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UniProtKB - A6NIM6 (S15A5_HUMAN)

Entry version 102 (29 Sep 2021)
Sequence version 2 (29 Apr 2008)
Previous versions | rss
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Protein

Solute carrier family 15 member 5

Gene

SLC15A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton oligopeptide cotransporter.

Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A6NIM6

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.17.3.10, the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 15 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC15A5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33455, SLC15A5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NIM6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188991

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Transmembranei509 – 529HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000188991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164725785

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NIM6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC15A5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322331 – 579Solute carrier family 15 member 5Add BLAST579

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NIM6

PeptideAtlas

More...PeptideAtlasi		A6NIM6

PRoteomics IDEntifications database

More...PRIDEi		A6NIM6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1276

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NIM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188991, Expressed in prefrontal cortex and 19 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188991, Group enriched (adipose tissue, brain, breast, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A6NIM6, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340402

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NIM6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1237, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158916

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009313_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NIM6

Identification of Orthologs from Complete Genome Data

More...OMAi		CLGRTKV

Database of Orthologous Groups

More...OrthoDBi		365203at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NIM6

TreeFam database of animal gene trees

More...TreeFami		TF332925

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036259, MFS_trans_sf
IPR000109, POT_fam

The PANTHER Classification System

More...PANTHERi		PTHR11654, PTHR11654, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00854, PTR2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NIM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE 
        60         70         80         90        100
LCERFTFFEV VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL 
       110        120        130        140        150
TDVYLGRNKL VYICLFLHFL GTALLSVVAF PLEDFYLGTY HAVNNIPKTE 
       160        170        180        190        200
QHRLFYVALL TICLGIGGVR AIVCPLGAFG LQEYGSQKTM SFFNWFYWLM 
       210        220        230        240        250
NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM IYYNLIYQSE 
       260        270        280        290        300
KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV 
       310        320        330        340        350
EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV 
       360        370        380        390        400
MNAISSLPLL ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI 
       410        420        430        440        450
AGFFEIHRKH FPAVEQPLSG KVLTVSSMPC FYLILQYVLL GVAETLVNPA 
       460        470        480        490        500
LSVISYRFVP SNVRGTSMNF LTLFNGFGCF TGALLVKLVY LISDGNWFPN 
       510        520        530        540        550
TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA QNIRGSNLEE 
       560        570 
TLLLHEKSLK FYGSIQEFSS SIDLWETAL
Length:579
Mass (Da):65,263
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i836D5266978C9977
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042979141H → Q. Corresponds to variant dbSNP:rs1799516Ensembl.1
Natural variantiVAR_042980271P → L. Corresponds to variant dbSNP:rs1527014Ensembl.1
Natural variantiVAR_042981494D → E. Corresponds to variant dbSNP:rs1671511Ensembl.1
Natural variantiVAR_042982508E → K. Corresponds to variant dbSNP:rs3946358Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC073574 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001164269.1, NM_001170798.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344941; ENSP00000340402; ENSG00000188991

Database of genes from NCBI RefSeq genomes

More...GeneIDi		729025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:729025

UCSC genome browser

More...UCSCi		uc021qvs.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073574 Genomic DNA No translation available.
RefSeqiNP_001164269.1, NM_001170798.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiA6NIM6, 2 interactors
STRINGi9606.ENSP00000340402

Protein family/group databases

TCDBi2.A.17.3.10, the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

PhosphoSitePlusiA6NIM6

Genetic variation databases

BioMutaiSLC15A5

Proteomic databases

PaxDbiA6NIM6
PeptideAtlasiA6NIM6
PRIDEiA6NIM6
ProteomicsDBi1276

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63873, 11 antibodies

The DNASU plasmid repository

More...DNASUi		729025

Genome annotation databases

EnsembliENST00000344941; ENSP00000340402; ENSG00000188991
GeneIDi729025
KEGGihsa:729025
UCSCiuc021qvs.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		729025

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC15A5
HGNCiHGNC:33455, SLC15A5
HPAiENSG00000188991, Group enriched (adipose tissue, brain, breast, testis)
neXtProtiNX_A6NIM6
OpenTargetsiENSG00000188991
PharmGKBiPA164725785
VEuPathDBiHostDB:ENSG00000188991

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1237, Eukaryota
GeneTreeiENSGT00940000158916
HOGENOMiCLU_009313_6_2_1
InParanoidiA6NIM6
OMAiCLGRTKV
OrthoDBi365203at2759
PhylomeDBiA6NIM6
TreeFamiTF332925

Enzyme and pathway databases

PathwayCommonsiA6NIM6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		729025, 3 hits in 208 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		729025
PharosiA6NIM6, Tdark

Protein Ontology

More...PROi		PR:A6NIM6
RNActiA6NIM6, protein

Gene expression databases

BgeeiENSG00000188991, Expressed in prefrontal cortex and 19 other tissues

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR036259, MFS_trans_sf
IPR000109, POT_fam
PANTHERiPTHR11654, PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854, PTR2, 1 hit
SUPFAMiSSF103473, SSF103473, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS15A5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NIM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 29, 2021
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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