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Protein

Homeobox protein unc-4 homolog

Gene

UNCX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi105 – 164HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein unc-4 homolog
Alternative name(s):
Homeobox protein Uncx4.1
Gene namesi
Name:UNCX
Synonyms:UNCX4.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164853.8
HGNCiHGNC:33194 UNCX
neXtProtiNX_A6NJT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164853
PharmGKBiPA162408642

Polymorphism and mutation databases

BioMutaiUNCX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346241 – 531Homeobox protein unc-4 homologAdd BLAST531

Proteomic databases

EPDiA6NJT0
MaxQBiA6NJT0
PaxDbiA6NJT0
PRIDEiA6NJT0
ProteomicsDBi1352

PTM databases

iPTMnetiA6NJT0
PhosphoSitePlusiA6NJT0

Expressioni

Gene expression databases

BgeeiENSG00000164853
CleanExiHS_UNCX

Organism-specific databases

HPAiHPA063294

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314480

Structurei

3D structure databases

ProteinModelPortaliA6NJT0
SMRiA6NJT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 523Ala/Pro-richAdd BLAST280

Sequence similaritiesi

Belongs to the paired homeobox family. Unc-4 subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000154780
HOVERGENiHBG096185
InParanoidiA6NJT0
KOiK09328
OMAiSCDQTPH
OrthoDBiEOG091G0B1L
PhylomeDBiA6NJT0
TreeFamiTF315554

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NJT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAASV
60 70 80 90 100
PFSIDGLLGG SCAAAASVVN PTPLLPAACG VGGDGQPFKL SDSGDPDKES
110 120 130 140 150
PGCKRRRTRT NFTGWQLEEL EKAFNESHYP DVFMREALAL RLDLVESRVQ
160 170 180 190 200
VWFQNRRAKW RKKENTKKGP GRPAHNSHPT TCSGEPMDPE EIARKELEKM
210 220 230 240 250
EKKKRKHEKK LLKSQGRHLH SPGGLSLHSA PSSDSDSGGG GLSPEPPEPP
260 270 280 290 300
PPAAKGPGAH ASGAAGTAPA PPGEPPAPGT CDPAFYPSQR SGAGPQPRPG
310 320 330 340 350
RPADKDAASC GPGAAVAAVE RGAAGLPKAS PFSVESLLSD SPPRRKAASN
360 370 380 390 400
AAAAAAAGLD FAPGLPCAPR TLIGKGHFLL YPITQPLGFL VPQAALKGGA
410 420 430 440 450
GLEPAPKDAP PAPAVPPAPP AQASFGAFSG PGGAPDSAFA RRSPDAVASP
460 470 480 490 500
GAPAPAPAPF RDLASAAATE GGGGDCADAG TAGPAPPPPA PSPRPGPRPP
510 520 530
SPAEEPATCG VPEPGAAAGP SPPEGEELDM D
Length:531
Mass (Da):53,690
Last modified:July 24, 2007 - v1
Checksum:iF538F74E77D7F32E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073094 Genomic DNA No translation available.
CH236953 Genomic DNA Translation: EAL23940.1 Sequence problems.
CCDSiCCDS34583.1
RefSeqiNP_001073930.1, NM_001080461.1

Genome annotation databases

EnsembliENST00000316333; ENSP00000314480; ENSG00000164853
GeneIDi340260
KEGGihsa:340260
UCSCiuc011jvw.3 human

Similar proteinsi

Entry informationi

Entry nameiUNC4_HUMAN
AccessioniPrimary (citable) accession number: A6NJT0
Secondary accession number(s): A4D221
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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