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Entry version 76 (08 May 2019)
Sequence version 4 (08 Mar 2011)
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Protein

Nuclear pore complex-interacting protein family member B13

Gene

NPIPB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex-interacting protein family member B13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPIPB13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:41989 NPIPB13

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NJU9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei73 – 93HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NPIPB13

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003436651 – 1138Nuclear pore complex-interacting protein family member B13Add BLAST1138

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NJU9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NJU9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NJU9

PRoteomics IDEntifications database

More...
PRIDEi
A6NJU9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1356

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198064 Expressed in 93 organ(s), highest expression level in prefrontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NJU9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NJU9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NJU9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 1132Pro-richPROSITE-ProRule annotationAdd BLAST886

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPIP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0WZ Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00540000072033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293160

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACCLHRR

Database of Orthologous Groups

More...
OrthoDBi
119185at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NJU9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009443 NPIP

The PANTHER Classification System

More...
PANTHERi
PTHR15438 PTHR15438, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A6NJU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH
60 70 80 90 100
RGTDFGGSPW LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS
110 120 130 140 150
TDVQQRAWRS NRRRQEGLRS ICMHTKKRVS SFRGNKIGLK DVITLRRHVE
160 170 180 190 200
TKVRAKIRKR KVTTKINHHD KINGKRKTAR KQKMFQRAQE LRRRAEDYHK
210 220 230 240 250
CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK NRMGHQPPPP
260 270 280 290 300
TQQHSITDNS LSLKTPPECV LTPLPPSADD NLKTPPECVL TPLPPSADDN
310 320 330 340 350
LKTPPECLLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL
360 370 380 390 400
PPSAPPSAPP SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA
410 420 430 440 450
PPSADDNIKT PAERLRGPLP PSADDNLKTP SERQLTPLPP SAPPSADDNI
460 470 480 490 500
KTPAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR
510 520 530 540 550
GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD
560 570 580 590 600
DNLKTPSERQ LTPLPPSAPP SADDNIKTPA FHPQRMIISR HLPSVSSLPF
610 620 630 640 650
HPQLHSQQMI ISRYLLSVCG FRFHHQPMII SRHLPSVSSL PFHPQLHPQQ
660 670 680 690 700
MIISRHLPSV CGGRFHPQRM IISRHLPSVS SLPFHPQLHP QQMIISRHLP
710 720 730 740 750
SVCGGRFHPQ RMIISRHLPS VSSLPFHPQL HPQQMIISRH LPSVCGERLR
760 770 780 790 800
GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRRPLPPSAD
810 820 830 840 850
DNLKTPSERQ LTPLPPSAPP SADDNIKTPA ERLRGPLPPS ADDNLKTPSE
860 870 880 890 900
RQLTPLPPSA PPSADDNIKT PAERLRGPLP PSADDNLKTP SERQLTPLPP
910 920 930 940 950
SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD
960 970 980 990 1000
NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER
1010 1020 1030 1040 1050
LRGPLPPSAD DNLKTPPLAT QEAEAEKPRK PKRQRAAEME PPPEPKRRRV
1060 1070 1080 1090 1100
GDVEPSRKPK RRRAADVEPS SPKPKRRRVG DVEPSRKPKR RRAADVEPSS
1110 1120 1130
PEPKRRRVGD VEPSRKPKRR RAADVEPSSP EPKRRRLS
Length:1,138
Mass (Da):125,964
Last modified:March 8, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5FB190502A78C8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHP9E5RHP9_HUMAN
Nuclear pore complex-interacting pr...
NPIPB5 NPIPB12, NPIPB13, NPIPB4
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWQ4F5GWQ4_HUMAN
Nuclear pore complex-interacting pr...
NPIPB5 NPIPB12, NPIPB13, NPIPB4
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GW90F5GW90_HUMAN
Nuclear pore complex-interacting pr...
NPIPB13
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQU5H3BQU5_HUMAN
Nuclear pore complex-interacting pr...
NPIPB13
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P7U241A0A1P7U241_HUMAN
Nuclear pore complex-interacting pr...
NPIPB13
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC106782 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81968.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308821.1, NM_001321892.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000520915; ENSP00000429734; ENSG00000198064

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
613037

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:613037

UCSC genome browser

More...
UCSCi
uc010vem.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106782 Genomic DNA No translation available.
CCDSiCCDS81968.1
RefSeqiNP_001308821.1, NM_001321892.1

3D structure databases

SMRiA6NJU9
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiNPIPB13

Proteomic databases

EPDiA6NJU9
jPOSTiA6NJU9
PaxDbiA6NJU9
PRIDEiA6NJU9
ProteomicsDBi1356

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000520915; ENSP00000429734; ENSG00000198064
GeneIDi613037
KEGGihsa:613037
UCSCiuc010vem.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
613037

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NPIPB13
HGNCiHGNC:41989 NPIPB13
HPAiHPA053611
neXtProtiNX_A6NJU9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0WZ Eukaryota
COG5069 LUCA
GeneTreeiENSGT00540000072033
HOGENOMiHOG000293160
OMAiACCLHRR
OrthoDBi119185at2759
PhylomeDBiA6NJU9

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
613037

Protein Ontology

More...
PROi
PR:A6NJU9

Gene expression databases

BgeeiENSG00000198064 Expressed in 93 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiA6NJU9 baseline and differential
GenevisibleiA6NJU9 HS

Family and domain databases

InterProiView protein in InterPro
IPR009443 NPIP
PANTHERiPTHR15438 PTHR15438, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPB13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NJU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 8, 2011
Last modified: May 8, 2019
This is version 76 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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