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Entry version 103 (13 Feb 2019)
Sequence version 1 (24 Jul 2007)
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Protein

Probable methyltransferase-like protein 15

Gene

METTL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119S-adenosyl-L-methionineBy similarity1
Binding sitei146S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei169S-adenosyl-L-methionineBy similarity1
Binding sitei176S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • rRNA (cytosine-N4-)-methyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable methyltransferase-like protein 15 (EC:2.1.1.-)
Alternative name(s):
Methyltransferase 5 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:METTL15
Synonyms:METT5D1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169519.20

Human Gene Nomenclature Database

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HGNCi
HGNC:26606 METTL15

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NJ78

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000169519

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671458

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
METTL15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003083321 – 407Probable methyltransferase-like protein 15Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A6NJ78

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A6NJ78

MaxQB - The MaxQuant DataBase

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MaxQBi
A6NJ78

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A6NJ78

PRoteomics IDEntifications database

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PRIDEi
A6NJ78

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1313
1314 [A6NJ78-2]
1315 [A6NJ78-3]
1316 [A6NJ78-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NJ78

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NJ78

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169519 Expressed in 181 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A6NJ78 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A6NJ78 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039885

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156455EBI-10174029,EBI-358993

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128190, 22 interactors

Protein interaction database and analysis system

More...
IntActi
A6NJ78, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384369

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A6NJ78

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni100 – 102S-adenosyl-L-methionine bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2782 Eukaryota
COG0275 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014756

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055013

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NJ78

Identification of Orthologs from Complete Genome Data

More...
OMAi
VMRVAEK

Database of Orthologous Groups

More...
OrthoDBi
809593at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NJ78

TreeFam database of animal gene trees

More...
TreeFami
TF106425

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.170, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01007 16SrRNA_methyltr_H, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002903 RsmH
IPR023397 SAM-dep_MeTrfase_MraW_recog
IPR029063 SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR11265 PTHR11265, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01795 Methyltransf_5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit
SSF81799 SSF81799, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00006 TIGR00006, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NJ78-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRYPYFCRM YKECLSCWLE SGIPNLGVWP NRIHTTAEKY REYEAREQTD
60 70 80 90 100
QTQAQELHRS QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG
110 120 130 140 150
GHTKAILQKE SDIVLYALDR DPTAYALAEH LSELYPKQIR AMLGQFSQAE
160 170 180 190 200
ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP ERGFSLRKDG PLDMRMDGGR
210 220 230 240 250
YPDMPTAADV VNALDQQALA SILRTYGEEK HAKKIASAIV QARSIYPITR
260 270 280 290 300
TQQLASIVAG AFPPSAIYTR KDLLQRSTHI ATKTFQALRI FVNNELNELY
310 320 330 340 350
TGLKTAQKFL RPGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSVRQQV
360 370 380 390 400
MKTSQLGSDH ENTEEVSMRR APLMWELIHK KVLSPQDQDV QDNPRGRSAK

LRAAIKL
Length:407
Mass (Da):46,121
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DA02B5842483080
GO
Isoform 2 (identifier: A6NJ78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-273: GAFPPSAIYTRKDL → EYSETYFPVAQTLY
     274-407: Missing.

Show »
Length:273
Mass (Da):30,872
Checksum:i71BBA524769D6066
GO
Isoform 3 (identifier: A6NJ78-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-99: IFLDMTFGS → SLGVRSVGI
     100-407: Missing.

Show »
Length:99
Mass (Da):11,631
Checksum:i0A6B26342AB079D8
GO
Isoform 4 (identifier: A6NJ78-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-320: YPDMPTAADV...RPGGRLVALS → STGTCIYPKN...FPGSSHICEQ
     321-407: Missing.

Show »
Length:279
Mass (Da):31,700
Checksum:iB698284087F05A6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WD83F8WD83_HUMAN
Probable methyltransferase-like pro...
METTL15
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR76A0A0U1RR76_HUMAN
Probable methyltransferase-like pro...
METTL15
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC64B5MC64_HUMAN
Probable methyltransferase-like pro...
METTL15
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR64A0A0U1RR64_HUMAN
Probable methyltransferase-like pro...
METTL15
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRD2A0A0U1RRD2_HUMAN
Probable methyltransferase-like pro...
METTL15
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRF2A0A0U1RRF2_HUMAN
Probable methyltransferase-like pro...
METTL15
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191P → S in AAH30997 (PubMed:15489334).Curated1
Sequence conflicti194M → V in BAC03631 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03680131N → K2 PublicationsCorresponds to variant dbSNP:rs2883478Ensembl.1
Natural variantiVAR_036802149A → T. Corresponds to variant dbSNP:rs11823114Ensembl.1
Natural variantiVAR_059446267I → F. Corresponds to variant dbSNP:rs11030280Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02897091 – 99IFLDMTFGS → SLGVRSVGI in isoform 3. 1 Publication9
Alternative sequenceiVSP_028971100 – 407Missing in isoform 3. 1 PublicationAdd BLAST308
Alternative sequenceiVSP_028972201 – 320YPDMP…LVALS → STGTCIYPKNIRGGEACQEN RFSNCSGTQHLPHHQNPAAC QHRCRSISSLCYLYTERLTT AIYPYCHQDFPGSSHICEQ in isoform 4. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_028973260 – 273GAFPP…TRKDL → EYSETYFPVAQTLY in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_028974274 – 407Missing in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_028975321 – 407Missing in isoform 4. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK091298 mRNA Translation: BAC03631.1
AC023206 Genomic DNA No translation available.
AC087376 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68267.1
CH471064 Genomic DNA Translation: EAW68266.1
BC030997 mRNA Translation: AAH30997.1 Different initiation.
BC105287 mRNA Translation: AAI05288.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31450.1 [A6NJ78-2]
CCDS44559.1 [A6NJ78-1]
CCDS73269.1 [A6NJ78-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001107000.1, NM_001113528.1 [A6NJ78-1]
NP_001284704.1, NM_001297775.1 [A6NJ78-4]
NP_689849.2, NM_152636.2 [A6NJ78-2]
XP_016872786.1, XM_017017297.1 [A6NJ78-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.243326
Hs.539002
Hs.684649

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303459; ENSP00000307251; ENSG00000169519 [A6NJ78-2]
ENST00000406787; ENSP00000385507; ENSG00000169519 [A6NJ78-4]
ENST00000407364; ENSP00000384369; ENSG00000169519 [A6NJ78-1]
ENST00000437814; ENSP00000392806; ENSG00000169519 [A6NJ78-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
196074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:196074

UCSC genome browser

More...
UCSCi
uc001mse.3 human [A6NJ78-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091298 mRNA Translation: BAC03631.1
AC023206 Genomic DNA No translation available.
AC087376 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68267.1
CH471064 Genomic DNA Translation: EAW68266.1
BC030997 mRNA Translation: AAH30997.1 Different initiation.
BC105287 mRNA Translation: AAI05288.1
CCDSiCCDS31450.1 [A6NJ78-2]
CCDS44559.1 [A6NJ78-1]
CCDS73269.1 [A6NJ78-4]
RefSeqiNP_001107000.1, NM_001113528.1 [A6NJ78-1]
NP_001284704.1, NM_001297775.1 [A6NJ78-4]
NP_689849.2, NM_152636.2 [A6NJ78-2]
XP_016872786.1, XM_017017297.1 [A6NJ78-1]
UniGeneiHs.243326
Hs.539002
Hs.684649

3D structure databases

ProteinModelPortaliA6NJ78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128190, 22 interactors
IntActiA6NJ78, 15 interactors
STRINGi9606.ENSP00000384369

PTM databases

iPTMnetiA6NJ78
PhosphoSitePlusiA6NJ78

Polymorphism and mutation databases

BioMutaiMETTL15

Proteomic databases

EPDiA6NJ78
jPOSTiA6NJ78
MaxQBiA6NJ78
PaxDbiA6NJ78
PRIDEiA6NJ78
ProteomicsDBi1313
1314 [A6NJ78-2]
1315 [A6NJ78-3]
1316 [A6NJ78-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
196074
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303459; ENSP00000307251; ENSG00000169519 [A6NJ78-2]
ENST00000406787; ENSP00000385507; ENSG00000169519 [A6NJ78-4]
ENST00000407364; ENSP00000384369; ENSG00000169519 [A6NJ78-1]
ENST00000437814; ENSP00000392806; ENSG00000169519 [A6NJ78-3]
GeneIDi196074
KEGGihsa:196074
UCSCiuc001mse.3 human [A6NJ78-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
196074
EuPathDBiHostDB:ENSG00000169519.20

GeneCards: human genes, protein and diseases

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GeneCardsi
METTL15
HGNCiHGNC:26606 METTL15
HPAiHPA039885
neXtProtiNX_A6NJ78
OpenTargetsiENSG00000169519
PharmGKBiPA142671458

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2782 Eukaryota
COG0275 LUCA
GeneTreeiENSGT00390000014756
HOVERGENiHBG055013
InParanoidiA6NJ78
OMAiVMRVAEK
OrthoDBi809593at2759
PhylomeDBiA6NJ78
TreeFamiTF106425

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
METTL15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
196074

Protein Ontology

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PROi
PR:A6NJ78

Gene expression databases

BgeeiENSG00000169519 Expressed in 181 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiA6NJ78 baseline and differential
GenevisibleiA6NJ78 HS

Family and domain databases

Gene3Di1.10.150.170, 1 hit
HAMAPiMF_01007 16SrRNA_methyltr_H, 1 hit
InterProiView protein in InterPro
IPR002903 RsmH
IPR023397 SAM-dep_MeTrfase_MraW_recog
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11265 PTHR11265, 1 hit
PfamiView protein in Pfam
PF01795 Methyltransf_5, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF81799 SSF81799, 1 hit
TIGRFAMsiTIGR00006 TIGR00006, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMET15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NJ78
Secondary accession number(s): A8MRS5
, B7WNU2, Q3MHD3, Q8N601, Q8NBA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 24, 2007
Last modified: February 13, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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