UniProtKB - A6NIM6 (S15A5_HUMAN)
Protein
Solute carrier family 15 member 5
Gene
SLC15A5
Organism
Homo sapiens (Human)
Status
Functioni
Proton oligopeptide cotransporter.Curated
GO - Molecular functioni
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Peptide transport, Protein transport, Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | A6NIM6 |
Protein family/group databases
TCDBi | 2.A.17.3.10, the proton-dependent oligopeptide transporter (pot/ptr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 15 member 5 |
Gene namesi | Name:SLC15A5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33455, SLC15A5 |
neXtProti | NX_A6NIM6 |
VEuPathDBi | HostDB:ENSG00000188991.3 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 221 – 241 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 304 – 324 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 343 – 363 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 386 – 406 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 422 – 442 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 472 – 492 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 509 – 529 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000188991 |
PharmGKBi | PA164725785 |
Miscellaneous databases
Pharosi | A6NIM6, Tdark |
Genetic variation databases
BioMutai | SLC15A5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332233 | 1 – 579 | Solute carrier family 15 member 5Add BLAST | 579 |
Proteomic databases
PaxDbi | A6NIM6 |
PeptideAtlasi | A6NIM6 |
PRIDEi | A6NIM6 |
ProteomicsDBi | 1276 |
PTM databases
PhosphoSitePlusi | A6NIM6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188991, Expressed in prefrontal cortex and 19 other tissues |
Organism-specific databases
HPAi | ENSG00000188991, Group enriched (adipose tissue, brain, breast, testis) |
Interactioni
Binary interactionsi
A6NIM6
With | #Exp. | IntAct |
---|---|---|
SCRIB [Q14160] | 2 | EBI-11792220,EBI-357345 |
Protein-protein interaction databases
IntActi | A6NIM6, 2 interactors |
MINTi | A6NIM6 |
STRINGi | 9606.ENSP00000340402 |
Miscellaneous databases
RNActi | A6NIM6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000158916 |
HOGENOMi | CLU_009313_6_2_1 |
InParanoidi | A6NIM6 |
OMAi | FGIVCNM |
OrthoDBi | 365203at2759 |
PhylomeDBi | A6NIM6 |
TreeFami | TF332925 |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR000109, POT_fam |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
i Sequence
Sequence statusi: Complete.
A6NIM6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE
60 70 80 90 100
LCERFTFFEV VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL
110 120 130 140 150
TDVYLGRNKL VYICLFLHFL GTALLSVVAF PLEDFYLGTY HAVNNIPKTE
160 170 180 190 200
QHRLFYVALL TICLGIGGVR AIVCPLGAFG LQEYGSQKTM SFFNWFYWLM
210 220 230 240 250
NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM IYYNLIYQSE
260 270 280 290 300
KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV
310 320 330 340 350
EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV
360 370 380 390 400
MNAISSLPLL ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI
410 420 430 440 450
AGFFEIHRKH FPAVEQPLSG KVLTVSSMPC FYLILQYVLL GVAETLVNPA
460 470 480 490 500
LSVISYRFVP SNVRGTSMNF LTLFNGFGCF TGALLVKLVY LISDGNWFPN
510 520 530 540 550
TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA QNIRGSNLEE
560 570
TLLLHEKSLK FYGSIQEFSS SIDLWETAL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042979 | 141 | H → Q. Corresponds to variant dbSNP:rs1799516Ensembl. | 1 | |
Natural variantiVAR_042980 | 271 | P → L. Corresponds to variant dbSNP:rs1527014Ensembl. | 1 | |
Natural variantiVAR_042981 | 494 | D → E. Corresponds to variant dbSNP:rs1671511Ensembl. | 1 | |
Natural variantiVAR_042982 | 508 | E → K. Corresponds to variant dbSNP:rs3946358Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073574 Genomic DNA No translation available. |
RefSeqi | NP_001164269.1, NM_001170798.1 |
Genome annotation databases
Ensembli | ENST00000344941; ENSP00000340402; ENSG00000188991 |
GeneIDi | 729025 |
KEGGi | hsa:729025 |
UCSCi | uc021qvs.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073574 Genomic DNA No translation available. |
RefSeqi | NP_001164269.1, NM_001170798.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A6NIM6, 2 interactors |
MINTi | A6NIM6 |
STRINGi | 9606.ENSP00000340402 |
Protein family/group databases
TCDBi | 2.A.17.3.10, the proton-dependent oligopeptide transporter (pot/ptr) family |
PTM databases
PhosphoSitePlusi | A6NIM6 |
Genetic variation databases
BioMutai | SLC15A5 |
Proteomic databases
PaxDbi | A6NIM6 |
PeptideAtlasi | A6NIM6 |
PRIDEi | A6NIM6 |
ProteomicsDBi | 1276 |
Protocols and materials databases
Antibodypediai | 63873, 11 antibodies |
Genome annotation databases
Ensembli | ENST00000344941; ENSP00000340402; ENSG00000188991 |
GeneIDi | 729025 |
KEGGi | hsa:729025 |
UCSCi | uc021qvs.1, human |
Organism-specific databases
CTDi | 729025 |
GeneCardsi | SLC15A5 |
HGNCi | HGNC:33455, SLC15A5 |
HPAi | ENSG00000188991, Group enriched (adipose tissue, brain, breast, testis) |
neXtProti | NX_A6NIM6 |
OpenTargetsi | ENSG00000188991 |
PharmGKBi | PA164725785 |
VEuPathDBi | HostDB:ENSG00000188991.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000158916 |
HOGENOMi | CLU_009313_6_2_1 |
InParanoidi | A6NIM6 |
OMAi | FGIVCNM |
OrthoDBi | 365203at2759 |
PhylomeDBi | A6NIM6 |
TreeFami | TF332925 |
Enzyme and pathway databases
PathwayCommonsi | A6NIM6 |
Miscellaneous databases
BioGRID-ORCSi | 729025, 2 hits in 103 CRISPR screens |
GenomeRNAii | 729025 |
Pharosi | A6NIM6, Tdark |
PROi | PR:A6NIM6 |
RNActi | A6NIM6, protein |
Gene expression databases
Bgeei | ENSG00000188991, Expressed in prefrontal cortex and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR000109, POT_fam |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S15A5_HUMAN | |
Accessioni | A6NIM6Primary (citable) accession number: A6NIM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | April 29, 2008 | |
Last modified: | February 10, 2021 | |
This is version 99 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants