UniProtKB - A6NIR3 (AGAP5_HUMAN)
Protein
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
Gene
AGAP5
Organism
Homo sapiens (Human)
Status
Functioni
Putative GTPase-activating protein.Curated
Miscellaneous
Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 479 – 502 | C4-type; degeneratePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A6NIR3 |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5Short name: AGAP-5 Alternative name(s): Centaurin-gamma-like family member 2 |
Gene namesi | Name:AGAP5 Synonyms:CTGLF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172650.12 |
HGNCi | HGNC:23467, AGAP5 |
neXtProti | NX_A6NIR3 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA164715123 |
Miscellaneous databases
Pharosi | A6NIR3, Tdark |
Polymorphism and mutation databases
BioMutai | AGAP5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349205 | 1 – 686 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5Add BLAST | 686 |
Proteomic databases
jPOSTi | A6NIR3 |
MassIVEi | A6NIR3 |
MaxQBi | A6NIR3 |
PaxDbi | A6NIR3 |
PeptideAtlasi | A6NIR3 |
PRIDEi | A6NIR3 |
ProteomicsDBi | 1279 |
PTM databases
iPTMneti | A6NIR3 |
PhosphoSitePlusi | A6NIR3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172650, Expressed in body of pancreas and 112 other tissues |
ExpressionAtlasi | A6NIR3, baseline and differential |
Genevisiblei | A6NIR3, HS |
Organism-specific databases
HPAi | ENSG00000172650, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 609497, 2 interactors |
IntActi | A6NIR3, 2 interactors |
MINTi | A6NIR3 |
STRINGi | 9606.ENSP00000363207 |
Miscellaneous databases
RNActi | A6NIR3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 282 – 443 | PHPROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 464 – 584 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 121 | |
Repeati | 623 – 652 | ANK 1Add BLAST | 30 | |
Repeati | 656 – 685 | ANK 2Add BLAST | 30 |
Sequence similaritiesi
Belongs to the centaurin gamma-like family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 479 – 502 | C4-type; degeneratePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0705, Eukaryota |
GeneTreei | ENSGT00940000163475 |
InParanoidi | A6NIR3 |
OrthoDBi | 751525at2759 |
PhylomeDBi | A6NIR3 |
TreeFami | TF317762 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A6NIR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE
110 120 130 140 150
FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL
160 170 180 190 200
DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH
210 220 230 240 250
ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW
260 270 280 290 300
SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
310 320 330 340 350
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS
360 370 380 390 400
ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK
410 420 430 440 450
KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE
460 470 480 490 500
SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI
510 520 530 540 550
ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG
560 570 580 590 600
QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL
610 620 630 640 650
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV
660 670 680
MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQL4 | J3KQL4_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP5 | 663 | Annotation score: | ||
A0A0D9SFU9 | A0A0D9SFU9_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP5 | 686 | Annotation score: | ||
U3KQ60 | U3KQ60_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP5 | 27 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | C → R in BC127746 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 365 | K → E in BC127746 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 482 | Y → C in BC127746 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073389 Genomic DNA No translation available. AC022400 Genomic DNA No translation available. BC127746 mRNA No translation available. |
CCDSi | CCDS44439.1 |
RefSeqi | NP_001137472.1, NM_001144000.1 |
Genome annotation databases
Ensembli | ENST00000374094; ENSP00000363207; ENSG00000172650 |
GeneIDi | 729092 |
KEGGi | hsa:729092 |
UCSCi | uc009xri.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073389 Genomic DNA No translation available. AC022400 Genomic DNA No translation available. BC127746 mRNA No translation available. |
CCDSi | CCDS44439.1 |
RefSeqi | NP_001137472.1, NM_001144000.1 |
3D structure databases
SMRi | A6NIR3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 609497, 2 interactors |
IntActi | A6NIR3, 2 interactors |
MINTi | A6NIR3 |
STRINGi | 9606.ENSP00000363207 |
PTM databases
iPTMneti | A6NIR3 |
PhosphoSitePlusi | A6NIR3 |
Polymorphism and mutation databases
BioMutai | AGAP5 |
Proteomic databases
jPOSTi | A6NIR3 |
MassIVEi | A6NIR3 |
MaxQBi | A6NIR3 |
PaxDbi | A6NIR3 |
PeptideAtlasi | A6NIR3 |
PRIDEi | A6NIR3 |
ProteomicsDBi | 1279 |
Protocols and materials databases
Antibodypediai | 68077, 43 antibodies |
Genome annotation databases
Ensembli | ENST00000374094; ENSP00000363207; ENSG00000172650 |
GeneIDi | 729092 |
KEGGi | hsa:729092 |
UCSCi | uc009xri.4, human |
Organism-specific databases
CTDi | 729092 |
EuPathDBi | HostDB:ENSG00000172650.12 |
GeneCardsi | AGAP5 |
HGNCi | HGNC:23467, AGAP5 |
HPAi | ENSG00000172650, Low tissue specificity |
neXtProti | NX_A6NIR3 |
PharmGKBi | PA164715123 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0705, Eukaryota |
GeneTreei | ENSGT00940000163475 |
InParanoidi | A6NIR3 |
OrthoDBi | 751525at2759 |
PhylomeDBi | A6NIR3 |
TreeFami | TF317762 |
Enzyme and pathway databases
PathwayCommonsi | A6NIR3 |
Miscellaneous databases
BioGRID-ORCSi | 729092, 299 hits in 807 CRISPR screens |
GenomeRNAii | 729092 |
Pharosi | A6NIR3, Tdark |
PROi | PR:A6NIR3 |
RNActi | A6NIR3, protein |
Gene expression databases
Bgeei | ENSG00000172650, Expressed in body of pancreas and 112 other tissues |
ExpressionAtlasi | A6NIR3, baseline and differential |
Genevisiblei | A6NIR3, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGAP5_HUMAN | |
Accessioni | A6NIR3Primary (citable) accession number: A6NIR3 Secondary accession number(s): A8MSN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM