AGAP5

Functionⁱ

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	479 – 502	C4-type; degeneratePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 Short name: AGAP-5 Alternative name(s): Centaurin-gamma-like family member 2
Gene namesⁱ	Name:AGAP5 Synonyms:CTGLF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172650.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23467 AGAP5
neXtProtⁱ	NX_A6NIR3

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA164715123

PharmGKBⁱ

PA164715123

Polymorphism and mutation databases

BioMutaⁱ	AGAP5

BioMutaⁱ

AGAP5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000349205	1 – 686	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5Add BLAST		686

Proteomic databases

EPDⁱ	A6NIR3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NIR3
PaxDbⁱ	A6NIR3
PRIDEⁱ	A6NIR3
ProteomicsDBⁱ	1279

PTM databases

iPTMnetⁱ	A6NIR3
PhosphoSitePlusⁱ	A6NIR3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172650
CleanExⁱ	HS_AGAP5
ExpressionAtlasⁱ	A6NIR3 baseline and differential
Genevisibleⁱ	A6NIR3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042490

HPAⁱ

HPA042490

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	609497, 1 interactor
IntActⁱ	A6NIR3, 1 interactor
STRINGⁱ	9606.ENSP00000363207

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NIR3
SMRⁱ	A6NIR3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	282 – 443	PHPROSITE-ProRule annotationAdd BLAST	162
Domainⁱ	464 – 584	Arf-GAPPROSITE-ProRule annotationAdd BLAST	121
Repeatⁱ	623 – 652	ANK 1Add BLAST	30
Repeatⁱ	656 – 685	ANK 2Add BLAST	30

Sequence similaritiesⁱ

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	479 – 502	C4-type; degeneratePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0705 Eukaryota COG5347 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118874
HOGENOMⁱ	HOG000007233
HOVERGENⁱ	HBG054045
InParanoidⁱ	A6NIR3
PhylomeDBⁱ	A6NIR3
TreeFamⁱ	TF317762

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A6NIR3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ 
        60         70         80         90        100
PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE 
       110        120        130        140        150
FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL 
       160        170        180        190        200
DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH 
       210        220        230        240        250
ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW 
       260        270        280        290        300
SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 
       310        320        330        340        350
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS 
       360        370        380        390        400
ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK 
       410        420        430        440        450
KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE 
       460        470        480        490        500
SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI 
       510        520        530        540        550
ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG 
       560        570        580        590        600
QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL 
       610        620        630        640        650
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV 
       660        670        680 
MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV

Length:686

Mass (Da):75,492

Last modified:January 11, 2011 - v2

Checksum:ⁱC51D1E96C6179B24

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	C → R in BC127746 (PubMed:15489334).Curated	1
Sequence conflictⁱ	365	K → E in BC127746 (PubMed:15489334).Curated	1
Sequence conflictⁱ	482	Y → C in BC127746 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073389 Genomic DNA No translation available. AC022400 Genomic DNA No translation available. BC127746 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44439.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001137472.1, NM_001144000.1
UniGeneⁱ	Hs.651147

Genome annotation databases

Ensemblⁱ	ENST00000374094; ENSP00000363207; ENSG00000172650
GeneIDⁱ	729092
KEGGⁱ	hsa:729092
UCSC genome browser More...UCSCⁱ	uc009xri.4 human

Protein	Similar proteins		Species	Score	Length
A6NIR3	UPI000D09B395		PANTR		693
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4		HUMAN		686
Uncharacterized protein		GORGO		555
Q5VTM2-2				658
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5		HUMAN		686
+17

Protein	Similar proteins		Species	Score	Length
A6NIR3	UPI000D09B395		PANTR		693
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4		HUMAN		686
Uncharacterized protein		GORGO		555
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1		SAIBB		866
Q5VTM2-2				658
+18

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073389 Genomic DNA No translation available. AC022400 Genomic DNA No translation available. BC127746 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44439.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001137472.1, NM_001144000.1
UniGeneⁱ	Hs.651147

3D structure databases

ProteinModelPortalⁱ	A6NIR3
SMRⁱ	A6NIR3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	609497, 1 interactor
IntActⁱ	A6NIR3, 1 interactor
STRINGⁱ	9606.ENSP00000363207

PTM databases

iPTMnetⁱ	A6NIR3
PhosphoSitePlusⁱ	A6NIR3

Polymorphism and mutation databases

BioMutaⁱ	AGAP5

BioMutaⁱ

AGAP5

Proteomic databases

EPDⁱ	A6NIR3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NIR3
PaxDbⁱ	A6NIR3
PRIDEⁱ	A6NIR3
ProteomicsDBⁱ	1279

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374094; ENSP00000363207; ENSG00000172650
GeneIDⁱ	729092
KEGGⁱ	hsa:729092
UCSC genome browser More...UCSCⁱ	uc009xri.4 human

Organism-specific databases

CTDⁱ	729092
EuPathDBⁱ	HostDB:ENSG00000172650.12
GeneCardsⁱ	AGAP5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23467 AGAP5
Human Protein Atlas More...HPAⁱ	HPA042490
neXtProtⁱ	NX_A6NIR3
PharmGKBⁱ	PA164715123
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0705 Eukaryota COG5347 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118874
HOGENOMⁱ	HOG000007233
HOVERGENⁱ	HBG054045
InParanoidⁱ	A6NIR3
PhylomeDBⁱ	A6NIR3
TreeFamⁱ	TF317762

Miscellaneous databases

ChiTaRSⁱ	AGAP5 human
GenomeRNAiⁱ	729092
Protein Ontology More...PROⁱ	PR:A6NIR3

Gene expression databases

Bgeeⁱ	ENSG00000172650
CleanExⁱ	HS_AGAP5
ExpressionAtlasⁱ	A6NIR3 baseline and differential
Genevisibleⁱ	A6NIR3 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGAP5_HUMAN
Accessionⁱ	A6NIR3Primary (citable) accession number: A6NIR3 Secondary accession number(s): A8MSN5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	January 11, 2011
	Last modified:	July 18, 2018
	This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6NIR3 (AGAP5_HUMAN)

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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ