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Protein

Arginine-fifty homeobox

Gene

ARGFX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi78 – 137HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-fifty homeobox
Gene namesi
Name:ARGFX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000186103.3
HGNCiHGNC:30146 ARGFX
MIMi611164 gene
neXtProtiNX_A6NJG6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186103
PharmGKBiPA142672588

Polymorphism and mutation databases

BioMutaiARGFX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113251 – 315Arginine-fifty homeoboxAdd BLAST315

Proteomic databases

EPDiA6NJG6
PaxDbiA6NJG6
PRIDEiA6NJG6
ProteomicsDBi1335
TopDownProteomicsiA6NJG6

PTM databases

iPTMnetiA6NJG6
PhosphoSitePlusiA6NJG6

Expressioni

Tissue specificityi

Expressed at low level in testis and undifferentiated embryonic stem cells.1 Publication

Gene expression databases

BgeeiENSG00000186103
CleanExiHS_ARGFX

Organism-specific databases

HPAiHPA043049

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335578

Structurei

3D structure databases

ProteinModelPortaliA6NJG6
SMRiA6NJG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00730000111572
HOGENOMiHOG000034042
InParanoidiA6NJG6
OMAiMQDTQWE
OrthoDBiEOG091G0DAL
PhylomeDBiA6NJG6
TreeFamiTF351179

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NJG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA
60 70 80 90 100
YCSLNLPGST DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT
110 120 130 140 150
MFPDRNLQEK LALRLDLPES TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP
160 170 180 190 200
SKKNVPTSPR TSPSPYAFSP VISDFYSSLP SQPLDPSNWA WNSTFTESST
210 220 230 240 250
SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN EISSSSFHCL
260 270 280 290 300
YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS
310
LEFQKTSNMV DLGFL
Length:315
Mass (Da):35,617
Last modified:July 24, 2007 - v1
Checksum:iD3EDBA45BAB43352
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037226145R → Q. Corresponds to variant dbSNP:rs9813391Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069239 Genomic DNA No translation available.
CCDSiCCDS33834.1
RefSeqiNP_001012677.1, NM_001012659.1
UniGeneiHs.224976

Genome annotation databases

EnsembliENST00000334384; ENSP00000335578; ENSG00000186103
GeneIDi503582
KEGGihsa:503582
UCSCiuc062myc.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARGFX_HUMAN
AccessioniPrimary (citable) accession number: A6NJG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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