRGHCS
160 170 180 190 200
RPGASEVSAA QCRCRLQEVL AQLRWQTDGE QAARIRYLQA ALEVERQLFL
210 220 230 240 250
KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP KPACQLGSLD
260 270 280 290 300
SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR
310 320 330 340 350
SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG
360 370 380 390 400
EGSESQPCEV LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQEENKQ
410 420 430 440 450
LRRAGCPYQA DEKVKRLKVK RAELTGLARR LADRARELQE TNLRAVSAPI
460 470 480 490 500
PGESCAGLEL CQVFARQRAR DLSEQASAPL AKDKQIEELR QECHLLQARV
510 520 530 540 550
ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ RQLMLQQGNG
560 570 580 590 600
GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGTQ AAPARRRGEE
610 620 630 640 650
AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER
660 670 680 690 700
DASGLIAEQL LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG
710 720 730 740 750
HPPEQPWETS QMPESQVKGS RRPKFHARPE DYAVSQPNRD IQEKREASLE
760 770 780 790 800
ESPVALGESA SVPQVSETVP ASQPLSKKTS SQSNSSSEGS MWATVPSSPT
810 820 830 840 850
LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ YNYNPFEGPN
860 870 880 890 900
DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LDDGRRGLVP SNFVEQIPDS
910 920 930 940 950
YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGMV DRGLCQMVRV
960 970 980 990 1000
GSKTEVATEI LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH
1010 1020 1030 1040 1050
LQNVTATSAN ITWVYSSHRH PHVVYLDDRE HALTPAGVSC YTFQGLCPGT
1060 1070 1080 1090 1100
HYRVRVEVRL PWDLLQVYWG TMSSTVTFDT LLAGPPYPPL DVLVERHASP
1110 1120 1130 1140 1150
GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD ATAGSTVLEF
1160 1170 1180 1190 1200
SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT
1210 1220 1230 1240 1250
CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP
1260 1270 1280 1290 1300
PRRQSPVSNL GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP
1310 1320 1330 1340 1350
PSVSDQPGEK ENCYQHMGTS KSPAPGFIHL RTECGPRKEP CQEKAALERV
1360 1370 1380 1390 1400
LRQKQDAQGF TPPQLGASQQ YASDFHNVLK EEQEALCLDL RGTERREERR
1410 1420 1430 1440 1450
EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR GGPQQLGTGA
1460 1470 1480 1490 1500
NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL
1510 1520 1530 1540 1550
SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGHLPSV AHLEDFQGLI
1560 1570 1580 1590 1600
IPQGSSLVLQ GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG
1610 1620 1630
DVVMVYGPMD DQGFYYGELG GHRGLVPAHL LDHMSLHGH
Length:1,639
Mass (Da):180,950
Last modified:March 21, 2012 - v3
Checksum:iA91AA22674EA0F26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000557 Genomic DNA No translation available.
CCDSiCCDS46669.1
RefSeqiNP_001122105.1, NM_001128633.1
UniGeneiHs.447643

Genome annotation databases

EnsembliENST00000433039; ENSP00000390630; ENSG00000183246
GeneIDi150221
KEGGihsa:150221
UCSCiuc002zuy.5 human

Similar proteinsi

Entry informationi

Entry nameiRIM3C_HUMAN
AccessioniPrimary (citable) accession number: A6NJZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2012
Last modified: June 20, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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