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Protein

Olfactory receptor 6C70

Gene

OR6C70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C70
Gene namesi
Name:OR6C70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000184954.4
HGNCiHGNC:31299 OR6C70
neXtProtiNX_A6NIJ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 63CytoplasmicSequence analysisAdd BLAST20
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 95ExtracellularSequence analysisAdd BLAST11
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 141CytoplasmicSequence analysisAdd BLAST25
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 194ExtracellularSequence analysisAdd BLAST32
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 237CytoplasmicSequence analysisAdd BLAST22
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 272ExtracellularSequence analysisAdd BLAST14
Transmembranei273 – 290Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915898

Polymorphism and mutation databases

BioMutaiOR6C70

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094931 – 312Olfactory receptor 6C70Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NIJ9
PRIDEiA6NIJ9
ProteomicsDBi1272

PTM databases

iPTMnetiA6NIJ9
PhosphoSitePlusiA6NIJ9

Expressioni

Gene expression databases

BgeeiENSG00000184954 Expressed in 1 organ(s), highest expression level in heart left ventricle
CleanExiHS_OR6C70

Interactioni

Protein-protein interaction databases

BioGridi133517, 1 interactor
STRINGi9606.ENSP00000329153

Structurei

3D structure databases

ProteinModelPortaliA6NIJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJ6 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NIJ9
KOiK04257
OMAiPRFLITT
OrthoDBiEOG091G0F9F
PhylomeDBiA6NIJ9
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NIJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNHTRQIEF ILLGLTDNSQ LQIVIFLFLL LNCVLSMIGN FTIIALILLD
60 70 80 90 100
SQLKTPMYFF LRNFSFLEIS FTTACIPRFL ITIVTREKTI SCNGCISQLF
110 120 130 140 150
FYIFLGVTEF FLLAALSYDR YVAICKPLRY MSIMSNKVCY QLVFSSWVTG
160 170 180 190 200
FLIIFTPLIL GLNLDFCASN IIDHFICDIS LILQLSCSDT HLLELIAFLL
210 220 230 240 250
AVMTLIVTLF LVILSYSYII KTILKFPSAQ QKKKAFSTCS SHMIVVSITY
260 270 280 290 300
GSCMFIYIKP SANERVALSK GVTVLNTSVA PLLNPFIYTL RNQQVKQAFK
310
AVFRKIFSAS DK
Length:312
Mass (Da):35,468
Last modified:July 24, 2007 - v1
Checksum:i91E1E0CD33990336
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036971181L → P. Corresponds to variant dbSNP:rs10747756Ensembl.1
Natural variantiVAR_062050233K → N. Corresponds to variant dbSNP:rs60683621Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122685 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96813.1
CCDSiCCDS31825.1
RefSeqiNP_001005499.1, NM_001005499.1
UniGeneiHs.632718

Genome annotation databases

EnsembliENST00000327335; ENSP00000329153; ENSG00000184954
GeneIDi390327
KEGGihsa:390327
UCSCiuc010spn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122685 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96813.1
CCDSiCCDS31825.1
RefSeqiNP_001005499.1, NM_001005499.1
UniGeneiHs.632718

3D structure databases

ProteinModelPortaliA6NIJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133517, 1 interactor
STRINGi9606.ENSP00000329153

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NIJ9
PhosphoSitePlusiA6NIJ9

Polymorphism and mutation databases

BioMutaiOR6C70

Proteomic databases

PaxDbiA6NIJ9
PRIDEiA6NIJ9
ProteomicsDBi1272

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327335; ENSP00000329153; ENSG00000184954
GeneIDi390327
KEGGihsa:390327
UCSCiuc010spn.2 human

Organism-specific databases

CTDi390327
EuPathDBiHostDB:ENSG00000184954.4
GeneCardsiOR6C70
HGNCiHGNC:31299 OR6C70
neXtProtiNX_A6NIJ9
PharmGKBiPA134915898
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJ6 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NIJ9
KOiK04257
OMAiPRFLITT
OrthoDBiEOG091G0F9F
PhylomeDBiA6NIJ9
TreeFamiTF336833

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii390327
PROiPR:A6NIJ9

Gene expression databases

BgeeiENSG00000184954 Expressed in 1 organ(s), highest expression level in heart left ventricle
CleanExiHS_OR6C70

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO6C70_HUMAN
AccessioniPrimary (citable) accession number: A6NIJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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