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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Gene

AGAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri479 – 502C4-type; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
Short name:
AGAP-5
Alternative name(s):
Centaurin-gamma-like family member 2
Gene namesi
Name:AGAP5
Synonyms:CTGLF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000172650.12
HGNCiHGNC:23467 AGAP5
neXtProtiNX_A6NIR3

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715123

Polymorphism and mutation databases

BioMutaiAGAP5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492051 – 686Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5Add BLAST686

Proteomic databases

EPDiA6NIR3
MaxQBiA6NIR3
PaxDbiA6NIR3
PRIDEiA6NIR3
ProteomicsDBi1279

PTM databases

iPTMnetiA6NIR3
PhosphoSitePlusiA6NIR3

Expressioni

Gene expression databases

BgeeiENSG00000172650
CleanExiHS_AGAP5
ExpressionAtlasiA6NIR3 baseline and differential
GenevisibleiA6NIR3 HS

Organism-specific databases

HPAiHPA042490

Interactioni

Protein-protein interaction databases

BioGridi609497, 1 interactor
IntActiA6NIR3, 1 interactor
STRINGi9606.ENSP00000363207

Structurei

3D structure databases

ProteinModelPortaliA6NIR3
SMRiA6NIR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini282 – 443PHPROSITE-ProRule annotationAdd BLAST162
Domaini464 – 584Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati623 – 652ANK 1Add BLAST30
Repeati656 – 685ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri479 – 502C4-type; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000007233
HOVERGENiHBG054045
InParanoidiA6NIR3
PhylomeDBiA6NIR3
TreeFamiTF317762

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A6NIR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE
110 120 130 140 150
FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL
160 170 180 190 200
DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH
210 220 230 240 250
ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW
260 270 280 290 300
SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
310 320 330 340 350
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS
360 370 380 390 400
ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK
410 420 430 440 450
KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE
460 470 480 490 500
SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI
510 520 530 540 550
ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG
560 570 580 590 600
QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL
610 620 630 640 650
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV
660 670 680
MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV
Length:686
Mass (Da):75,492
Last modified:January 11, 2011 - v2
Checksum:iC51D1E96C6179B24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8C → R in BC127746 (PubMed:15489334).Curated1
Sequence conflicti365K → E in BC127746 (PubMed:15489334).Curated1
Sequence conflicti482Y → C in BC127746 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073389 Genomic DNA No translation available.
AC022400 Genomic DNA No translation available.
BC127746 mRNA No translation available.
CCDSiCCDS44439.1
RefSeqiNP_001137472.1, NM_001144000.1
UniGeneiHs.651147

Genome annotation databases

EnsembliENST00000374094; ENSP00000363207; ENSG00000172650
GeneIDi729092
KEGGihsa:729092
UCSCiuc009xri.4 human

Similar proteinsi

Entry informationi

Entry nameiAGAP5_HUMAN
AccessioniPrimary (citable) accession number: A6NIR3
Secondary accession number(s): A8MSN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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